Neuroendocrine and neuroimmune mechanisms underlying comorbidity of pain and obesity

Zhang, Dao-Han; Fan, Yong; Zhang, Yu‐Qiu; Chen, Hong

doi:10.1016/j.lfs.2023.121669

Cited by 8 publications

(4 citation statements)

References 135 publications

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“…Out of the 34 excluded articles, 24 were excluded because they were received or published before the last IASP definition revision (Andriessen et al, 2021;Asseyer et al, 2020;Cao et al, 2020;Carvajal, 2021;Cortes-Altamirano et al, 2020;Crispino & Ciccia, 2021;Della Pietra et al, 2020;Dermer et al, 2020;Ettlin et al, 2021;Kang et al, 2020;Maddern et al, 2020;Marques & Brefel-Courbon, 2021;Miller et al, 2020;Nie et al, 2021;Orhurhu et al, 2020;Reyes-Long et al, 2020;Sagi et al, 2020;Takeda & Shimazu, 2020;Urits et al, 2020;Vincent, 2020;X. Zhang & He, 2020), 7 were excluded because they were not on humans (Chen et al, 2022;Comes et al, 2021;Fakih et al, 2022;Gonçalves et al, 2022;Puja et al, 2021;Shinoda et al, 2022;D.-H. Zhang et al, 2023), 2 because they didn't provide any neurophysiological explanations (Coluzzi et al, 2020;Tueth & Duncan, 2021), and 1 because it wasn't written in English (Pongratz, 2021).…”

Section: Flowchartmentioning

confidence: 99%

Language errors in pain medicine: An umbrella review

Béraud,

Meichtry,

Hanusch

et al. 2024

Preprint

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Errors in language are common in pain medicine, but the extent of such errors has not been systematically measured. This pre-registered umbrella review explored Embase, PubMed, Medline and CINAHL and seeks to quantify the prevalence of language errors in review articles since the last IASP definition revision.Inclusion criteria comprised any type of review with a primary focus on providing neurophysiological insights into human nociception and/or pain within a pathological context, written in English and published in a peer-reviewed journal. Exclusion criteria involved articles published before the latest IASP definition revision, after May 2023, or listed on Beall's list. Statistical analyses employed Fisher exact tests for error proportions, while contrasted negative binomial models were applied for error counts. Out of 5,470 articles screened, 48 review articles met the inclusion criteria, each revealing at least one language error category. Years of publication were not associated with the presence of language errors or language error counts.Despite limitations like a limited number of studies, outlier, terminology ambiguity, an exclusive focus on human studies, and no risk of bias evaluation, this umbrella review shows a robust methodology and transparency with online available material. Considering our findings, urgent action is needed to regulate the use of misnomers in pain medicine and improve pain related terminology.Perspective: This umbrella review explored the main biomedical databases to see how many review articles contained language errors. Our findings underscore the imperative for prompt action in regulating pain medicine terminology.Pre-registration: This umbrella review was pre-registered on OSF registries (https://doi.org/10.17605/osf.io/kau8m).Online material: https://osf.io/kdweg/Keywords: Umbrella review - Language errors - Pain - Nociception – Terminology

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Section: Flowchartmentioning

confidence: 99%

Language errors in pain medicine: An umbrella review

Béraud,

Meichtry,

Hanusch

et al. 2024

Preprint

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“…Several factors contribute to this decrease, including the removal of or an alteration in the stomach and/or intestines during surgery, leading to a reduced population of cells capable of producing ghrelin and subsequent changes in plasma ghrelin concentration [116]. Changes in food digestion and absorption after surgery can also affect ghrelin secretion [117], while postoperative pain, stress, and inflammation may contribute to decreased ghrelin levels [118,119]. Notably, after Roux-en-Y gastric bypass (RYGB) bariatric surgery, increased ghrelin production is detected in the stomach, but no significant alteration in serum ghrelin is observed [120]; meanwhile, after single gastric bypass (OAGB), serum ghrelin secretion shows no significant difference [121].…”

