Neurodevelopmental outcome related to cerebral risk factors in children after neonatal arterial switch operation

Hövels-Gürich, Hedwig H.; Seghaye, Marie-Christine; Sigler, Matthias; Kotlarek, F.; Bartl, A; Neuser, Jürgen; Minkenberg, Ralf; Messmer, Bruno J.; Bernuth, G. von

doi:10.1016/s0003-4975(00)02515-7

Cited by 54 publications

(33 citation statements)

References 22 publications

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“…Compared to children with VSD and healthy school children, the group with congenital heart defects showed no differences on the Rey-Osterrieth Complex Figure Test and the Selective Reminding test (Oates et al, 1995 a). Up to 96.7% of the children who had an arterial switch operation for transposition of the great arteries performed normally on learning and memory tasks (Hövels-Gürich et al, 2001). The single ventricle group, however, displayed significantly lower scores for design memory at the age of 5 years .…”

Section: Memorymentioning

confidence: 85%

Neurocognitive Consequences of Surgically Corrected Congenital Heart Defects: A Review

et al. 2006

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With advances in surgical procedures, neuropsychological assessment after congenital heart defects and pre, peri- and/or postoperative predictors of adverse outcome has become an important focus in research. We aim to summarize neuropsychological sequelae associated with different types of congenital heart defects, critically review the methodology used in more than 20 empirical studies that were retrieved from biomedical electronic search engines, and identify possible directions for future research. Despite the lack of adequate control groups and long-term studies, there seem to be some cognitive deficits. The largest group of children with isolated congenital heart defects present with normal intellectual capacities. However, they tend to show language deficits and motor dysfunction. Although performances on memory tasks are good, unambiguous conclusions concerning their attentional and executive functioning are still lacking. Serious behavioral problems are not an issue. In addition to a detailed description of the (neuro) psychological consequences of pediatric cardiac surgery, an overview of the predictors of the cognitive defects is provided.

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Section: Memorymentioning

confidence: 85%

Neurocognitive Consequences of Surgically Corrected Congenital Heart Defects: A Review

et al. 2006

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“…The inflammatory reaction induced by CPB seems to be delayed rather than diminished by hypothermia [6]. Finally, when hypothermic bypass is associated with a circulatory arrest, long-term follow up has shown impaired neuro-developmental outcome [7]. Therefore, normothermic CPB, already commonly used in adult cardiac surgery, has been progressively extended in our paediatric practice [8,9].…”

Section: Introductionmentioning

confidence: 99%

Normothermic cardiopulmonary bypass and myocardial cardioplegic protection for neonatal arterial switch operation

Pouard

Mauriat

et al. 2006

European Journal of Cardio-Thoracic Surgery

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“…Attention has been directed to neurological dysfunction and developmental sequelae accompanying neonatal cardiac surgery with its support techniquescontinuous low flow cardiopulmonary bypass, either isolated or combined with cardiocirculatory arrest in deep hypothermia. [1][2][3][4][5] Long term behavioural outcome and quality of life have not been addressed so far in older children after uniform corrective cardiac surgery as neonates. Children with TGA are a group without any known prevalent risk of genetic abnormality with respect to morbidity of the central nervous system.…”

mentioning

confidence: 99%

Long term behavioural outcome after neonatal arterial switch operation for transposition of the great arteries

Hövels-Gürich

Konrad

Wiesner

et al. 2002

Archives of Disease in Childhood

141

128

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Aims: To evaluate behavioural outcome and quality of life in children aged 8-14 years after neonatal arterial switch operation for transposition of the great arteries. Methods: Sixty children operated as neonates with combined deep hypothermic circulatory arrest and low flow cardiopulmonary bypass were evaluated at age 7.9-14.3 years by the Child Behaviour Checklist (CBCL) and the Inventory for the Assessment of the Quality of Life in Children and Adolescents (IQCL). Results: Parent reported behavioural outcome on all CBCL problem and competence scores was worse, whereas quality of life on self reported IQCL scores was not reduced compared to the normal population. On multivariate analysis, severe preoperative hypoxia was related to parent reported social problems; peri-and postoperative cardiocirculatory insufficiency was associated with internalising, externalising, attention, and total behavioural problems. Reduced expressive language was associated with total behavioural problems, and poor academic achievement was related to parent reported deficits in school performance. Impaired neurological status and reduced endurance capacity both predicted self reported stress by illness. Conclusions: The neonatal arterial switch operation with combined circulatory arrest and low flow bypass is associated with parent reported long term behavioural impairment, but not with self reported general reduction in quality of life. This discrepancy may be a result of different perception of illness. In our experience, increased risk of long term psychosocial maladjustment after neonatal corrective cardiac surgery is related to the presence of neurological impairment and reduced endurance capacity.

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Neurodevelopmental outcome related to cerebral risk factors in children after neonatal arterial switch operation

Cited by 54 publications

References 22 publications

Neurocognitive Consequences of Surgically Corrected Congenital Heart Defects: A Review

Neurocognitive Consequences of Surgically Corrected Congenital Heart Defects: A Review

Normothermic cardiopulmonary bypass and myocardial cardioplegic protection for neonatal arterial switch operation

Long term behavioural outcome after neonatal arterial switch operation for transposition of the great arteries

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