Neurodevelopmental outcomes in mild and moderate isolated ventriculomegaly originating
            <i>in utero</i>

Sun, Guozhu; Jing, Baihua; Zhou, Faliang; Liu, Hongyan; Liu, Lili; Chen, Junya; Hou, Xinlin

doi:10.1080/14767058.2021.1919869

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…An increased risk of neurodevelopmental delay is positively associated with a higher degree of dilatation ( Weichert et al, 2010 ). A prospective cohort study assessed the neurodevelopmental outcomes of 94 fetuses with VM, the rate of neurodevelopmental impairment of fetuses with mild and moderate VM increased from 8.3 to 17.6% ( Sun et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly

et al. 2022

Front. Hum. Neurosci.

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BackgroundFetal ventriculomegaly (VM) is one of the most common abnormalities of the central nervous system (CNS), which can be significantly identified by brain anomalies prenatally by magnetic resonance imaging (MRI). Aberrant white blood cells (WBCs) levels indicate that the maternal is suffering from the infection. Previous studies have confirmed that prenatal infection can affect fetal brain structure, but there is no research revealed the association between maternal blood parameters with fetal VM until now.MethodsWe measured the width of the lateral ventricle of 142 fetuses, which were divided into the fetal VM group (n = 70) and the normal lateral ventricle group (n = 72). We compared maternal blood cell levels between the two groups and investigate potential biomarkers of fetal VM.ResultHigh levels of maternal WBC and neutrophil (NE#) levels were observed in fetuses with VM (p < 0.001), while lymphocyte percentage, monocytes (MO#), neutrophil/lymphocyte ratio (NLR), and platelet were also increased in the fetal VM group (p = 0.033, 0.027, 0.034, and 0.025, respectively). receiver–operator curve (ROC) analysis suggested that WBC and NE# counts might be useful to distinguish fetuses with enlarged lateral ventricles (AUC = 0.688, 0.678, respectively).ConclusionThe current study emphasizes the importance of maternal infection for fetal brain growth, which could provide important information for prenatal diagnosis of CNS anomalies. Future research needs longitudinal analysis and exploration of the influence of maternal blood inflammatory marker levels on fetal brain development.

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Section: Introductionmentioning

confidence: 99%

Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly

et al. 2022

Front. Hum. Neurosci.

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Prenatal detection of mild fetal ventriculomegaly – a systematic review of the modern literature

Sapantzoglou,

Asimakopoulos,

Fasoulakis

et al. 2024

Ultraschall Med

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Introduction While mild fetal ventriculomegaly is frequently observed as an incidental and benign finding, it is also known to be linked with structural, genetic, and neurodevelopmental abnormalities. The objective of this study was to conduct a systematic review of the existing literature in order to evaluate the association between apparently isolated fetal mild ventriculomegaly with the presence of additional structural defects detected by fetal brain MRI, chromosomal or other genetic anomalies, and neurodevelopmental delay. Methods This systematic review was designed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Modern literature was searched from January 1, 2011, to July 31, 2023. Results 23 studies were included, comprising a total of 2590 patients. Nine studies assessed the association between fetal mild ventriculomegaly and neurodevelopmental impairment, including 536 cases, with normal neurodevelopmental outcomes ranging from 64% to 96.5%. Ten studies evaluated the additive value of fetal MRI, including 1266 fetuses, with the detection rate of additional brain defects that eventually altered the clinical management ranging from 0% to 19.5%. Seven studies investigated the association of mild ventriculomegaly with the presence of underlying chromosomal or genetic conditions, including 747 cases, with the rate ranging from 1.1% to 15.4%. Conclusion The prevalence of aneuploidy and genetic abnormalities in ventriculomegaly, especially in isolated cases, is reported to be quite low and the incidence of neurodevelopmental delay appears to be similar to that of the general population in cases that are apparently and truly isolated.

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Comprehensive assessment of fetal ventriculomegaly in a tertiary referral center

Guo,

He,

Lin

et al. 2023

Preprint

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Fetal ventriculomegaly (VM) is a condition in which the cerebral ventricular diameter measures ≥10 mm during the second and third trimesters of pregnancy as detected by prenatal ultrasound scan. The prognosis of fetal VM vary widely. We conducted the retrospective study aims to systematically evaluate the genetic disorders, congenital cytomegalovirus (CMV) infection, and pregnancy outcomes of ventriculomegaly (VM) in fetuses. Our results demonstrated that non-isolated ventriculomegaly increased linearly with the atrial width. 8.68% VM fetus had chromosomal aberrations through conventional karyotyping, chromosomal microarray analysis revealed additional 4.1% of copy number variants with clinical significance. 2.5% VM fetus were confirmed as CMV intrauterine infection. Additional abnormalities, especially CNS abnormalities often led to TOP and unfavorable outcomes. Severe VM, intrauterine progression or stability are risk factors for unfavorable outcomes. At least 61.9% of the adverse outcomes have the sustained intracranial imaging anomalies. Thus, chromosomal disorders and congenital CMV infection are common etiologies of VM. Consistent prenatal and postnatal imaging scans should be provided for fetuses with VM to ensure better pregnancy management.

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Neurodevelopmental outcomes in mild and moderate isolated ventriculomegaly originating in utero

Cited by 3 publications

References 31 publications

Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly

Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly

Prenatal detection of mild fetal ventriculomegaly – a systematic review of the modern literature

Comprehensive assessment of fetal ventriculomegaly in a tertiary referral center

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