Neuroendocrine carcinoma arising in soft tissue: three case reports and literature review

Hyer, Steve; McAleese, J.; Harmer, C.

doi:10.1186/1477-7819-5-77

Cited by 12 publications

(21 citation statements)

References 25 publications

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“…Primary or secondary soft tissue NETs of the lung or gastrointestinal tract are rare . In this case, because the patient wanted no further evaluation, the origin of the NET was not verified.…”

Section: Discussionmentioning

confidence: 92%

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Sonographic appearance of a neuroendocrine tumor arising in the axilla: Case report and literature review

Koo

Sohn

Park

2012

J of Clinical Ultrasound

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Section: Discussionmentioning

confidence: 92%

“…Recurrent tumors or aggressive histopathological types should be treated with curative radiotherapy. For patients who are not candidates for surgery or who have unresectable disease, radiotherapy could be an effective therapeutic option …”

Section: Discussionmentioning

confidence: 99%

Sonographic appearance of a neuroendocrine tumor arising in the axilla: Case report and literature review

Koo

Sohn

Park

2012

J of Clinical Ultrasound

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“…But when systemic progression and grade-4 toxicity presents after application of these two treatment lines we decided to request immunological therapy with Avelumab. Table 2: Primary cutaneous neuroendocrine tumours [16].…”

Section: Resultsmentioning

confidence: 99%

“…In some cases, tumor cells secrete serotonin and other vasoactive substances which produce a carcinoid syndrome characterized by: abdominal pain, skin redness, diarrhea, sweating, palpitations etc [16].…”

Section: Introductionmentioning

confidence: 99%

Primary Cutaneous Neuroendocrine Carcinoma: Case with an Atypical Location

G¹,

Castellon²

2017

CBT

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We present the case of a 60-year-old male with a primary cutaneous NET located in the sacro-coxigenic region without evidence of any distant disease at time of diagnosis. The diagnostic confirmation was based on immunohistochemical determination of Neuron-Specific Enolase (NSE) and Chromogranin A (Cg A). We surgically respected the tumor and because the resection margins were close, we also administered adjuvant radiotherapy. ConclusionNETs are rare, slow-growing tumors which usually have a good prognosis. Surgery with curative intent is the gold standard treatment, and this may or may be associated with adjuvant radiotherapy when adverse factors are presents or when the tumor is considered unrespectable. IntroductionPrimary cutaneous Neuroendocrine Tumor (NETs) is a very rare [1,2] with an approximate global incidence of 5.25 in 100,000 cases [3]: only ten cases have previously been reported in the literature [4][5][6][7][8][9][10][11][12][13]. These neoformations can vary enormously, both in their biological and clinical behavior, in terms of their which location, degree of differentiation and secretory activity [14,15]. Despite this, most are low-grade neoplasms with an indolent course.They are also called "carcinoid tumors" (well-differentiated neuroendocrine tumors) because they are characterized by the presence of neurosecretory granules which express specific markers, including Neuron-Specific Enolase (NSE), synaptophysin and Chromogranin A (Cg A) and CD56. In some cases, tumor cells secrete serotonin and other vasoactive substances which produce a carcinoid syndrome characterized by: abdominal pain, skin redness, diarrhea, sweating, palpitations etc [16].NETs are derived from neural crest neuroendocrine cells called Kulchitsky cells and give rise to tumors with very different degrees of differentiation, varying from carcinoid tumors to the undifferentiated small cell (oat-cell) carcinomas. They are formed by epithelial cells which exhibit neuroendocrine differentiation and can present in any anatomical location, although they usually appear in the face and trunk. Their etiology is unknown and there is no known association with sun exposure, immunodepression or other predisposing factors.The main diagnostic complexity in these cases lies in the distinction between primary cutaneous tumors and visceral neoplastic metastases because the latter may have a gastrointestinal or pulmonary origin but then cause cutaneous involvement. The mean age of presentation is between the sixth and ninth decade of life (mean 66.3 years) and studies have shown that the inicidence is similar between both sexes.We recently treated a patient with a primary cutaneous neuroendocrine carcinoma, a different entity to Merkel-Cell Carcinoma (MCC) whose primary location was the sacro-coxygeal región. Metastases in the right lateral costal area and nasal pyramid also subsequently emerged. Given the infrequency of these tumor types and the atypical location and behavior of this instance, here we describe our clinical experience of the ca...

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“…The most common sites of malignant neuroendocrine tumors are the appendix, rectum, ileum, and bronchi 39 38 , 40 …”

Section: Malignant Tumorous Conditionsmentioning

confidence: 99%

Sonographic Findings of Axillary Masses

Park¹,

Sohn²,

Kim³

2013

J of Ultrasound Medicine

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The diagnosis of axillary masses can be challenging because various tumors can develop in parts of the axilla other than lymph nodes, even though we frequently encounter axillary masses in daily practice. These lesions include soft tissue masses associated with nontumorous conditions (accessory breast tissue and chronic granulomatous inflammation) and benign and malignant tumorous conditions (lipomas, epidermal inclusion cysts, lymphangiomas, fibroadenomas, schwannomas, malignant neuroendocrine tumors, and lymph node-associated diseases). In this pictorial essay, we display commonly encountered sonographic findings of various axillary lesions to assist in the differential diagnosis of axillary masses.

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Neuroendocrine carcinoma arising in soft tissue: three case reports and literature review

Cited by 12 publications

References 25 publications

Sonographic appearance of a neuroendocrine tumor arising in the axilla: Case report and literature review

Sonographic appearance of a neuroendocrine tumor arising in the axilla: Case report and literature review

Primary Cutaneous Neuroendocrine Carcinoma: Case with an Atypical Location

Sonographic Findings of Axillary Masses

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