Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature

Grondin, Katherine; Lidang, Marianne; Boenelycke, Marie; Alvarado‐Cabrero, Isabel; Herrington, C. Simon; McCluggage, W. Glenn

doi:10.1097/pgp.0000000000000458

Cited by 19 publications

(11 citation statements)

References 17 publications

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“…The majority of identified cases published, however, have no associated tumor and thus another possibility is that they arise from neuroendocrine cells in the fallopian tube. Grondin et al Pathology of the Lower 8 stained 16 normal fallopian tubes and found that 9 of these stained positive for chromogranin within mucosal epithelial cells, giving support to this theory. An alternative is that another tumor was present and was completely overgrown by the neuroendocrine component.…”

Section: Discussionmentioning

confidence: 93%

“…Of these, primary fallopian tube NENs are so rare that the latest WHO Classification of female genital tumors does not list them as a separate category (1). Only a handful of cases have been reported in the literature (3)(4)(5)(6)(7)(8)(9)(10). We report a unique case of grade 2 primary NET within the fallopian tube and examine its clinical presentation, review the literature, and discuss the challenges in diagnosis and therapeutic management.…”

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confidence: 97%

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Rare Primary Fallopian Tube Grade 2 Neuroendocrine Tumor: A Case Report With Review of Literature

Kwon

Jorgensen

Vedere

et al. 2023

International Journal of Gynecological Pathology

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Neuroendocrine neoplasms commonly arise from the gastrointestinal tract and lungs. Less commonly, they may occur in the gynecologic tract, typically within the ovary of a mature cystic teratoma. Primary neuroendocrine neoplasms of the fallopian tube are exceptionally rare and only a total of 11 cases have been reported in the literature. We describe the first case to our knowledge of a primary grade 2 neuroendocrine tumor of the fallopian tube in a 47-yr-old female. In this report, we describe the case’s unique presentation, review the published literature on primary neuroendocrine neoplasms of the fallopian tube, discuss the treatment options, and speculate on their origin and histogenesis.

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Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 97%

Rare Primary Fallopian Tube Grade 2 Neuroendocrine Tumor: A Case Report With Review of Literature

Kwon

Jorgensen

Vedere

et al. 2023

International Journal of Gynecological Pathology

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“…Neuroendocrine tumors are rare at all locations in the female genital tract (39). Tubal involvement of high-grade neuroendocrine carcinoma of gynecological origin has been mentioned in only a few reports in the literature (39,40). In a recent case report, primary ovarian large cell neuroendocrine carcinoma (LCNEC) secondarily spread to the tubal mucosa (39).…”

Section: Figure 3 Histological Features and Immunophenotype Of Tubal Intraepithelial Metastases From Small Cell Neuroendocrine Carcinoma mentioning

confidence: 99%

Clinicopathological Characteristics of Microscopic Tubal Intraepithelial Metastases from Adenocarcinoma and Small Cell Neuroendocrine Carcinoma of the Uterine Cervix

Lee

Park

Woo

et al. 2021

In Vivo

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Background/Aim: Some metastatic tumors that involve the fallopian tube show intraepithelial spread, mimicking primary tubal neoplasm and representing a potential diagnostic pitfall. In this study, we aimed to investigate the clinicopathological characteristics of tubal intraepithelial metastasis (IEM) from cervical carcinoma. Patients and Methods: We analyzed the clinical features, histological features, and immunophenotypes of IEMs in five patients with cervical carcinoma. Results: This study included usual-type (1/5), mucinous-type (1/5), and gastrictype (2/5) endocervical adenocarcinomas and small cell neuroendocrine carcinoma (1/5) cases. None of the patients had ovarian metastasis, but metastatic tumor cells spread along the tubal mucosal surface and partially replaced the lining epithelium. Histological features of metastatic tumors closely resembled those of the primary tumors in all cases. Conclusion: Tubal IEM can mimic various tubal lesions including serous tubal intraepithelial carcinoma. Morphological consistency between the primary and metastatic tumors and immunostaining help guide the differential diagnosis of challenging intraepithelial lesions of the fallopian tube.Cervical carcinoma is one of the commonest causes of carcinoma-related mortality among women worldwide. The incidence and mortality rates of cervical carcinoma have decreased significantly in developed countries since the introduction of the cervicovaginal cytology screening program, which has facilitated the detection and treatment of precursor lesions (i.e. high-grade squamous intraepithelial lesion and adenocarcinoma in situ) (1). Despite the high efficacy of local treatment for the precursor lesions, treated women continue to represent a high-risk group, with high recurrence rates of 5-10% (2). Furthermore, despite increased surveillance, for several years after treatment, these women have a higher risk of invasive carcinoma than women in the general population (3). In 2018, approximately 570,000 women developed cervical carcinoma and 311,000 women died from it (4, 5).Squamous cell carcinoma is the commonest histological subtype arising in the uterine cervix, which accounts for 70% of all cervical carcinoma cases (6). Endocervical adenocarcinoma and high-grade neuroendocrine carcinoma comprise approximately 25% and 2%, respectively (6, 7). A recent large-scale study revealed that the most frequent anatomic site of metastatic cervical carcinoma was the lungs (37.9%), followed by the bone (16.7%), liver (12.5%), and brain (1.6%) (8). Adnexal metastasis of cervical carcinoma is relatively uncommon. The incidence of ovarian metastases ranges 2.0-28.6% and 0-17.4% for endocervical adenocarcinomas and squamous cell carcinomas, respectively. The clinicopathological characteristics of cervical carcinoma that involves the ovaries have been well documented (9), whereas only a few studies have investigated metastatic cervical carcinoma to the fallopian tube (10).Most of the tubal metastases from gynecological malignancies are associated with ...

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“…About two-thirds of NETs are GEP-NETs, mostly ariseing from the small intestine: small intestinal NETs are most frequently located in the distal ileum (4). On the other hand, as NE cells are distributed all around the body, there are many reports indicating diverse locations such as the sphenoid sinus (5), middle ear (6,7), renal pelvis (8), mediastinum (9), retroperitoneum (10), medulla spinalis (11), cavernous sinus (12), lymph nodes (13), fallopian tubes (14) and the parotid gland (15). NETs may be benign when small (usually <1 cm), but when malignant (representing less than 2% of gastrointestinal malignancies) they metastasise often before becoming symptomatic, generally when the tumour is larger than 2 cm.…”

Section: Epidemiology and Classificationmentioning

confidence: 99%

The Diagnosis of Neuroendocrine Tumours: An Endocrine Perspective

Çakır¹,

Grossman²

2018

Turk J Endocrinol Metab

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Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature

Cited by 19 publications

References 17 publications

Rare Primary Fallopian Tube Grade 2 Neuroendocrine Tumor: A Case Report With Review of Literature

Rare Primary Fallopian Tube Grade 2 Neuroendocrine Tumor: A Case Report With Review of Literature

Clinicopathological Characteristics of Microscopic Tubal Intraepithelial Metastases from Adenocarcinoma and Small Cell Neuroendocrine Carcinoma of the Uterine Cervix

The Diagnosis of Neuroendocrine Tumours: An Endocrine Perspective

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