Neuroendocrine regulation of energy balance: Implications on the development and surgical treatment of obesity

Farias, Gisele; Netto, Bárbara Dal Molin; Bettini, Solange Cravo; Dâmaso, Ana Raimunda; Freitas, Alexandre Coutinho Teixeira de

doi:10.1177/0260106017719369

Cited by 13 publications

(7 citation statements)

References 96 publications

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“…The release of ghrelin and therefore the increase of ghrelin plasma concentration promote feelings of hunger. When saturated, the plasma concentration of ghrelin decreases [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Insulin is produced in the pancreas as proinsulin and then cleavaged to a 51-amino-acid peptide and a C-peptide. The peptide hormone insulin is also part of food regulation, and its main function is to transport glucose from the blood into cells [12]. The distribution of insulin leads to a decrease in blood sugar levels and is therefore indispensable for the use of glucose as an energy source after meals [30].…”

Section: Introductionmentioning

confidence: 99%

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G-CuP: the effect of a forced oral glucose intake on alcohol craving and mesolimbic cue reactivity in alcohol dependence—study protocol of a randomized, double-blind, placebo-controlled crossover study

Wetzel

Pourbaix

Riegler

et al. 2022

Trials

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Background Multiple studies indicate that a lower plasma level of the acetylated form of the appetite-regulating hormone ghrelin and higher plasma levels of insulin lead to a reduction in subjective alcohol craving and a reduced mesolimbic cue reactivity in functional magnetic resonance imaging (fMRI) when being exposed to alcohol-associated stimuli. The ghrelin level can physiologically be reduced by the induction of stomach distension and the ingestion of glucose or lipids. Methods A total of 108 alcohol-dependent patients aged between 18 and 65 years are examined in the randomized, double-blind, placebo-controlled crossover study. After collecting demographic and psychometric data, participants take part in an alcohol exposure session. Afterwards, the participants go through the intervention condition (oral glucose intake) and the control condition (placebo intake) in a randomized order on two examination days. Blood samples are taken repeatedly (every 10 min) during the study course on both measuring days to determine changes in acetylated and total ghrelin and insulin plasma levels. In parallel, subjective alcohol craving after the glucose or placebo intake as the primary outcome is assessed using the Alcohol Urge Questionnaire (AUQ) and a visual analog scale (VAS). To examine the mesolimbic cue reactivity as the secondary outcome, a fMRI measurement is conducted while being exposed to alcohol-related stimuli. Appropriate statistical analysis will be used for the evaluation of the outcomes. Discussion If successful, the results of this study could offer alcohol-dependent patients a new potential option for acute short-term reduction of alcohol craving and thus prevent relapses and prolong periods of abstinence in the long term. Trial registration German Clinical Trials Register DRKS00022419 (UTN: U1111-1278-9428). Retrospectively registered on September 15, 2020.

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“…The release of ghrelin and therefore the increase of ghrelin plasma concentration promote feelings of hunger. When saturated, the plasma concentration of ghrelin decreases [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

G-CuP: the effect of a forced oral glucose intake on alcohol craving and mesolimbic cue reactivity in alcohol dependence—study protocol of a randomized, double-blind, placebo-controlled crossover study

Wetzel

Pourbaix

Riegler

et al. 2022

Trials

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show abstract

“…The sensation of hunger is the product of a complex interaction between the central nervous system, with a key role attributable to a series of hypothalamic nuclei, and a large number of hormones, many of which are secreted by the gastrointestinal tract [152].…”

Section: Neurohormonal Regulation Of Appetitementioning

confidence: 99%

Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review

et al. 2021

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The past few decades have shown a worrisome increase in the prevalence of obesity and its related illnesses. This increasing burden has a noteworthy impact on overall worldwide mortality and morbidity, with significant economic implications as well. The same trend is apparent regarding pediatric obesity. This is a particularly concerning aspect when considering the well-established link between cardiovascular disease and obesity, and the fact that childhood obesity frequently leads to adult obesity. Moreover, most obese adults have a history of excess weight starting in childhood. In addition, given the cumulative character of both time and severity of exposure to obesity as a risk factor for associated diseases, the repercussions of obesity prevalence and related morbidity could be exponential in time. The purpose of this review is to outline key aspects regarding the current knowledge on childhood and adolescent obesity as a cardiometabolic risk factor, as well as the most common etiological pathways involved in the development of weight excess and associated cardiovascular and metabolic diseases.

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“…El CA desde la perspectiva de la homeostasis conductual puede definirse como el conjunto de acciones que realiza un individuo para ingerir alimentos, en respuesta a una motivación biológica, psicológica y sociocultural 12 , donde el eje central de regulación es la regulación neuroendocrina a nivel hipotalámico 13,14 .…”

Section: El Estudio Del Comportamiento Alimentario (Ca)unclassified

Comportamiento alimentario en inmigrantes, aportes desde la evidencia

Hun

Urzúa

2019

Rev. chil. nutr.

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Neuroendocrine regulation of energy balance: Implications on the development and surgical treatment of obesity

Cited by 13 publications

References 96 publications

G-CuP: the effect of a forced oral glucose intake on alcohol craving and mesolimbic cue reactivity in alcohol dependence—study protocol of a randomized, double-blind, placebo-controlled crossover study

G-CuP: the effect of a forced oral glucose intake on alcohol craving and mesolimbic cue reactivity in alcohol dependence—study protocol of a randomized, double-blind, placebo-controlled crossover study

Causative Mechanisms of Childhood and Adolescent Obesity Leading to Adult Cardiometabolic Disease: A Literature Review

Comportamiento alimentario en inmigrantes, aportes desde la evidencia

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