Neurodevelopmental outcomes of children with congenital heart disease: A review

Howell, Heather; Zaccario, Michele; Kazmi, Sadaf H.; Desai, Patricia; Sklamberg, Felice E.; Mally, Pradeep

doi:10.1016/j.cppeds.2019.100685

Cited by 58 publications

(56 citation statements)

References 158 publications

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“…We also observed clusters of significant reductions in the frontal lobes. The frontal lobes are associated with many higher cognitive functions, including attention, executive function, impulse control, language, and memory 53 , functions which may be impaired in children with CHD 54 – 56 .…”

Section: Discussionmentioning

confidence: 99%

Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Bonthrone

Kelly

et al. 2020

Sci Rep

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Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO2) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO2 and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO2. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.

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Section: Discussionmentioning

confidence: 99%

Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Bonthrone

Kelly

et al. 2020

Sci Rep

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“…The cause of these neurodevelopmental delays in this population is hypothesized to be multifactorial and characterized by complex pathways over time (9). Brain dysmaturation, frequently observed in infants with CHD, is suggested as a risk factor, making them neurologically vulnerable to a myriad of stressors early in life, particularly during hospitalization due to openheart surgery (10). A recent review on the psychosocial development of infants with CHD shows that they are also at risk for emotional, behavioral, and social difficulties (11).…”

Section: Introductionmentioning

confidence: 99%

Family-Centered Care at Pediatric Cardiac Intensive Care Units in Germany and the Relationship With Parent and Infant Well-Being: A Study Protocol

et al. 2021

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Rationale and Aim: Infants with Congenital Heart Disease (CHD) are at risk for neurodevelopmental delays, emotional, social and behavioral difficulties. Hospitalization early in life and associated stressors may contribute to these challenges. Family-centered Care (FCC) is a health care approach that is respectful of and responsive to the needs and values of a family and has shown to be effective in improving health outcomes of premature infants, as well as the mental well-being of their parents. However, there is limited empirical data available on FCC practices in pediatric cardiology and associations with parent and infant outcomes.Methods and Analysis: In this cross-sectional study, we will explore FCC practices at two pediatric cardiac intensive care units in Germany, assess parent satisfaction with FCC, and investigate associations with parental mental well-being and parenting stress, as well as infant physical and mental well-being. We will collect data of 280 infants with CHD and their families. Data will be analyzed using multivariate statistics and multilevel modeling.Implications and Dissemination: The study protocol was approved by the medical ethics committees of both partner sites and registered with the German registry for clinical trials (NR DRKS00023964). This study serves as a first step to investigate FCC practices in a pediatric cardiology setting, providing insight into the relationship between FCC and parent and infant outcomes in a population of infants with CHD. Results will be disseminated in peer-reviewed journals.

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“…Congenital heart defects comprise some of the most common, serious, and clinically important groups/types of birth defects [ 1 , 2 , 3 ]. These defects consist of a heterogenous group of structural heart malformations (i.e., conotruncal heart defects that affect the cardiac outflow tract) that are thought to have at least some shared genetic basis [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…1 Data only shown for genes with p-values < 0.05 in both individual cohorts (deleted, non-deleted) and with a lower p-value in the combined (deleted + non-deleted) cohort than in both individual cohorts 2. Three meta-analyses: cohort with 22q.11.2 deletion syndrome; cohort without 22q.11.2 deletion syndrome; all cohorts combined.…”

mentioning

confidence: 99%

Genome-Wide Association Studies of Conotruncal Heart Defects with Normally Related Great Vessels in the United States

Oluwafemi

Musfee

Mitchell

et al. 2021

Genes

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Conotruncal defects with normally related great vessels (CTD-NRGVs) occur in both patients with and without 22q11.2 deletion syndrome (22q11.2DS), but it is unclear to what extent the genetically complex etiologies of these heart defects may overlap across these two groups, potentially involving variation within and/or outside of the 22q11.2 region. To explore this potential overlap, we conducted genome-wide SNP-level, gene-level, and gene set analyses using common variants, separately in each of five cohorts, including two with 22q11.2DS (N = 1472 total cases) and three without 22q11.2DS (N = 935 total cases). Results from the SNP-level analyses were combined in meta-analyses, and summary statistics from these analyses were also used in gene and gene set analyses. Across all these analyses, no association was significant after correction for multiple comparisons. However, several SNPs, genes, and gene sets with suggestive evidence of association were identified. For common inherited variants, we did not identify strong evidence for shared genomic mechanisms for CTD-NRGVs across individuals with and without 22q11.2 deletions. Nevertheless, several of our top gene-level and gene set results have been linked to cardiogenesis and may represent candidates for future work.

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Neurodevelopmental outcomes of children with congenital heart disease: A review

Cited by 58 publications

References 158 publications

Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Family-Centered Care at Pediatric Cardiac Intensive Care Units in Germany and the Relationship With Parent and Infant Well-Being: A Study Protocol

Genome-Wide Association Studies of Conotruncal Heart Defects with Normally Related Great Vessels in the United States

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