Neuroendocrine Tumors Arising in Meckel's Diverticula: Frequency of Advanced Disease Warrants Aggressive Management

Lorenzen, Allison W.; O’Dorisio, Thomas M.; Howe, James R.

doi:10.1007/s11605-013-2191-8

Cited by 24 publications

(21 citation statements)

References 24 publications

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“…(9) Although rarely seen, a large Meckel's diverticulum may invert within the distal ileum and cause obstruction. Carcinoid tumours arising within Meckel's diverticula are rare, (10) although they are the most commonly associated neoplasm. Malignant neoplasms arising from the diverticulum are extremely rare.…”

Section: Discussionmentioning

confidence: 99%

Clinics in diagnostic imaging (162)

Singh

Pulickal

et al. 2015

smedj

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A 28-year-old Chinese man presented with acute bleeding per rectum. Computed tomography showed a posterior outpouching arising from the distal ileum. The outpouching had hyperaemic walls, but no active contrast extravasation was detected. Technetium-99m pertechnetate scintigraphy showed focal areas of abnormal uptake in the right side of the pelvis, superior and posterior to the urinary bladder. These areas of uptake appeared simultaneously with the gastric uptake and demonstrated gradual increase in intensity on subsequent images. The diagnosis of Meckel's diverticulum was confirmed on surgery and the lesion was resected. The clinical and imaging features of Meckel's diverticulum are discussed.

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Section: Discussionmentioning

confidence: 99%

Clinics in diagnostic imaging (162)

Singh

Pulickal

et al. 2015

smedj

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“…Only short series (<10 patients) have been reported. 3,4 Three cases were discovered among 66 MD specimens resected in our centre between 1994 and 2015 (4.5%), the finding being incidental in two of these.…”

Section: Discussionmentioning

confidence: 94%

“…In our series, the malignancy rate was 4.5%, a little higher than rates reported by other authors. 1,3…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumours within a Meckel’s diverticulum

Mora-Guzmán

Martín-Pérez

2018

annals

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A Meckel's diverticulum is a common anomaly of the gastrointestinal tract. Although the majority of patients do not have any symptoms, malignancies can develop inside these diverticula, with neuroendocrine tumours being the most common. Diverticulectomy is the best option for complicated diverticula but prophylactic resection of asymptomatic diverticula in adults remains controversial. We present a case series of three patients with a neuroendocrine tumour found in a Meckel's diverticulum. Given the number of asymptomatic diverticula not resected, it seems likely that incidental neuroendocrine tumours are more prevalent than thought previously. With the minimally invasive techniques now available and the low complication rate for incidental diverticulectomy, we believe that the benefits of resection of this high risk area for cancer outweigh the risks of surgery.

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“…Most of them are benign tumours, such as adenomas, leiomyomas, angiomas and lipomas. Malignant neoplasms mainly include gastric adenocarcinomas, sarcomas and, rarely, gastrointestinal stromal tumours and different types of NETs[ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The development of a second primary malignancy in patients with these tumours is uncommon, but it has been described. However, coexistence of colon adenocarcinoma and intestinal GEP-NET arising in a Meckel’s diverticulum is very rare and represents diagnostic and therapeutic challenge[ 3 ]. We report a case of a patient with GEP-NET in Meckel’s diverticulum synchronous with metastatic colon cancer, all of which were resected during the same laparotomy, and discuss the clinical manifestations as well as the diagnostic procedures and treatment modalities used.…”

Section: Introductionmentioning

confidence: 99%

Gastroenteropancreatic neuroendocrine tumour arising in Meckel’s diverticulum coexisting with colon adenocarcinoma

et al. 2014

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Although colon cancer is the third most common cause of cancer-related death worldwide, the prevalence of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) remains rare. To date, very few cases of GEP-NETs within Meckel’s diverticulum and synchronous colorectal cancer have been reported. Although the coexistence of these two tumour types is uncommon, it is important to be aware of their disease patterns. We present a rare case of a patient with an intestinal GEP-NET arising in Meckel’s diverticulum coexisting with metastatic colon adenocarcinoma, and we discuss the clinical manifestations and the diagnostic procedures and treatment modalities used. This case report underlines the importance of being aware of this particular coexistence, as well as the unlikely metastatic spread of GEP-NETs and the importance of a multidisciplinary approach to cancer treatment. Finally, individualizing the treatment according to the stages of the primaries will result in durable cancer control, particularly in synchronous double malignancy.

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Neuroendocrine Tumors Arising in Meckel's Diverticula: Frequency of Advanced Disease Warrants Aggressive Management

Cited by 24 publications

References 24 publications

Clinics in diagnostic imaging (162)

Clinics in diagnostic imaging (162)

Neuroendocrine tumours within a Meckel’s diverticulum

Gastroenteropancreatic neuroendocrine tumour arising in Meckel’s diverticulum coexisting with colon adenocarcinoma

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