Section: Ghrelin and Gi Surgerymentioning

confidence: 99%

Ghrelin in Focus: Dissecting Its Critical Roles in Gastrointestinal Pathologies and Therapies

Wu,

Zhu,

Dou

et al. 2024

CIMB

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This review elucidates the critical role of ghrelin, a peptide hormone mainly synthesized in the stomach in various gastrointestinal (GI) diseases. Ghrelin participates in diverse biological functions ranging from appetite regulation to impacting autophagy and apoptosis. In sepsis, it reduces intestinal barrier damage by inhibiting inflammatory responses, enhancing GI blood flow, and modulating cellular processes like autophagy and apoptosis. Notably, in inflammatory bowel disease (IBD), serum ghrelin levels serve as markers for distinguishing between active and remission phases, underscoring its potential in IBD treatment. In gastric cancer, ghrelin acts as an early risk marker, and due to its significant role in increasing the proliferation and migration of gastric cancer cells, the ghrelin–GHS-R axis is poised to become a target for gastric cancer treatment. The role of ghrelin in colorectal cancer (CRC) remains controversial; however, ghrelin analogs have demonstrated substantial benefits in treating cachexia associated with CRC, highlighting the therapeutic potential of ghrelin. Nonetheless, the complex interplay between ghrelin’s protective and potential tumorigenic effects necessitates a cautious approach to its therapeutic application. In post-GI surgery scenarios, ghrelin and its analogs could be instrumental in enhancing recovery and reducing complications. This article accentuates ghrelin’s multifunctionality, shedding light on its influence on disease mechanisms, including inflammatory responses and cancer progression, and examines its therapeutic potential in GI surgeries and disorders, advocating for continued research in this evolving field.

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“…One large-scale retrospective study found that obesity was an independent cause of postoperative pain requiring care [ 5 ]. In a review conducted in 2023 on obesity and pain, it was found that patients who have obesity are more likely to have increased pain sensitivity and altered pain threshold due to certain neuroendocrine mechanisms [ 6 ]. This may result in a low-grade inflammatory condition which is linked to the activity of white adipose tissue that is caused by chronic activation of both the innate and adaptive immune systems [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Depth of Anesthesia on Postoperative Pain in Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Trial

Zhang,

Chen,

Gao

et al. 2024

OBES SURG

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Background Patients with obesity are more sensitive to pain and more likely to have acute postoperative pain (APP). Studies have shown that the depth of anesthesia may affect the incidence of APP. The purpose of the study was to look into the connection between APP and depth of anesthesia in patients with obesity undergoing laparoscopic sleeve gastrectomy. Methods This is a prospective, double-blinded randomized clinical trial, 90 patients undergoing laparoscopic sleeve gastrectomy were randomly divided into two groups: the light anesthesia group (Bispectral Index of 50, BIS 50) and the deep anesthesia group (BIS 35). The degree of pain was evaluated by the visual analogue scale (VAS) at 0, 12, 24, 48, and 72 h after surgery. The use of analgesics, grade of postoperative nausea and vomiting (PONV), and the Quality of Recovery-15 (QoR-15) score were recorded. Results The VAS scores at rest or coughing at 0, 12, and 24 h after surgery in the BIS 35 group were lower than those in the BIS 50 group (P < 0.05). Fewer patients in the deep anesthesia group needed analgesia during the recovery period, and patient satisfaction was higher on the 3rd day after surgery (P < 0.015, P < 0.032, respectively). Conclusions For patients with obesity, maintaining a deeper depth of anesthesia during surgery is beneficial to reduce APP causes less need for additional analgesic drugs, and improves patient satisfaction. Graphical Abstract

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Neuroendocrine and neuroimmune mechanisms underlying comorbidity of pain and obesity

Cited by 8 publications

References 135 publications

Language errors in pain medicine: An umbrella review

Language errors in pain medicine: An umbrella review

Ghrelin in Focus: Dissecting Its Critical Roles in Gastrointestinal Pathologies and Therapies

The Effect of Depth of Anesthesia on Postoperative Pain in Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Trial

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