Neurodevelopmental Outcomes in Early Childhood

Duncan, Andrea F.; Matthews, Melissa A.

doi:10.1016/j.clp.2018.05.001

Cited by 71 publications

(57 citation statements)

References 79 publications

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“…It is important to note that logistic regression models seemed to show a trend of poorer language skills in children with low socioeconomic status, regardless the type of feeding received. There are different factors, such as genetic background, sex, intrauterine growth restriction, nutrition, maternal education, and socioeconomic status, among others, that have an important role during brain development [39]. Others researchers have reported that children born in families with lower socioeconomic status showed slower language development [40,41].…”

Section: Discussionmentioning

confidence: 99%

Influence of a Functional Nutrients-Enriched Infant Formula on Language Development in Healthy Children at Four Years Old

et al. 2020

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Nutrition during early life is essential for brain development and establishes the basis for cognitive and language skills development. It is well established that breastfeeding, compared to formula feeding, has been traditionally associated with increased neurodevelopmental scores up to early adulthood. We analyzed the long-term effects of a new infant formula enriched with bioactive compounds on healthy children’s language development at four years old. In a randomized double-blind COGNIS study, 122 children attended the follow-up call at four years. From them, 89 children were fed a standard infant formula (SF, n = 46) or an experimental infant formula enriched with functional nutrients (EF, n = 43) during their first 18 months of life. As a reference group, 33 exclusively breastfed (BF) were included. Language development was assessed using the Oral Language Task of Navarra-Revised (PLON-R). ANCOVA, chi-square test, and logistic regression models were performed. EF children seemed to show higher scores in use of language and oral spontaneous expression than SF children, and both SF and EF groups did not differ from the BF group. Moreover, it seems that SF children were more frequently categorized into “need to improve and delayed” in the use of language than EF children, and might more frequently present “need to improve and delayed” in the PLON-R total score than BF children. Finally, the results suggest that SF children presented a higher risk of suffering language development than BF children. Secondary analysis also showed a slight trend between low socioeconomic status and poorer language skills. The functional compound-enriched infant formula seems to be associated with beneficial long-term effects in the development of child’s language at four years old in a similar way to breastfed infants.

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Section: Discussionmentioning

confidence: 99%

Influence of a Functional Nutrients-Enriched Infant Formula on Language Development in Healthy Children at Four Years Old

et al. 2020

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“…It has been found that the neonatal brain injury can result not only in motor dysfunction, but can also lead to several other neurological deficits including visual and auditory impairments and behavioral abnormalities (2, 5, 44). In recent years, ERPs have been used to help determine cognitive and neurodevelopmental difficulties in children.…”

Section: Discussionmentioning

confidence: 99%

Impact of Brain Injury on Processing of Emotional Prosodies in Neonates

et al. 2019

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Being able to appropriately process different emotional prosodies is an important cognitive ability normally present at birth. In this study, we used event-related potential (ERP) to assess whether brain injury impacts the ability to process different emotional prosodies (happy, fear, and neutral) in neonates; whether the ERP measure has potential value for the evaluation of neurodevelopmental outcome in later childhood. A total of 42 full-term neonates were recruited from the neonatology department of Peking University First Hospital from June 2014 to January 2015. They were assigned to the brain injury group ( n = 20) or control group ( n = 22) according to their clinical manifestations, physical examinations, cranial images and routine EEG outcomes. Using an oddball paradigm, ERP data were recorded while subjects listened to happy (20%, deviation stimulus), fearful (20%, deviation stimulus) and neutral (80%, standard stimulus) prosodies to evaluate the potential prognostic value of ERP indexes for neurodevelopment at 30 months of age. Results showed that while the mismatch responses (MMRs) at the frontal lobe were larger for fearful than happy prosody in control neonates, this difference was not observed in neonates with brain injuries. This finding suggests that perinatal brain injury may influence the cognitive ability to process different emotional prosodies in neonatal brain; this deficit could be reflected by decreased MMR amplitudes in response to fearful prosody. Moreover, the decreased MMRs at the frontal lobe was associated with impaired neurodevelopment at 30 months old.

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“…Increased admissions for prematurity (although not reaching statistical significance) with comparatively lower top‐up transfusion rates ( P = 0.016) for fetuses born at the study centre compared to other centres, suggest we are aggressive in our approach to early delivery. We could therefore potentially afford to delay delivery and subsequently reduce the risks associated with prematurity, namely long‐term neurodevelopmental risks 24 . Such an approach needs to be balanced against the risks of increased neonatal intervention (if delivery is delayed without giving an extra antenatal transfusion) or further IUT (if this is used to delay delivery until 37 + weeks).…”

Section: Discussionmentioning

confidence: 99%

Short‐term outcomes following intrauterine transfusions for fetal anaemia: A retrospective cohort study

Urutherakumar

Welsh

Henry

2020

Aust NZ J Obst Gynaeco

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Background: Intrauterine transfusion (IUT) is the accepted standard for management of severe fetal anaemia. However, fetal transfusion may be associated with procedural complications such as fetal demise. There is a paucity of recent data on outcomes for severe fetal anaemia in Australia as compared with published outcomes from large international centres. Aims: To review the indications for and the procedural, obstetric and neonatal outcomes following intrauterine transfusion for fetal anaemia conducted at the New South Wales Fetal Therapy Centre (NSW FTC). Materials and Methods: Retrospective cohort study conducted between 2005 and 2017 of the outcomes of 85 IUT procedures (39 pregnancies). Data collected included maternal demographics, procedural and obstetric details and short-term neonatal outcomes. Results: Complete outcome data were available for 36/39 pregnancies. Red cell antibodies were the main indication for fetal transfusion (79%, predominantly D, Kell and other Rhesus antibodies) with parvovirus accounting for 8% of procedures. IUT was associated with a pregnancy loss rate of 1.2%/procedure, amounting to 2.6%/ pregnancy. Fetal losses were limited to those complicated by hydrops prior to IUT (3/10 hydrops vs 0/26 non-hydropic; P = 0.003). Conclusions: Procedural outcomes at NSW FTC compare favourably with international centres (1.1-8.7% procedural loss rate). However, this comparison is limited, as no procedures were performed during the last 24 months of the study. Given this, a nationwide audit is recommended to help guide appropriate centralisation of procedures and thereby maximise clinician experience and outcome.

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Neurodevelopmental Outcomes in Early Childhood

Cited by 71 publications

References 79 publications

Influence of a Functional Nutrients-Enriched Infant Formula on Language Development in Healthy Children at Four Years Old

Influence of a Functional Nutrients-Enriched Infant Formula on Language Development in Healthy Children at Four Years Old

Impact of Brain Injury on Processing of Emotional Prosodies in Neonates

Short‐term outcomes following intrauterine transfusions for fetal anaemia: A retrospective cohort study

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