Neuroendocrine Tumors of the Liver and Pancreas Associated with Elevated Serum Prostatic Acid Phosphatase.

Kaneko, Yoshiyasu; Motoi, Noriko; Matsui, Atsushi; Motoi, Toru; Oka, Teruaki; Machinami, Rikuo; Kurokawa, Kiyoshi

doi:10.2169/internalmedicine.34.886

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Unexpectedly, recent studies have shown strong expression of PAP by breast cancer cells (24) and elevated levels of PAP in tumors of neuroendocrine origin (25). Whether this phenomenon gives an advantage to proliferating cells or is just an aberration of cancer biology remains an open question.…”

mentioning

confidence: 99%

Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design^,

2002

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The X-ray crystal structure of human prostatic acid phosphatase (PAP) in complex with a phosphate ion has been determined at 2.4 Å resolution. This structure offers a snapshot of the final intermediate in the catalytic mechanism and does not support the role of Asp 258 as a proton donor in catalysis. A total of eight hydrogen bonds serve to strongly bind the phosphate ion within the active site. Bound PEG molecules from the crystallization matrix have allowed the identification of a channel within the molecule that likely plays a role in molecular recognition and in macromolecular substrate selectivity. Additionally, the structure of PAP in complex with a phosphate derivative, α-benzylaminobenzylphosphonic acid, a potent inhibitor (IC50 = 4 nM), has been determined to 2.9 Å resolution. This structure gives new insight into the determinants of binding hydrophobic ligands within the active site and allows us to explain PAP's preference for aromatic substrates.

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mentioning

confidence: 99%

Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design^,

2002

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“…84,85 As there are few controlled studies, the potential usefulness of octreotide and interferons is currently speculative. [89][90][91] [89][90][91] …”

Section: Medical and Interventional Treatmentmentioning

confidence: 99%

Diagnosis and Management of Metastatic Gastrinoma by Multimodality Treatment Including Liver Transplantation: Report of a Case

et al. 1998

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Neuroendocrine tumors of the pancreas are being recognized with increasing frequency, not because the incidence has increased, but as a result of improvements in diagnostic tools such as radioimmunoassays for a variety of circulating peptides, and imaging methods that include positron emission tomography (PET) and immunoscintigraphy. Nevertheless, establishing the diagnosis of a neuroendocrine tumor is always a challenge to the clinician from both diagnostic and therapeutic perspectives. Liver transplantation as the ultimate therapeutic, or at least palliative, option for hepatic metastases has produced contradictory results over the past decade. We report herein the case of a 23-year-old woman who, after being diagnosed with gastrinoma in 1989, underwent the complete therapeutic array including liver transplantation for hepatic metastases in 1991. Although an extrahepatic tumor recurred 2 years later, for which double chemotherapy with 5-FU and streptozotocin was given, she is currently leading a normal life with a full-time job. This case prompted a critical review of the current literature on diagnosis and medical and surgical treatment.

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An HLA-A3-binding prostate acid phosphatase-derived peptide can induce CTLs restricted to HLA-A2 and -A24 alleles

Terasaki

Shichijo

Niu

et al. 2009

Cancer Immunol Immunother

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We previously reported peptide vaccine candidates for HLA-A3 supertype (-A3, -A11, -A31, -A33)-positive cancer patients. In the present study, we examined whether those peptides can also induce cytotoxic T lymphocyte (CTL) activity restricted to HLA-A2, HLA-A24, and HLA-A26 alleles. Fourteen peptides were screened for their binding activity to HLA-A*0201, -A*0206, -A*0207, -A*2402, and -A*2601 molecules and then tested for their ability to induce CTL activity in peripheral blood mononuclear cells (PBMCs) from prostate cancer patients. Among these peptides, one from the prostate acid phosphatase protein exhibited binding activity to HLA-A*0201, -A*0206, and -A*2402 molecules. In addition, PBMCs stimulated with this peptide showed that HLA-A2 or HLA-A24 restricted CTL activity. Their cytotoxicity toward cancer cells was ascribed to peptide-specific and CD8+ T cells. These results suggest that this peptide could be widely applicable as a peptide vaccine for HLA-A3 supertype-, HLA-A2-, and -A24-positive cancer patients.

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Neuroendocrine Tumors of the Liver and Pancreas Associated with Elevated Serum Prostatic Acid Phosphatase.

Cited by 5 publications

References 11 publications

Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design^,

Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design^,

Diagnosis and Management of Metastatic Gastrinoma by Multimodality Treatment Including Liver Transplantation: Report of a Case

An HLA-A3-binding prostate acid phosphatase-derived peptide can induce CTLs restricted to HLA-A2 and -A24 alleles

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Neuroendocrine Tumors of the Liver and Pancreas Associated with Elevated Serum Prostatic Acid Phosphatase.

Cited by 5 publications

References 11 publications

Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design,

Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design,

Diagnosis and Management of Metastatic Gastrinoma by Multimodality Treatment Including Liver Transplantation: Report of a Case

An HLA-A3-binding prostate acid phosphatase-derived peptide can induce CTLs restricted to HLA-A2 and -A24 alleles

Contact Info

Product

Resources

About

Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design^,

Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and α-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design^,