Neuroendocrine Tumor of the Hilar Bile Duct

Umezaki, Naoki; Hashimoto, Daisuke; Yamashita, Yo‐ichi; Nakagawa, Shigeki; Nakao, Yousuke; Itoyama, Rumi; Yusa, Toshihiko; Yamao, Takanobu; Okabe, Hidetoshi; Imai, Katsunori; Hayashi, Hiromitsu; Chikamoto, Akira

doi:10.21873/anticanres.13192

Cited by 3 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only a few cases were diagnosed as NEC before surgery. [11][12][13] NECs are subclassified into small-cell and large-cell NECs with poor differentiation. [6][7][8] Most NECs of the extrahepatic bile duct cases were small-cell NECs.…”

Section: Discussionmentioning

confidence: 99%

“…9 The effectiveness of adjuvant and neoadjuvant chemotherapies is still difficult to assess because there are few treatment cases. [10][11][12][13]19,20 In summary, NECs of the extrahepatic bile duct are extremely rare and difficult to diagnose preoperatively. In addition, this disease can progress rapidly after surgical resection and has a poor prognosis.…”

Section: -18mentioning

confidence: 99%

See 1 more Smart Citation

Small-cell Neuroendocrine Carcinoma of the Extrahepatic Bile Duct: A Rare Case Report

Han

SEO

et al. 2023

Korean J Gastroenterol

View full text Add to dashboard Cite

Neuroendocrine carcinoma (NEC) arising from the extrahepatic bile duct is extremely rare and commonly mistaken for cholangiocarcinoma. Therefore, NEC of the bile duct is difficult to diagnose preoperatively. Previously reported cases were resected with a diagnosis of cholangiocarcinoma and diagnosed with NEC after surgery. This paper reports an 84-year-old female with small-cell NEC of the extrahepatic bile duct, confirmed by a biopsy from an ERCP, with a review of the relevant literature. Contrast-enhanced abdomen computed tomography and magnetic resonance cholangiopancreatography revealed an approximately 1.7 cm enhancing intraductal mass in the proximal common bile duct with dilatation of the upstream bile duct. ERCP showed a long strictured segment in the proximal common bile duct with bile duct dilatation. A biopsy was performed at the site of the stricture. Histological examinations and hematoxylin-eosin staining showed the solid proliferation of small tumor cells with irregularly shaped hyperchromatic nuclei. Immunohistochemical examinations showed that the tumor cells were positive for CD56 and synaptophysin. Small-cell NEC of the extrahepatic bile duct was confirmed based on the histology and immunohistochemistry findings. The patient and their family denied treatment because of the patient's old age.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: -18mentioning

confidence: 99%

Small-cell Neuroendocrine Carcinoma of the Extrahepatic Bile Duct: A Rare Case Report

Han

SEO

et al. 2023

Korean J Gastroenterol

View full text Add to dashboard Cite

show abstract

Primary neuroendocrine tumors and primary neuroendocrine carcinomas of the liver: a proposal for a multidiscipline definition

Torbenson¹,

Venkatesh²,

Halfdanarson³

et al. 2023

Human Pathology

View full text Add to dashboard Cite

Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016

Hua

et al. 2022

Current Oncology

View full text Add to dashboard Cite

Background: The main purpose of this study is to analyze the clinicopathological features and prognosis factors of bile duct and ampullary neuroendocrine neoplasms (NENs). Methods: The relevant data were collected from the SEER database from 1975 to 2016. The Kaplan–Meier curve and Cox model were used for survival analysis. The nomogram was drawn to predict the survival rate. The calibration, discrimination and clinical utility of the nomogram were evaluated by calibration curve, the concordance index (C-index) and decision curve analysis (DCA). Results: A total of 340 cases were included in our research. According to Kaplan–Meier analysis, 1-year, 3-year and 5-year of overall survival (OS) were 77.3%, 61.9% and 58.4%, while 1-year, 3-year and 5-year of the disease-specific survival (DSS) were 82.7%, 69.3% and 66.9%, respectively. The multivariable analysis results showed that age, histological grade, SEER stage and surgery were independent predictors for either OS or DSS. The calibration curve and the C-index value indicated that the nomogram was well calibrated and had good discrimination. DCA showed that the model had ideal net benefits. Conclusions: The age, histological grade, SEER stage and surgery were identified as independent prognostic variables for OS and DSS. After verification, nomogram has good predictive ability and clinical application value.

show abstract

Neuroendocrine Tumor of the Hilar Bile Duct

Cited by 3 publications

References 12 publications

Small-cell Neuroendocrine Carcinoma of the Extrahepatic Bile Duct: A Rare Case Report

Small-cell Neuroendocrine Carcinoma of the Extrahepatic Bile Duct: A Rare Case Report

Primary neuroendocrine tumors and primary neuroendocrine carcinomas of the liver: a proposal for a multidiscipline definition

Clinicopathological Features and Prognosis Analysis of Primary Bile Duct and Ampullary Neuroendocrine Neoplasms: A Population-Based Study from 1975 to 2016

Contact Info

Product

Resources

About