Neuroendocrine Control of the Menstrual Cycle

Hall, Janet E.

doi:10.1016/b978-0-323-47912-7.00007-x

Cited by 28 publications

(12 citation statements)

References 167 publications

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“…In adult women, high mid‐cycle estradiol concentrations (>200–300 pg/ml) trigger the gonadotropin surge—characterized by an approximately 10‐fold increase in LH and 4‐fold increase in FSH levels (Hall, 2018). In women, this phenomenon primarily appears to reflect an increase in pituitary gonadotropin responsiveness to GnRH release (Hall, 2018). As described above, the pre‐ovulatory increase in circulating progesterone may augment estradiol positive feedback at mid‐cycle (Chang & Jaffe, 1978; Liu & Yen, 1983), and some studies suggest that progesterone positive feedback is important for normal surge characteristics (e.g., surge latency period, surge duration, and FSH surge expression) (Chang & Jaffe, 1978; Liu & Yen, 1983; March et al, 1979; Taylor et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…If correct, this could represent another mechanism for ovulatory dysfunction in PCOS. In adult women, high mid-cycle estradiol concentrations (>200-300 pg/ml) trigger the gonadotropin surge-characterized by an approximately 10-fold increase in LH and 4-fold increase in FSH levels (Hall, 2018). In women, this phenomenon primarily appears to reflect an increase in pituitary gonadotropin responsiveness to GnRH release (Hall, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Kim

Lundgren

Patrie

et al. 2022

Physiological Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Kim

Lundgren

Patrie

et al. 2022

Physiological Reports

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“…While the rodent estrous cycle is similar to the human menstrual cycle, there are several key differences. Primarily, estrous cycles do not include the cyclical shedding of the uterine lining in the absence of pregnancy (menses), which is under the control of the hypothalamic pituitary gonadal (HPG) axis (Hall, 2019 ). Menstrual irregularities, which are mediated by the HPG axis, are associated with increased depression symptoms (Bisaga et al, 2002 ; Toffol et al, 2014 ), necessitating a different model to better understand the relationship between the menstrual cycle and anxiety in humans.…”

Section: Capturing Fear and Anxiety Across Species: The Value Of Nont...mentioning

confidence: 99%

Understanding the heterogeneity of anxiety using a translational neuroscience approach

Drzewiecki,

Fox

2024

Cogn Affect Behav Neurosci

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Anxiety disorders affect millions of people worldwide and present a challenge in neuroscience research because of their substantial heterogeneity in clinical presentation. While a great deal of progress has been made in understanding the neurobiology of fear and anxiety, these insights have not led to effective treatments. Understanding the relationship between phenotypic heterogeneity and the underlying biology is a critical first step in solving this problem. We show translation, reverse translation, and computational modeling can contribute to a refined, cross-species understanding of fear and anxiety as well as anxiety disorders. More specifically, we outline how animal models can be leveraged to develop testable hypotheses in humans by using targeted, cross-species approaches and ethologically informed behavioral paradigms. We discuss reverse translational approaches that can guide and prioritize animal research in nontraditional research species. Finally, we advocate for the use of computational models to harmonize cross-species and cross-methodology research into anxiety. Together, this translational neuroscience approach will help to bridge the widening gap between how we currently conceptualize and diagnose anxiety disorders, as well as aid in the discovery of better treatments for these conditions.

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“…Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play a complementary role in follicle development and ovulation. FSH initiates follicular growth, while LH acts at the follicle growth level, contributing to follicle maturation, fertilization and embryo quality ( 2 ). It affects the endometrium by promoting the decidualization of endometrial stromal cells and embryo implantation ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Luteinizing hormone supplementation in controlled ovarian stimulation: the Iran Delphi consensus

Salehpour,

Aleyasin,

Moini

et al. 2024

Front. Reprod. Health

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IntroductionNumerous consensus documents worldwide address luteinizing hormone (LH) supplementation in controlled ovarian stimulation, yet to the best of our knowledge, only one consensus paper has been published in the Arab region. This study presents a Delphi consensus by seven Iranian infertility experts, offering real-world clinical perspectives. The aim was to develop evidence-based opinions on LH's role alongside FSH in various aspects of assisted reproductive technology (ART), including LH levels, monitoring, r-hLH use, and suggested activity.MethodsEmploying the Delphi consensus approach, the Iran consensus unfolded in three steps. In Step 1, eight out of 10 statements gained approval, while two unclear statements were removed. In Step 2, the 20-member extended panel voted on the remaining eight statements.ResultsOnly one (statement 3) lacked consensus (55% agreement), prompting a modification. The revised statement (noted as statement 3′) obtained an 83% agreement.DiscussionThe clinical perspectives included in this consensus complement clinical guidelines and policies that help further improve treatment outcomes, especially for patients with FSH and LH deficiencies.

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Neuroendocrine Control of the Menstrual Cycle

Cited by 28 publications

References 167 publications

Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Understanding the heterogeneity of anxiety using a translational neuroscience approach

Luteinizing hormone supplementation in controlled ovarian stimulation: the Iran Delphi consensus

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