Neuroendocrine cancers of the colon and rectum

Saclarides, Theodore J.; Szeluga, Debra J.; Staren, Edgar D.

doi:10.1007/bf02054405

Cited by 124 publications

(98 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, we collected clinical information on 48 patients having PD adenocarcinoma from 2204 colorectal cancer patients. Similar to previous reports (0.1-3.9%) (7)(8)(9)31,(34)(35)(36), the frequency of PD adenocarcinoma with NE cell differentiation was 0.36% and all of the PD adenocarcinomas with NE cell differentiation were localized only in the right colon and rectum. The overall survival rate was not significantly different between patients having PD adenocarcinoma with NE cell differentiation and patients having common PD adenocarcinoma; however, the frequency of liver metastasis at the time of diagnosis was significantly higher in patients having PD adenocarcinoma with NE cell differentiation.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis

Shinji

Naito²,

Ishiwata³

et al. 2006

Int J Oncol

View full text Add to dashboard Cite

Abstract. Poorly differentiated (PD) adenocarcinoma often retains the capacity for neuroendocrine (NE) cell differentiation; however, it is difficult to distinguish the NE cell differentiation by routine hematoxylin and eosin staining. It is important to detect the presence of NE cell differentiation in advanced colorectal carcinomas because these carcinomas have been shown to produce distant metastasis at the time of diagnosis and to have a particularly poor prognosis. In this study, the characteristics of PD adenocarcinoma with NE cell differentiation and its biological metastatic mechanisms were investigated. Forty-eight of 2204 colorectal cancer patients, diagnosed as having PD adenocarcinoma (2.2%) were enrolled in this study. Immunohistochemical analysis was performed with anti-chromogranin A anti-synaptophysin, anti-CD34, anti-D2-40, and anti-VEGF antibodies. The clinicopathological factors for PD adenocarcinoma with NE cell differentiation were compared with those for PD adenocarcinoma without NE cell differentiation. Microvessel density (MVD) was assessed using immunostained slides with anti-CD34 antibody and vascular endothelial growth factor (VEGF) expression in PD adenocarcinoma with NE cell differentiation was confirmed by in situ hybridization. By immunohistochemical staining for chromogranin A and synaptophysin, NE cell differentiation was detected in eight of 48 patients (16.7%) with PD adenocarcinoma. The frequency of liver metastasis at the time of diagnosis was significantly higher in patients having PD adenocarcinoma with NE cell differentiation (p=0.03). Moreover, MVD and VEGF expression level tended to be higher in patients having PD adenocarcinoma with NE cell differentiation (p=0.13 and 0.068, respectively). NE cell differentiation in PD adenocarcinoma may produce liver metastasis through microvessel formation in the tumor induced by VEGF. In PD colorectal adenocarcinoma, immunohistochemical analysis of NE markers is important for establishing the presence of NE cell differentiation and further study is necessary to evaluate the effectiveness of anti-angiogenic drugs to PD adenocarcinoma with NE cell differentiation.

show abstract

Section: Discussionsupporting

confidence: 91%

“…NE carcinomas in the colon and rectum are a heterogeneous group of tumors that display aggressive clinical behavior (6). Compared with common adenocarcinomas, NE carcinomas of the colon and rectum have a significantly poor prognosis (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis

Shinji

Naito²,

Ishiwata³

et al. 2006

Int J Oncol

View full text Add to dashboard Cite

show abstract

“…10,11,13,[22][23][24] Historic LCNEC series have suggested a natural aggressive course with a median survival < 1 year. 25,26 From a prognostic standpoint, LCNEC stage has been described as a major determinant for survival in most studies [27][28][29] but not in all studies. 21 More recently, the degree of endocrine differentiation, p16 expression, and c-kit expression were proposed as new prognostic parameters for survival.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary and extrapulmonary poorly differentiated large cell neuroendocrine carcinomas

