Neuroendocrine mechanisms for immune system regulation during stress in fish

Nardocci, Gino; Navarro, Cristina; Côrtes, Paula Pitta de Resende; Imarai, Mónica; Montoya, Margarita; Valenzuela, Beatriz; Jara, Pablo; Acuña-Castillo, Claudio; Fernández, Ricardo

doi:10.1016/j.fsi.2014.08.001

Cited by 145 publications

(69 citation statements)

References 102 publications

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“…Nevertheless, the exponential growth of aquaculture can be limited due to the increase in the organismsí disease susceptibility. This susceptibility is often induced by the presence of pesticides, substances that are used indiscriminately in agricultural activities and can induce alterations in the immune response of organisms such as fish (Nardocci et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus)

Toledo-Ibarra

Díaz-Reséndiz

Pavón

et al. 2016

Veterinary Immunology and Immunopathology

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Section: Discussionmentioning

confidence: 99%

Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus)

Toledo-Ibarra

Díaz-Reséndiz

Pavón

et al. 2016

Veterinary Immunology and Immunopathology

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“…It is uncertain whether the HPI axis, which is the main neuroendocrine regulation axis in fish and plays a central role in acclimation to stress, is also present in crustaceans. In fish, when an environmental stress signal is perceived, it can promote the release of CRH and ACTH into the circulation and further stimulate the release of cortisol (Nardocci et al, 2014). Importantly, Zhao et al (2016) reported that CRH-ACTH could induce the release of DA in L. vannamei.…”

Section: Evidence That Da Is Involved In the Regulation Of Neuroendocmentioning

confidence: 99%

Evidence that dopamine is involved in neuroendocrine regulation, gill intracellular signaling pathways and ion regulation in Litopenaeus vannamei

Pan

Zhang

et al. 2019

Journal of Experimental Biology

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The transport of ions and ammonia in gills may be regulated by neuroendocrine factors. In order to explore the mechanism of dopamine (DA) regulation, we investigated hemolymph neuroendocrine hormones, gill intracellular signaling pathways, ion and ammonia transporters, hemolymph osmolality and ammonia concentration in Litopenaeus vannamei after injection of 10 −7 and 10 −6 mol DA per shrimp. The data showed a significant increase in crustacean hyperglycemic hormone (CHH) concentration at 1-12 h and a transient significant decrease in corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and cortisol concentration under DA stimulation. The up-regulation of guanylyl cyclase (GC) mRNA, cyclic guanosine monophosphate (cGMP) and protein kinase G (PKG) concentration, together with the downregulation of DA receptor D 4 mRNA and up-regulation of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), diacylglycerol (DAG) and protein kinase C (PKC) concentration suggested the activation of complicated intracellular signaling pathways. The expression of cAMP response element-binding protein (CREB), FXYD2 and 14-3-3 protein mRNA was significantly increased by PKA regulation. The increase in Na + /K + -ATPase (NKA) activity and the stabilization of V-type H + -ATPase (V-rATPase) activity were accompanied by an up-regulation of K + channel, Na + / K + /2Cl − cotransporter (NKCC), Rh protein and vesicle associated membrane protein (VAMP) mRNA, resulting in an increase in hemolymph osmolality and a decrease in hemolymph ammonia concentration. These results suggest that DA stimulates the secretion of CHH and inhibits the release of cortisol, which activates intracellular signaling factors to facilitate ion and ammonia transport across the gills, and may not affect intracellular acidification.

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“…It produces animal protein on a large scale and at a fast pace. However, intensive fish farming causes great stress to animals, that is, osmoregulatory, metabolic and immunologic disorders, induced by the combined action of cortisol and catecholamines (Mommsen, Vijayan, & Moon, ; Nardocci et al, ; Tort, ; Urbinati, Zanuzzo, & Biller‐Takahashi, ; Wedemeyer, Barton, & McLeay, ). These disorders reduce immune responses, which results in infectious diseases that inhibit the effective development of fish farming (Plant & Lapatra, ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of immune response and performance of silver catfish fed functional linseed fibres in response to hypoxia stress

et al. 2019

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This study was conducted to evaluate the immunostimulating activity and growth promoting of diets supplemented with different rations of soluble and insoluble linseed fibre to Rhamdia quelen under hypoxia-induced acute stress. For this reason, soluble and insoluble fractions of linseed fibre were concentrated separately and combined into four ratios (1:0.5; 1:1; 1:2 and 1:4), which were added to the diets of silver catfish (6.43 ± 0.12 g) and evaluated in a biological assay, along with a control diet (without addition of linseed fibre). After being fed the experimental diets for 45 days, specimens of silver catfish were submitted to hypoxia-induced acute stress.They were kept out of water for 60 s. Immediately afterwards, blood and cutaneous mucus were collected for subsequent determination of immunological indicators and stress. After stress, the fish were weighed and measured for performance parameter calculation. The experimental design was completely randomized with five treatments and four replications. The data underwent analysis of variance and the means were compared by Tukey's test (p < .05). The fish fed diets containing the 1:2 and 1:4 soluble:insoluble fibre ratios, showed higher total protein content, globulin, plasma alkaline phosphatase activity, and performance in addition to higher mucoprotein content in the cutaneous mucus of the fish. Regardless of their ratio in the diet, linseed fibre provided higher plasma levels of total immunoglobulins and reduction in cortisol levels. The 1:1, 1:2 and 1:4 diets led to higher levels of total immunoglobulins and alkaline phosphatase activity in cutaneous mucus. The results indicate that linseed fibre has a stress-reduction, immunostimulant and a growth promoter effect on silver catfish. The 1:2 or 1:4 soluble: insoluble fibre ratios provided greater stimulation of the target immunological indicators and performance. K E Y W O R D S dietary fibre, immunostimulant, Rhamdia quelen, stress | 3061 ADORIAN et Al.

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Neuroendocrine mechanisms for immune system regulation during stress in fish

Cited by 145 publications

References 102 publications

Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus)

Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus)

Evidence that dopamine is involved in neuroendocrine regulation, gill intracellular signaling pathways and ion regulation in Litopenaeus vannamei

Evaluation of immune response and performance of silver catfish fed functional linseed fibres in response to hypoxia stress

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