Neuroendocrine tumors of the head and neck: SEER analysis of survival and incidence.

Zhu, Hong; Bacalao, Maria A.

doi:10.1200/jco.2015.33.15_suppl.e17051

Cited by 3 publications

(5 citation statements)

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“…6 , 8 There is limited data regarding the frequency, prognosis, and site of head and neck NENs. 9 A SEER database review by Khan et al 9 found that head and neck NEN survival varied significantly based on site and metastatic status, with oropharyngeal tumors having the poorest prognosis. A small case series of 14 patients with NENs of the head and neck by Mitchell et al 7 found that this subset of patients had better survival rates than NENs of the lung but worse survival rates when compared with squamous cell cancers of the head and neck.…”

Section: Discussionmentioning

confidence: 99%

Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature

Niforatos

Sandhu

Kallem

et al. 2022

Journal of Investigative Medicine High Impact Case Reports

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Head and neck tumors account for roughly 3% of malignancies in the United States and about 90% of these tumors are squamous cell cancers. Neuroendocrine neoplasms arise from neural crest cells and are commonly found in the gastrointestinal tract. Neuroendocrine neoplasms arising from the head and neck tend to be rare. In this article, we present a rare case of human papilloma virus–associated poorly differentiated small cell neuroendocrine carcinoma (NEC). Our patient was a 62-year-old African American man who presented with worsening left-sided neck pain and swelling that started 3 months prior to presentation, associated with an unintentional 20-pound weight loss over 6 months, hoarseness in his voice, in addition to dysphagia and odynophagia. Biopsy of left-sided tongue mass revealed poorly differentiated small cell NEC that was positive for HPV (E6/E7) RNA in situ hybridization. Patient was found to have metastatic disease at the time of diagnosis and given the aggressive nature of small cell NECs and the patient’s symptomatic burden, chemotherapy with cisplatin and etoposide was initiated in the hospital. The patient was subsequently discharged from the hospital and is continuing treatment outpatient with cisplatin, etoposide, and atezolizumab.

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Section: Discussionmentioning

confidence: 99%

Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature

Niforatos

Sandhu

Kallem

et al. 2022

Journal of Investigative Medicine High Impact Case Reports

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“…The World Health Organization (WHO) 2017 classification divided NET based on tumor differentiation into typical carcinoid (well-differentiated neuroendocrine carcinoma), atypical carcinoid (moderately differentiated neuroendocrine carcinoma), and poorly differentiated neuroendocrine carcinoma (small and large cell subtype) [7]. In a review of the Surveillance, Epidemiology and End Results (SEER) database between 1973 and 2011, only 56 cases of the carcinoid type out of 1,346 head and neck NETs identified were reported [1].…”

Section: Discussionmentioning

confidence: 99%

“…Neuroendocrine tumors (NETs) are a group of neoplasms with various clinical presentations and growth rates. Although rare, neuroendocrine carcinoma has been well-described in head and neck cancers [1]. Of all of the other types of NETs, well-differentiated NET, also known as typical carcinoid, is the least common in the head and neck and occurs most commonly in the supraglottic larynx [2].…”

Section: Introductionmentioning

confidence: 99%

Carcinoid Tumor Arising from the Sphenoid Sinus Treated with Definitive Intensity-modulated Radiation Therapy: A Case Report

Hilal

Jammal

Khalifeh

et al. 2019

Cureus

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Head and neck neuroendocrine tumors (NET) are a rare type of cancer. NET can be classified according to the histopathological features. The typical carcinoid tumor is a well-differentiated tumor that is the least common among other types. Owing to its indolent behavior and variable radiological and pathological features, treatment of carcinoid tumors remains a challenge. We report a case of a 54-year-old man presenting with a non-operable carcinoid tumor arising in the sphenoid sinuses treated with radiotherapy with stable disease control after three years follow-up.

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“…When NECs do occur within the head and neck, they tend to behave aggressively in a manner similar to that of high‐grade NECs in other organs, with early distant metastases and poor overall survival 4,5 . Within the head and neck, NECs are commonly found within the salivary glands, larynx, and nasopharynx, whereas paranasal sinuses and mouth/oropharynx are more rare 3,6 …”

Section: Introductionmentioning

confidence: 99%

“…4,5 Within the head and neck, NECs are commonly found within the salivary glands, larynx, and nasopharynx, whereas paranasal sinuses and mouth/oropharynx are more rare. 3,6 The vast majority of oropharyngeal cancers are of squamous cell histology, allowing the development of well-defined treatment paradigms for oropharyngeal squamous cell carcinomas (OPSCC). For advanced stage and metastatic OPSCC, the standard of care includes systemic chemotherapy, typically with a platinum-based regimen, and concurrent radiation therapy.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of neuroendocrine carcinomas of the oropharynx

et al. 2022

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Data describing features and management of oropharyngeal neuroendocrine carcinomas (NEC) remain sparse. A systematic review was performed. Patients were stratified by treatment modality and examined for disease progression and survival outcomes. Ninety‐four patients from 50 publications were included. Average age at diagnosis was 59.7 years (range 14–83). 73.4% were male. Most studies did not document HPV status. Forty patients (85.1%) were p16 positive, and 34 (85.0%) were HPV‐ISH positive. Overall survival was 75.4% at 1 year, and 40.0% at 2 years. Of patients with locoregional disease, 33.8% developed distant metastasis. 12.5% of patients developed locoregional recurrence. Patients who developed distant metastases had worse overall survival (p = 0.0004). No significant difference was found between treatment modalities. Human papilloma virus may be associated with oropharyngeal NEC. Current treatments provide locoregional control, but distant metastases are common and confer low overall survival.

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Neuroendocrine tumors of the head and neck: SEER analysis of survival and incidence.

Cited by 3 publications

References 0 publications

Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature

Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature

Carcinoid Tumor Arising from the Sphenoid Sinus Treated with Definitive Intensity-modulated Radiation Therapy: A Case Report

Systematic review of neuroendocrine carcinomas of the oropharynx

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