Neurodevelopmental outcomes after neonatal surgery

Lo, E.; Kalish, Brian T.

doi:10.1007/s00383-022-05285-x

Cited by 4 publications

(2 citation statements)

References 66 publications

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“…As noted by Lo and Kalish, inflammation during the surgical intervention also might affect brain development, which could be negatively influenced by the cumulative action of systemic cytokines. At the same time, they also claim that uncontrolled post-operative pain might have detrimental effects on neurodevelopment, as the persistent activation of nociceptors can be dangerous [ 52 ]. Therefore, inadequate post-operative analgesia and anti-inflammatory management can also be counted as confounding factors.…”

Section: Discussionmentioning

confidence: 99%

Multiple General Anesthesia in Children: A Systematic Review of Its Effect on Neurodevelopment

Colletti

Bartolomeo

Negrello

et al. 2023

JPM

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The effect of multiple general anesthesia (mGA) procedures administered in early life is a critical theme and has led the Food and Drug Administration (FDA) to issue an alert. This systematic review seeks to explore the potential effects on neurodevelopment of mGA on patients under 4 years. The Medline, Embase and Web of Science databases were searched for publications up to 31 March 2021. The databases were searched for publications regarding “children multiple general anesthesia OR pediatric multiple general anesthesia”. Case reports, animal studies and expert opinions were excluded. Systematic reviews were not included, but they were screened to identify any possible additional information. A total of 3156 studies were identified. After removing the duplicates, screening the remaining records and analyzing the systematic reviews’ bibliography, 10 studies were considered suitable for inclusion. Comprehensively, a total cohort of 264.759 unexposed children and 11.027 exposed children were assessed for neurodevelopmental outcomes. Only one paper did not find any statistically significant difference between exposed and unexposed children in terms of neurodevelopmental alterations. Controlled studies on mGA administered before 4 years of age support that there might be a greater risk of neurodevelopmental delay in children receiving mGA, warranting the need for careful risk/benefit considerations.

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Section: Discussionmentioning

confidence: 99%

Multiple General Anesthesia in Children: A Systematic Review of Its Effect on Neurodevelopment

Colletti

Bartolomeo

Negrello

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

“…Pain has a well-documented impact on neurodevelopmental outcomes in children born before term ( 2 , 3 ). A growing body of evidence informs the risks associated with major surgery (and consequent exposure to pain and anesthesia) in term infants ( 4 ). Consequently, clinicians prioritize the provision of analgesia and sedation in vulnerable infants ( 5 ).…”

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confidence: 99%