Faggiano

Sabourin

Ducreux

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUND.Poorly differentiated large cell neuroendocrine carcinomas (LCNEC) comprise a rare and still scarcely known subgroup of neuroendocrine tumors. The objective of this study was to investigate the epidemiology, clinical presentation, prognostic factors, and molecular pathways of patients with poorly differentiated LCNEC.METHODS.Forty‐one patients who had a confirmed diagnosis of poorly differentiated LCNEC according to the criteria of the most recent World Health Organization classification of neuroendocrine tumors of the lung entered the study. The clinicopathologic features of patients with poorly differentiated LCNEC were reviewed, prognostic parameters for their survival were studied, and the prognostic roles of the proteins involved in cell cycle regulation were investigated with tissue array analysis in a subset of patients with LCNEC.RESULTS.Twenty‐four men and 17 women with a median age of 63 years (age range, 26–81 years) who had LCNEC were studied. LCNEC developed after therapy for a first cancer in 14% of patients. Neither a personal or familial history of endocrine tumors nor a primary association that was compatible with an inherited syndrome was observed. The increase of at least 1 serum biologic marker was observed in 93% of patients. A primary tumor was identified in only 63% patients. Thirty‐one patients had distant metastases, and 10 patients had only lymph node metastases at the time of the diagnosis. The 5‐year survival rate was 24%. High mitotic count, low expression of neuroendocrine markers, and a Bcl‐2/Bax ratio > 1 were unfavorable prognostic factors for survival (P < .01). All patients who had isolated peripheral lymph node LCNEC achieved a cure.CONCLUSIONS.The results from this study highlighted distinctive clinical features and prognostic indicators of poorly differentiated LCNEC. Peripheral isolated lymph node clinical presentation is proposed as a new clinical entity. Cancer 2007. © 2007 American Cancer Society.

show abstract

“…Clínicamente es indistingui-CARCINOMA DE CÉLULAS DE MERKEL EN LA REGIÓN PERIANAL. REPORTE DE UN CASO ble de otros cánceres cutáneos, siendo la histopatología el único método de diagnóstico 6 . Este tumor es altamente propenso a desarrollar recurrencia local (20-75%), metástasis regionales nodales (31-80%) y metástasis a distancia (26-75%) 7 , por lo que se cree que los pacientes con alto riesgo serían mejor manejados con terapia multimodal 8 .…”

Section: Discussionunclassified

Carcinoma de células de Merkel en la región perianal: Reporte de un caso

et al. 2009

Rev Chil Cir

View full text Add to dashboard Cite

Merkel cell carcinoma. Report of one caseMerkel cell carcinoma is a rare neuroendocrine tumor typically found on sun-exposed areas such as face and extremities. We report a 57 years old male presenting with a tumor in the left perianal region that prior to surgery was catalogued as a perianal teratoma. The pathological study informed a Merkel cell tumor. It was locally excised and a cutaneous flap was made. Two years after surgery, the patient had pulmonary metastases and chemotherapy was started. Due to lack of response, it was discontinued after four cycles.Key words: Merkel cell tumor, local excision, pulmonary metastases. ResumenLos tumores de células de Merkel, son raros tumores neuroendocrinos que típicamente son encontrados en zonas expuestas al sol como cara y extremidades. Describimos un caso de un paciente de 57 años de edad con una tumoración en la región perianal que inicialmente se catalogó como un teratoma, cuya histopatología informó un tumor de células de Merkel. Se manejo con resección local amplia y colgajo cutáneo. Después de 2 años de la cirugía, el paciente evolucionó con claros signos de enfermedad metastásica pulmonar y actualmente se encuentra en manejo paliativo con quimioterapia.Palabras clave: Tumor de células de Merkel, resección local, enfermedad metastásica. IntroducciónEl carcinoma de células de Merkel o carcinoma neuroendocrino cutáneo es un tumor poco frecuente y agresivo, asociado a una elevada tendencia a invasión ganglionar, recurrencia y metástasis a distancia. La etiología de éste, así como en muchos de los tumores cutáneos descritos, es desconocida. La hipótesis más aceptada es aquella que describe el efecto oncogénico de las radiaciones solares aso- CASOS CLÍNICOS

show abstract

Neuroendocrine cancers of the colon and rectum

Cited by 124 publications

References 7 publications

Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis

Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis

Pulmonary and extrapulmonary poorly differentiated large cell neuroendocrine carcinomas

Carcinoma de células de Merkel en la región perianal: Reporte de un caso

Contact Info

Product

Resources

About