Neuroendocrine, appetitive and behavioural responses to d-fenfluramine in women recovered from anorexia nervosa

Ward, Anne; Brown, Nigel W.; Lightman, Stafford; Campbell, Iain C.; Treasure, Janet

doi:10.1192/bjp.172.4.351

Cited by 61 publications

(48 citation statements)

References 27 publications

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“…[13][14][15] In fact, most studies have shown that individuals with AN have disturbances of central serotonin activity, [15][16][17] which persist after recovery. [18][19][20] The opioid system has been implicated in the modulation of feeding behavior in which opioid agonists and antagonists were injected into animals. [21][22][23][24] Some clinical studies have suggested that opioid antagonists may have beneficial effects on eating behavior symptoms in patients with eating disorders.…”

Section: Introductionmentioning

confidence: 99%

Candidate genes for anorexia nervosa in the 1p33–36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa

et al. 2003

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Serotonergic and opioidergic neurotransmitter system alterations have been observed in people with eating disorders; the genes for the serotonin 1D receptor (HTR1D) and the opioid delta receptor (OPRD1) are found on chr1p36.3-34.3, a region identified by our group in a linkage analysis of anorexia nervosa (AN). These candidate genes were evaluated for sequence variation and for linkage and association of this sequence variation to AN in family and case : control data sets. Resequencing of the HTR1D locus and a portion of the OPRD1 locus identified novel SNPs and confirmed existing SNPs. Genotype assay development and genotyping of nine SNPs (four at HTR1D and five at OPRD1) was performed on 191 unrelated individuals fulfilling DSM-IV criteria (w/o amenorrhea criterion) for AN, 442 relatives of AN probands and 98 psychiatrically screened controls. Linkage analysis of these candidate gene SNPs with 33 microsatellite markers in families including relative pairs concordantly affected with restricting AN (N=37) substantially increased the evidence for linkage of this region to restricting AN to an NPL score of 3.91. Statistically significant genotypic, allelic, and haplotypic association to AN in the case : control design was observed at HTR1D and OPRD1 with effect sizes for individual SNPs of 2.63 (95% CI=1.21-5.75) for HTR1D and 1.61 (95% CI=1.11-2.44) for OPRD1. Using genotype data on parents and AN probands, three SNPs at HTR1D were found to exhibit significant transmission disequilibrium (Po0.05). The combined statistical genetic evidence suggests that HTR1D and OPRD1 or linked genes may be involved in the etiology of AN.

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Section: Introductionmentioning

confidence: 99%

Candidate genes for anorexia nervosa in the 1p33–36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa

et al. 2003

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“…In comparison, REC AN and BN subjects have higher than normal concentrations of CSF 5-HIAA, that is about 50% greater than CSF 5-HIAA levels found in the ill state ( Figure 1). In addition, REC AN and BN show altered behavioral responses to 5-HT challenges (65)(66)(67)(68) or other measures, such as platelet binding of paroxetine (69). As noted above, determining cause and effect is a major methodological confound in this illness.…”

Section: Serotoninmentioning

confidence: 99%

Neurobiology of anorexia and bulimia nervosa

Kaye

2008

Physiology & Behavior

527

369

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“…First, studies of women who have recovered from an eating disorder avoid the confounding effects of malnutrition on 5-HT activity. Second, some, but not all studies, showed that a disturbance of 5-HT activity persists after recovery from an eating disorder (Kaye et al, 1991;O'Dwyer et al, 1996;Ward et al, 1998). Finally, certain behaviors, such as anxiety, perfectionism, and obsessionality, have been found to occur premorbidly, and persist after recovery from AN (Bulik et al, 1997;Casper, 1990;Deep et al, 1995;Srinivasagam et al, 1995;Strober, 1980).…”

Section: Introductionmentioning

confidence: 99%

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Bailer

Price

Meltzer

et al. 2004

Neuropsychopharmacol

154

107

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Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5-HT 2A ) receptor, which could contribute to disturbances of appetite and behavior in AN and BN. To avoid the confounding effects of malnutrition, we studied 10 women recovered from bulimia-type AN (REC AN-BN, 41 year normal weight, regular menstrual cycles, no binging, or purging) compared with 16 healthy control women (CW) using PET imaging and a specific 5-HT 2A 18 F]altanserin binding potential and drive for thinness in several cortical regions. In conclusion, this study extends research suggesting that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions. Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders. It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects.

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Neuroendocrine, appetitive and behavioural responses to d-fenfluramine in women recovered from anorexia nervosa

Cited by 61 publications

References 27 publications

Candidate genes for anorexia nervosa in the 1p33–36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa

Candidate genes for anorexia nervosa in the 1p33–36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa

Neurobiology of anorexia and bulimia nervosa

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

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