Neuroendocrinology and Neurochemistry of Maternal Motivation and Behavior

Lonstein, Joseph S.; Morrell, Joan I.

doi:10.1007/978-0-387-30405-2_5

Cited by 24 publications

(34 citation statements)

References 412 publications

(511 reference statements)

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“…In contrast, dams of the F1 generation developmentally exposed to either 2 or 200 mg BPS/kg/d spent significantly more time away from the nest on LD2 and LD7 compared with controls. During these early postpartum periods (LD2 and LD7), the pups require protection and constant care for their growth and survival, including attention to thermoregulation and feeding (71,72); thus, the F1 BPSexposed dams display quantitatively diminished care.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

Catanese

Vandenberg

2016

Endocrinology

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Estrogenic endocrine disrupting chemicals have been shown to disrupt maternal behavior in rodents. We investigated the effects of an emerging xenoestrogen, bisphenol S (BPS), on maternal behavior and brain in CD-1 mice exposed during pregnancy and lactation (F0 generation) and in female offspring exposed during gestation and perinatal development (F1 generation). We observed different effects in F0 and F1 dams for a number of components of maternal behavior, including time on the nest, time spent on nest building, latency to retrieve pups, and latency to retrieve the entire litter. We also characterized expression of estrogen receptor a in the medial preoptic area (MPOA) and quantified tyrosine hydroxylase immunoreactive cells in the ventral tegmental area, 2 brain regions critical for maternal care. BPS-treated females in the F0 generation had a statistically significant increase in estrogen receptor a expression in the caudal subregion of the central MPOA in a dose-dependent manner. In contrast, there were no statistically significant effects of BPS on the MPOA in F1 dams or the ventral tegmental area in either generation. This work demonstrates that BPS affects maternal behavior and brain with outcomes depending on generation, dose, and postpartum period. Many studies examining effects of endocrine disrupting chemicals view the mother as a means by which offspring can be exposed during critical periods of development. Here, we demonstrate that pregnancy and lactation are vulnerable periods for the mother. We also show that developmental BPS exposure alters maternal behavior later in adulthood. Both findings have potential public health implications. (Endocrinology 158: 516-530, 2017)

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Section: Discussionmentioning

confidence: 99%

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

Catanese

Vandenberg

2016

Endocrinology

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“…The neuroendocrinology and neurochemistry of maternal motivation has recently been reviewed quite thoroughly (Lonstein and Morrell, 2007), so the reader is referred to this excellent review for additional details. The hormones of pregnancy and parturition prime the brain for the onset of maternal behaviors, which begin at parturition as a consequence of the exposure to pups.…”

Section: Maternal Motivation: a Sexually Dimorphic Behaviormentioning

confidence: 99%

“…Female rats will cross electrified grids to gain access to pups (Lonstein and Morrell, 2007), and recently parturient female rats will readily learn to bar-press for access to pups, bar-pressing for hours, retrieving hundreds of pups (reviewed in (Lonstein and Morrell, 2007)). Operant responding has also been used to identify the areas of the brain that are necessary for bar-pressing for access to pups.…”

Section: Maternal Motivation: a Sexually Dimorphic Behaviormentioning

confidence: 99%

Sexual differentiation of motivation: A novel mechanism?

Becker

2009

Hormones and Behavior

115

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Sex differences in motivation are apparent for the motivation to engage in sexual behavior, the motivation to take drugs of abuse, and the motivation to engage in parental behavior. In both males and females there is an increase in NAcc DA associated with motivated behaviors. Here it proposed that sex differences in the regulation of DA activity in the ascending mesolimbic projections may underlie sex differences in motivation. In particular, sex differences in the neuroendocrine regulation of this brain system plays a role in the expression of sex differences in motivated behaviors. Here it is proposed that sexual differentiation of motivation is mediated, at least in part, by a novel mechanism in which ovarian hormones secreted at puberty in the female actively feminize the DA system.

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“…Algunos experimentos en ratas macho han demostrado que la activación de la oxitocina central es esencial para la regulación de la conducta sexual y que el incremento en los niveles de esta hormona durante la cópula está directamente asociado con la atenuación de conductas relacionadas con la ansiedad (25)(26)(27)(28).…”

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La separación materna durante la lactancia altera los niveles basales neuroendocrinos en ratas adolescentes y adultas

Riveros-Barrera

Dueñas

2015

biomedica

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: diseño del proyecto y los experimentos, y entrenamiento de Irene Riveros-Barrera Irene Riveros-Barrera: desarrollo de todos los experimentos Las dos autoras participaron en el análisis de datos y en la escritura del manuscrito. La separación materna durante la lactancia altera los niveles basales del sistema neuroendocrino en ratas adolescentes y adultasIrene Riveros-Barrera, Zulma DueñasDepartamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., ColombiaIntroducción. En diversos modelos animales, incluido el de la separación materna durante la lactancia, se ha demostrado que las experiencias tempranas adversas, como el maltrato, el abandono materno y el estrés psicosocial, pueden favorecer el desarrollo de algunas enfermedades mentales, pero no se han descrito completamente varios de los cambios que se producen en el sistema neuroendocrino. Objetivo. Determinar si la separación materna durante la lactancia modificaba los niveles basales de neurohormonas como la corticosterona, la corticotropina (ACTH), la oxitocina y la vasopresina (ADH), en ratas jóvenes (35 días) y adultas (90 días). Materiales y métodos. Se separaron ratas Wistar de sus madres durante dos periodos de tres horas diarias a lo largo de los 21 días de lactancia. A los 35 y 90 días se tomaron muestras de los grupos de las ratas de control y de las separadas de la madre, para obtener el suero y posteriormente medir cada una de las hormonas mediante un ensayo inmunoenzimático.Resultados. Las concentraciones de corticosterona fueron mayores en las hembras adultas de control que en el resto de los grupos, y menores en los machos adultos de control. Las de ACTH fueron mayores en los machos y hembras jóvenes separadas de la madre que en los grupos de adultos. Los niveles de oxitocina fueron significativamente mayores en las hembras adultas separadas de la madre que en los otros grupos y significativamente menores en los machos adultos. En cuanto a la vasopresina, los grupos separados de la madre tuvieron concentraciones menores, en comparación con los grupos de jóvenes y adultos de control. Conclusiones. Estos resultados muestran que el estrés temprano al que fueron sometidas las ratas, produjo cambios en las respuestas del eje hipotálamo-hipófisis-suprarrenal, las cuales variaron según el sexo y la edad.Palabras clave: lactancia materna, relación madre-hijo, corticosterona, hormona liberadora de corticotropina, oxitocina, arginina vasopresina, sistema hipófiso-suprarrenal.doi: http://dx.doi.org/10.7705/biomedica.v36i1.2830Maternal separation during nursing alters basal neuroendocrine levels in juvenile and adult rats Introduction: Work with different animal models including that of maternal separation during nursing has shown that early adverse experiences such as abuse, maternal abandonment and psychosocial stress may favor the development of various psychopathologies. However, several neuroendocrine changes have not been completely described yet. Objective: To establish whether maternal separation d...

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Neuroendocrinology and Neurochemistry of Maternal Motivation and Behavior

Cited by 24 publications

References 412 publications

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

Sexual differentiation of motivation: A novel mechanism?

La separación materna durante la lactancia altera los niveles basales neuroendocrinos en ratas adolescentes y adultas

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