Neurodevelopmental Outcomes in Pediatric Heart Transplant Recipients

Uzark, Karen; Spicer, Robert L.; Beebe, Dean W.

doi:10.1016/j.healun.2009.05.002

Cited by 40 publications

(31 citation statements)

References 13 publications

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“…20 School and cognitive problems observed in our study have been reported by others, including increased risk of developmental or cognitive deficits and increased absence from school. [21][22][23] Interestingly, the observed trouble solving math problems in our study is also consistent with objective measurement of arithmetic scores in heart transplant recipients reported by others. 2,17 Identification of developmental or cognitive deficits after transplant is important to design interventions to optimize school functioning.…”

Section: Discussionsupporting

confidence: 92%

Quality of life in pediatric heart transplant recipients: A comparison with children with and without heart disease

Uzark

Griffin

Rodriguez

et al. 2012

The Journal of Heart and Lung Transplantation

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Section: Discussionsupporting

confidence: 92%

Quality of life in pediatric heart transplant recipients: A comparison with children with and without heart disease

Uzark

Griffin

Rodriguez

et al. 2012

The Journal of Heart and Lung Transplantation

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“…[101][102][103][104][105][106][107][108][109][110][111][112][113] Neurological events (eg, thromboembolism, hemorrhage) may occur when patients are placed on extracorporeal membrane oxygenation or ventricular assist devices with or without subsequent heart transplantation. 102,104,107,109 Developmental delays and disabilities after heart transplantation include delays in motor development, speech/language acquisition, and abstract reasoning/goaldirected behaviors 110 and impairments in IQ, 111 expressive language, 111 visual-motor skills, 111 fine motor skills, 111 psychosocial functioning, 112 and psychomotor scores. 113 …”

Section: Mechanical Support or Heart Transplantationmentioning

confidence: 99%

“…156 In 2009, the Centers for Disease Control and Prevention reported an estimated prevalence of autism spectrum disorders of 9 per 1000 or 1 per 110 in children 8 years of age. 158 A number of recent studies have suggested that children with CHD may be at increased risk for communication impairment, 54,111 decreased social competence, 159 and autism spectrum disorders 160 -162 compared with the estimated prevalence for the general population. Bellinger 159 studied children with TGA and noted social impairments, including the inability to "read" other people ("theory of mind" domain).…”

Section: Autism Spectrum Disordersmentioning

confidence: 99%

Neurodevelopmental Outcomes in Children With Congenital Heart Disease: Evaluation and Management

Marino¹,

Lipkin²,

Newburger³

et al. 2012

Circulation

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1,329

1,156

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Background— The goal of this statement was to review the available literature on surveillance, screening, evaluation, and management strategies and put forward a scientific statement that would comprehensively review the literature and create recommendations to optimize neurodevelopmental outcome in the pediatric congenital heart disease (CHD) population. Methods and Results— A writing group appointed by the American Heart Association and American Academy of Pediatrics reviewed the available literature addressing developmental disorder and disability and developmental delay in the CHD population, with specific attention given to surveillance, screening, evaluation, and management strategies. MEDLINE and Google Scholar database searches from 1966 to 2011 were performed for English-language articles cross-referencing CHD with pertinent search terms. The reference lists of identified articles were also searched. The American College of Cardiology/American Heart Association classification of recommendations and levels of evidence for practice guidelines were used. A management algorithm was devised that stratified children with CHD on the basis of established risk factors. For those deemed to be at high risk for developmental disorder or disabilities or for developmental delay, formal, periodic developmental and medical evaluations are recommended. A CHD algorithm for surveillance, screening, evaluation, reevaluation, and management of developmental disorder or disability has been constructed to serve as a supplement to the 2006 American Academy of Pediatrics statement on developmental surveillance and screening. The proposed algorithm is designed to be carried out within the context of the medical home. This scientific statement is meant for medical providers within the medical home who care for patients with CHD. Conclusions— Children with CHD are at increased risk of developmental disorder or disabilities or developmental delay. Periodic developmental surveillance, screening, evaluation, and reevaluation throughout childhood may enhance identification of significant deficits, allowing for appropriate therapies and education to enhance later academic, behavioral, psychosocial, and adaptive functioning.

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“…9,10 Specific neurocognitive deficits in school-aged children with HTx have emerged in the verbal domains of expressive and receptive language, 3,6,7 spelling, 1,2,4,11 and reading skills, 4,11 and also in visuomotor abilities, 3 nonverbal reasoning, 1 arithmetic, 3,4,11 short-term memory, 1 and speed of information processing. 1 A recent study 12 identified an increased risk for deficits in expressive language among infants and in visual-motor and fine-motor integration in children aged 1 to 10 years compared with test norms.…”

mentioning

confidence: 99%

“…The error bars denote Ϯ 1 standard errors of measurement. The horizontal line indicates the mean 10 (standard score, 3; range,[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] in the normal population ( † p Ͻ 0.10, * p Ͻ 0.05, ** p Ͻ 0.01).…”

mentioning

confidence: 99%