Neuroendocrinology of Sleep

Steiger, A.

doi:10.1007/978-0-387-30405-2_25

Cited by 3 publications

(2 citation statements)

References 205 publications

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“…In Cushing's disease, SWS is decreased 70,71 with increased sleep latency, enhanced waketime, and REMS disturbances. In depressed patients in whom both cortisol and ACTH were elevated throughout the night an increased number of awakenings, early morning awakenings, decrease of NREMS, and REMS disinhibition 72 were observed.…”

Section: Cortisol Glucocorticoid and Mineralocorticoid Receptor Ligmentioning

confidence: 98%

“…On the basis of these findings, it is likely that TRH may contribute to the disturbed sleep continuity seen in depressed patients, probably acting in a synergistic manner with CRH. In patients with hyperthyroidism, SWS is reduced, 72 whereas in MDD, TRH administration may lead to slight sleep EEG alteration 128 or no alteration at all. 129 …”

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

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Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Kotronoulas

Stamatakis²,

Stylianopoulou³

2009

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Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms and functions of sleep remain without satisfactory responses. The purpose of this review is to report on current evidence as regards the effect of several endogenous and exogenous hormones, hormonal agents, and neuropeptides on sleep onset or wake process, when administered in humans in specific doses and via different routes. The actions of several peptides are presented in detail. Some of them (growth hormone releasing hormone, ghrelin, galanin, neuropeptide Y) seem to promote sleep, whereas others (corticotropin, somatostatin) impair its continuity.

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Section: Cortisol Glucocorticoid and Mineralocorticoid Receptor Ligmentioning

confidence: 98%

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Kotronoulas

Stamatakis²,

Stylianopoulou³

2009

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Stress Hormone Regulation: Biological Role and Translation into Therapy

Holsboer

Ising

2010

Annu. Rev. Psychol.

359

248

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Stress is defined as a state of perturbed homeostasis following endangerment that evokes manifold adaptive reactions, which are summarized as the stress response. In the case of mental stress, the adaptive response follows the perception of endangerment. Different peptides, steroids, and biogenic amines operate the stress response within the brain and also after they have been released into circulation. We focus in this review on the biological roles of corticosteroids, corticotrophin-releasing hormone (CRH), and arginine vasopressin (AVP), and we evaluate the effects of treatments directed against the actions of these hormones. CRH and AVP are the central drivers of the stress hormone system, but they also act as neuromodulators in the brain, affecting higher mental functions including emotion, cognition, and behavior. When released toward the pituitary, these central neuropeptides elicit corticotrophin into the periphery, which activates corticosteroid release from the adrenal cortex. These stress hormones are essential for the adequate adaptation to stress, but they can also evoke severe clinical conditions once persistently hypersecreted. Depression and anxiety disorders are prominent examples of stress-related disorders associated with an impaired regulation of stress hormones. We summarize the effects of drugs acting at specific targets of the stress hormone axis, and we discuss their potential use as next-generation antidepressant medications. Such treatments require the identification of patients that will optimally benefit from such specific interventions. These could be a first step into personalized medicine using treatments tailored to the specific pathology of the patients.

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Corticotropin-releasing factor signaling and visceral response to stress

Stengel

Taché

2010

Exp Biol Med (Maywood)

122

117

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Stress may cause behavioral and/or psychiatric manifestations such as anxiety and depression and also impact on the function of different visceral organs, namely the gastrointestinal and cardiovascular systems. During the past years substantial progress has been made in the understanding of the underlying mechanisms recruited by stressors. Activation of the corticotropin-releasing factor (CRF) signaling system is recognized to be involved in a large number of stress-related behavioral and somatic disorders. This review will outline the present knowledge on the distribution of the CRF system (ligands and receptors) expressed in the brain and peripheral viscera and its relevance in stress-induced alterations of gastrointestinal and cardiovascular functions and the therapeutic potential of CRF1 receptor antagonists.

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Neuroendocrinology of Sleep

Cited by 3 publications

References 205 publications

Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Stress Hormone Regulation: Biological Role and Translation into Therapy

Corticotropin-releasing factor signaling and visceral response to stress

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