“Neuroendocrine adenoma of the middle ear with the history of otitis media and carcinoma of the cheek: a case report”

Abstract

BackgroundNeuroendocrine adenomas of the middle ear are rare benign tumors deriving from middle ear mucosal cell with both neuroendocrine and epithelial properties. Approximately one hundred cases have been reported in the literature. Here we report a patient with neuroendocrine adenoma of the middle ear with the history of otitis media; the patient earlier had received radiotherapy for the treatment of basal cell carcinoma.Case presentationA 49- year- old Saudi man presented with a progressive hearing loss and fullness in the left ear with the history of otitis media for which he had undergone myringotomy and ventilating tubes insertion. Earlier at the age of 45 years this patient was given radiotherapy for the treatment of basal cell carcinoma in his cheek. The otoscopy showed a protruded external ear mass obscuring the tympanic membrane. Microscopy and histological examination suggested an endocrine adenoma of the middle ear. The computerized tomography scan of the temporal bone showed an extensive soft tissue mass without any osteolysis. Histological and immunohistochemical examination following surgical excision confirmed the diagnosis of neuroendocrine adenoma of the middle ear.ConclusionA rare case of neuroendocrine adenoma of the middle ear with earlier history of otitis media and carcinoma of the cheek is presented here. Surgical excision of mass resulted in uneventful recovery. Although the etiologic factors leading to the disease is far from clear, the role of radiotherapy given for the treatment of basal cell carcinoma may not be ruled out.

A Rare Case of Primary Neuroendocrine Carcinomas in the Ear and Throat and Review of Literatures

“…It is proposed that ear NECs might originate from carcinogenesis caused by chemotherapy on the surrounding lesions. 16 Most physicians suggest that patients with poorly differentiated NECs receive radiotherapy and chemotherapy after surgery, which can improve their disease-free survival rates.…”

Adenomatous Tumors of the Middle Ear: A Literature Review

“…First described by Hyams and Michaels 1 in 1976, and afterwards by Murphy 2 in 1980, they still challenge pathologists and otolaryngologists in terms of their similarities to other rare pathologies, their etiologies, classification and prognosis. 3 Mostly limited to case reports and small series, the literature is poor in providing an overall assessment of these tumors. Some researchers insist that adenoma of the middle ear and carcinoid tumors are distinct biological neoplasms with similar characteristics; however, recent histopathologic evidence suggests that such labels can represent a spectrum of a common pathological entity.…”