Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners

Moriconi, Eleonora; Feraco, Alessandra; Marzolla, Vincenzo; Infante, Marco; Lombardo, Mauro; Fabbri, Andrea; Caprio, Massimiliano

doi:10.3389/fendo.2020.00444

Cited by 43 publications

(29 citation statements)

References 213 publications

(282 reference statements)

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“…In the current study, NSSs were found in one-fifth of the assessed 73,885 products, which is less than the 55% reported in a study in Chile [49], but much higher than the value found in studies conducted in Colombia, Brazil, Australia, and Hong Kong, where the proportion of products containing NSSs was no higher than 16% [18,19,50,51]. NSSs are usually added to products as (in part) a replacement for added sugars in response to emerging sugar reduction policies and increasing consumer concern regarding added sugars [52], but their impact on health remains controversial [53]. It was reported by WHO that replacing sugars with NSSs in the short term results in reductions in body weight, but may be associated with increased risk of type 2 diabetes, cardiovascular diseases, and mortality in the longer term [54].…”

Section: Discussionmentioning

confidence: 94%

Nutritional Quality of Pre-Packaged Foods in China under Various Nutrient Profile Models

Wang

Zhang

et al. 2022

Nutrients

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This study used various nutrient profile models (NPMs) to evaluate the nutritional quality of pre-packaged foods in China to inform future food policy development. Nutrition data for pre-packaged foods were collected through FoodSwitch China in 2017–2020. The analyses included 73,885 pre-packaged foods, including 8236 beverages and 65,649 foods. Processed foods (PFs) and ultra-processed foods (UPFs) accounted for 8222 (11.4%) and 47,003 (63.6%) of all products, respectively. Among the 55,425 PFs and UPFs, the overall proportion of products with an excessive quantity of at least one negative nutrient was 86.0% according to the Chilean NPM (2019), 83.3% for the Pan American Health Organization NPM (PAHO NPM), and 90.6% for the Western Pacific Region NPM for protecting children from food marketing (WPHO NPM), respectively. In all NPMs, 70.4% of PFs and UPFs were identified as containing an excessive quantity of at least one negative nutrient, with higher proportions of UPFs compared to PFs. Food groups exceeding nutrient thresholds in most NPMs included snack foods, meat and meat products, bread and bakery products, non-alcoholic beverages, confectionery, and convenience foods. In conclusion, PFs and UPFs accounted for three-fourths of pre-packaged foods in China, and the majority of PFs and UPFs exceeded the threshold for at least one negative nutrient under all three NPMs. Given the need to prevent obesity and other diet-related chronic diseases, efforts are warranted to improve the healthiness of foods in China through evidence-based food policy.

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Section: Discussionmentioning

confidence: 94%

Nutritional Quality of Pre-Packaged Foods in China under Various Nutrient Profile Models

Wang

Zhang

et al. 2022

Nutrients

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“…Recommended water intake was at least 2.5 lt/day. To avoid micronutrient deficiencies, mineral and vitamin supplements were recommended and only erythritol or steviol glycosides were allowed as sweeteners [28]. The maximal duration of the first two phases (ketosis phases) was 3 months (T1).…”

Section: Nutritional Interventionmentioning

confidence: 99%

Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes

et al. 2021

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Obesity-related type 2 diabetes represents one of the most difficult challenges for the healthcare system. This retrospective study aims to determine the efficacy, safety and durability of a very-low-calorie ketogenic diet (VLCKD), compared to a standard low-calorie diet (LCD) on weight-loss, glycemic management, eating behavior and quality of life in patients with type 2 diabetes (T2DM) and obesity. Thirty patients with obesity and T2DM, aged between 35 and 75 years, who met the inclusion criteria and accepted to adhere to a VLCKD or a LCD nutritional program, were consecutively selected from our electronic database. Fifteen patients followed a structured VLCKD protocol, fifteen followed a classical LCD. At the beginning of the nutritional protocol, all patients were asked to stop any antidiabetic medications, with the exception of metformin. Data were collected at baseline and after 3 (T1) and 12 (T2) months. At T1 and T2, BMI was significantly reduced in the VLCKD group (p < 0.001), whereas it remained substantially unchanged in the LCD group. HbA1c was significantly reduced in the VLCKD group (p = 0.002), whereas a slight, although not significant, decrease was observed in the LCD group. Quality of life and eating behavior scores were improved in the VLCKD group, whereas no significant changes were reported in the LCD group, both at T1 and T2. At the end of the study, in the VLCKD group 26.6% of patients had stopped all antidiabetic medications, and 73.3% were taking only metformin, whereas 46.6% of LCD patients had to increase antidiabetic medications. The study confirms a valuable therapeutic effect of VLCKD in the long-term management of obesity and T2DM and its potential contribution to remission of the disease.

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“…A recent publication showed that maternal NNS intake during pregnancy was associated with increased childhood body mass index (BMI) z-score and body fat from birth to teenage years [28]. Studies suggest that NNS may contribute to the development of metabolic syndrome and insulin resistance [29][30][31]. A systematic review and meta-analysis published in 2017 found that consumption of NNS was associated with hypertension, type 2 diabetes and cardiovascular events [30].…”

Section: Introductionmentioning

confidence: 99%

“…A systematic review and meta-analysis published in 2017 found that consumption of NNS was associated with hypertension, type 2 diabetes and cardiovascular events [30]. LNCS also interfere with gut microbiota composition [29,31,32].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Description of Foods with Low- and No-Calorie Sweeteners in Spain: The BADALI Project

et al. 2022

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The use of low- and no-calorie sweeteners (LNCS) in foods has increased in recent years in response to the negative effects of free sugar on health. However, the health impact of LNCS is still unclear. Studies of the prevalence of LNCS in foods have been published previously, including in Spain. However, the use of health (HCs) and nutrition claims (NCs) to promote these foods and a full nutritional characterization are largely lacking. For this purpose, we used the BADALI database with 4218 foods present in the Spanish market. Our results show that 9.3% of foods have LNCS (including both intense and polyols). Sucralose and acesulfame K were the intense sweeteners most frequently used (52.4% and 48.2%, respectively), whereas maltitol was the preferred polyol (20.3%). Of all foods with LNCS, 30% also had added sugar. Many more foods with LNCS presented HCs and NCs than those without. Sugar was the nutrient most frequently claimed in NCs for LNCS-containing foods, whereas vitamins were for those without these sweeteners. NCs compliance with regulation was similar in both conditions (60.1% for foods without and 63.9% for foods with LNCS). As expected, foods with LNCS had less total sugar content and energy. Surprisingly, the nutrient profile of yogurts with LNCS changed completely: less total and saturated fat, whereas more proteins and sodium. Biscuits with LNCS contained more fibre. The results of our study reveal that the prevalence of LNCS is becoming high in some food types in Spain and that foods containing LNCS are more frequently promoted with HCs/NCs. In addition, it confirms the general reduction in energy and sugar content expected in foods with LNCS. Furthermore, it suggests a reformulation of products beyond sugar content.

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Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners

Cited by 43 publications

References 213 publications

Nutritional Quality of Pre-Packaged Foods in China under Various Nutrient Profile Models

Nutritional Quality of Pre-Packaged Foods in China under Various Nutrient Profile Models

Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes

Nutritional Description of Foods with Low- and No-Calorie Sweeteners in Spain: The BADALI Project

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