Neuroendocrine tumor of the common hepatic duct, mimicking a choledochal cyst in a 6-year-old child

Tonnhofer, Ursula; Bálassy, Csilla; Reck, Carlos A.; Koller, Antje; Horcher, Ernst

doi:10.1016/j.jpedsurg.2009.03.030

Cited by 18 publications

(14 citation statements)

References 8 publications

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“…[21][22][23] The patients were all women, and the origin was the bile duct in 2 cases and the pancreas in the remaining case. The CCCs were classified as Todani type I or IV-A, implying the existence of PBM.…”

Section: Discussionmentioning

confidence: 99%

Well-Differentiated Endocrine Carcinoma Originating From the Bile Duct in Association With a Congenital Choledochal Cyst

Takahashi

Sasaki

Oshiro

et al. 2013

International Surgery

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We encountered a rare case of a well-differentiated endocrine carcinoma originating from the bile duct in association with a congenital choledochal cyst (CCC). The patient is a 28-year-old woman referred to our clinic for pruritus. Laboratory data showed mild elevation of serum hepatobiliary enzymes. Computed tomography and magnetic resonance imaging demonstrated pancreatobiliary maljunction and a Todani type IV-A CCC from the inferior bile duct to the bilateral intrahepatic bile ducts. A solid tumor was detected in the middle portion of the common bile duct. Pancreatoduodenectomy and total extrahepatic bile duct resection was performed. Based on pathologic and immunohistochemical examinations, a diagnosis of well-differentiated endocrine carcinoma was made according to the World Health Organization criteria. To our knowledge, this is the third report of a neuroendocrine tumor originating from the bile duct in association with a CCC.

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Section: Discussionmentioning

confidence: 99%

Well-Differentiated Endocrine Carcinoma Originating From the Bile Duct in Association With a Congenital Choledochal Cyst

Takahashi

Sasaki

Oshiro

et al. 2013

International Surgery

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“…Pruritus is known to be associated with malignancies in adults, however limited data is available in the pediatric population [1,2]. While there have been sporadic pediatric cases of itch associated with diagnosed neoplasms, no large study has examined this association within a pediatric population [8][9][10][11][12]. Our findings demonstrate associations between pruritus and malignancy in a diverse pediatric population at a USA tertiary care center.…”

Section: Discussionmentioning

confidence: 76%

“…Sporadic case reports have presented pediatric patients with pruritus who upon investigation were subsequently diagnosed with malignancies [8][9][10][11][12]. However, to our knowledge, no study has examined the association of itch and cancer or the types of underlying cancers associated with itch in a pediatric population.…”

Section: Introductionmentioning

confidence: 99%

Association between Itch and Cancer in 3836 Pediatric Pruritus Patients at a Tertiary Care Center

et al. 2019

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Background: Pruritus is a well-recognized paraneoplastic phenomenon. Previous studies have examined the association of itch with a variety of malignancies in adults. However, no large study has examined this association in a pediatric population. Methods: A retrospective study was conducted of patients age 18 or less seen at Johns Hopkins Health System between 2012 and 2019. Results: A pediatric hospital population of 1,042,976 patients was reviewed. Pruritus was observed in 3836 pediatric patients of whom 130 also had cancer. Pediatric patients with pruritus were significantly more likely to have concomitant malignancy compared to pediatric patients without pruritus (OR 12.84; 95% CI 10.73–15.35, p < 0.001). Malignancies most strongly associated with pruritus included neoplasms of the blood (OR 14.38; 95% CI 11.30–18.29, p < 0.001), bone (OR 29.02, 95% CI 18.28–46.06, p < 0.001) and skin (OR 22.76, 95% CI 9.14–56.72, p < 0.001. Conclusions: Pruritus is significantly associated with malignancy in the pediatric hospital population. Clinicians should also be aware of the high burden of itch in pediatric malignancies and the variation in pruritus across malignancies.

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“…To the best of our knowledge, sixty-three patients with NET arising from extrahepatic bile duct are reported whereas only 5 of those are in adolescence (2). The current study reports a case of a NET originating from extrahepatic bile duct and adds the sixth case to the literature.…”

Section: Introductionmentioning

confidence: 77%

A rare cause of bile duct obstruction in adolescence: Neuroendocrine tumor

Yalav

Ülkü²,

Demiryürek³

et al. 2015

Turk J Gastroenterol

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Extrahepatic bile duct is one of the rare places for neuroendocrine tumors which comprise 0.2-2 % off all neuroendocrine tumors of gastrointestinal tract. The aim of this paper is to report a case of a 16-year-old boy with a neuroendocrine tumor of extra hepatic bile duct. Laboratory and imaging findings is supported obstructive jaundice. After a pre-operative detailed evaluation, the common bile and common hepatic duct with gallbladder were resected and Roux-en-Y hepaticojejunostomy was performed. After a 36 months follow up, no locoregional recurrence or metastatic disease was observed. Pre-operative diagnosis of neuroendocrine tumors are extremely difficult and often confused with cholangiocarcinoma. Treatment modality of this rare entity depends on the location of the tumor and aggressive surgery is still the best chocie of treatment. It should be kept in mind that diseasefree survival for patients with neuroendocrine tumor depends on success of surgery.

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Neuroendocrine tumor of the common hepatic duct, mimicking a choledochal cyst in a 6-year-old child

Cited by 18 publications

References 8 publications

Well-Differentiated Endocrine Carcinoma Originating From the Bile Duct in Association With a Congenital Choledochal Cyst

Well-Differentiated Endocrine Carcinoma Originating From the Bile Duct in Association With a Congenital Choledochal Cyst

Association between Itch and Cancer in 3836 Pediatric Pruritus Patients at a Tertiary Care Center

A rare cause of bile duct obstruction in adolescence: Neuroendocrine tumor

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