Neurofeedback for Chemotherapy Induced Neuropathic Symptoms: A Case Study

Prinsloo, Sarah; Gabel, Stephanie; Data, Lauren; Lyle, Randall R.

doi:10.15540/nr.1.2.165

Cited by 3 publications

(7 citation statements)

References 13 publications

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“…The 6 included studies were published in English between 2013 and 2018 in 2 countries. Five of the studies were conducted in the United States 38 - 42 and one in the Netherlands. 43 The study by Prinsloo et al (2018) represents the follow-up analysis of the study published in 2017.…”

Section: Resultsmentioning

confidence: 99%

“…The other case report in a 60-year-old female breast cancer survivor was submitted by the authors (Prinsloo et al 42 ). Alleviation of chemotherapy-induced peripheral neuropathy was reported since NF.…”

Section: Resultsmentioning

confidence: 99%

“…40,41,43 The observational studies consisted of 1 prepost study 38 and 2 case reports. 39,42 Three studies reported on results of patients with breast cancer, 38,39,42 2 studies on populations with heterogeneous diverse cancer epidemiology, but more than 71% breast cancer survivors. 40,41 One study was conducted with pediatric brain tumor survivors.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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A Systematic Review of the Effect of Neurofeedback in Cancer Patients

et al. 2019

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Introduction: Neurofeedback (NF) or electroencephalogram (EEG)-Biofeedback is a drug-free form of brain training to directly alter the underlying neural mechanisms of cognition and behavior. It is a technique that measures a subject’s EEG signal, processes it in real time, with the goal to enable a behavioral modification by modulating brain activity. The most common application of the NF technology is in epilepsies, migraine, attention-deficit/hyperactivity disorder, autism spectrum disorder, affective disorders, and psychotic disorders. Few studies have investigated the use of NF in context of psychosomatic illnesses. Little is known about the use in cancer patients or postcancer survivors despite the high number of this patient group. Objectives: We here provide a systematic review of the use and effect of NF on symptoms and burden in cancer patients and long-term cancer survivors. Methods: In conducting this systematic review, we followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Statement. Results: Our search resulted in only 3 experimental studies, 1 observational study, and 2 case reports. Given the heterogeneity of the intervention systems and protocols, no meta-analysis was conducted. Conclusion: Altogether, there is initial evidence that NF is a complementary, drug-free, and noninvasive therapy that has the potential to ameliorate symptoms in this patient group, such as pain, fatigue, depression, and sleep. Further studies are highly needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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A Systematic Review of the Effect of Neurofeedback in Cancer Patients

et al. 2019

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“… 42 , 43 According to the theoretical assumptions, the alleviation of affective symptoms may be associated with an observed alpha increase after NF training. 15 …”

Section: Discussionmentioning

confidence: 99%

“…Over parietal and temporal areas, a psycho-oncological case study on visual neuropathic symptoms suggested that the observed alpha increase after NF training might be associated with the improvement of cancer-related symptoms. 15 Results on pain reduction could be found in a headache patient case study, 16 fibromyalgia, 17 trigeminal neuralgia, 18 and complex regional pain syndrome type I. 19 …”

Section: Introductionmentioning

confidence: 99%

Neurofeedback Treatment Affects Affective Symptoms, But Not Perceived Cognitive Impairment in Cancer Patients: Results of an Explorative Randomized Controlled Trial

et al. 2023

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Background: EEG biofeedback (NF) is an established therapy to enable individuals to influence their own cognitive-emotional state by addressing changes in brainwaves. Psycho-oncological approaches of NF in cancer patients are rare and effects are hardly studied. Objective: The aim of this explorative, randomized controlled trial was to test the effectiveness of an alpha and theta NF training protocol, compared to mindfulness based therapy as an established psycho-oncological treatment. Methods: Of initially 62 screened patients, 56 were included (inclusion criteria were cancer independent of tumor stage, age >18 years, German speaking; exclusion criteria suicidal ideation, brain tumor). Randomization and stratification (tumor stage) was conducted by a computer system. Participants got 10 sessions over 5 weeks, in (a) an NF intervention (n = 21; 13 female, 8 male; MAge = 52.95(10 519); range = 31 to 73 years)) or (b) a mindfulness group therapy as control condition (CG; n = 21; ie, 15 female, 6 male; MAge = 50.33(8708); range = 32 to 67 years)). Outcome parameters included self-reported cognitive impairment (PCI) as primary outcome, and secondary outcomes of emotional distress (DT, PHQ-8, GAD-7), fatigue (MFI-20), rumination (RSQ), quality of life (QoL, EORTC-30 QoL), self-efficacy (GSE), and changes in EEG alpha, and theta-beta band performance in the NF condition. Results: No changes in cognitive impairment were found ( P = .079), neither in NF nor CG. High affective distress was evident, with 70.7% showing elevated distress and 34.1% showing severe depressive symptoms. Affective symptoms of distress ( P ≤ .01), depression ( P ≤ .05) and generalized anxiety ( P ≤ .05) decreased significantly over time. No differences between NF and CG were found. There was a significant increase of the alpha band ( P ≤ .05; N = 15) over the NF sessions. Self-efficacy predicted QoL increase in NF with P ≤ .001 and an explained variance of 48.2%. Conclusion: This is the first study to investigate NF technique with regard to basic mechanisms of effectiveness in a sample of cancer patients, compared to an established psycho-oncological intervention in this field. Though there were no changes in cognitive impairment, present data show that NF improves affective symptoms comparably to mindfulness-based therapy and even more pronounced in QoL and self-efficacy. Trial registration: ID: DRKS00015773

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Neurofeedback Reduces P300 Amplitudes to Intensely Emotive Pictures in Depressed Cancer Patients

Krawutschke,

Teufel,

Schmidt

et al. 2024

Clin EEG Neurosci

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Objective. Electroencephalographic neurofeedback (EEG NF) or its effects on event-related potentials (ERPs) in quantitative EEG have not yet been systematically studied in cancer patients. The aim of this study was to investigate the emotional arousal and valence effects on the event-related P300 in a visual oddball paradigm by an individualized EEG alpha and theta/beta NF intervention in cancer patients and survivors ( N = 18, age between 31 and 73 years). Methods. ERPs to low and high arousal target stimuli with either emotional positive or negative content and depressive state were obtained in cancer patients before and after a five-week NF intervention in a waitlist paradigm, following the consensus on the reporting and experimental design of clinical and cognitive-behavioral NF studies (CRED-nf checklist). Results. Overall, P300 amplitudes decreased significantly ( p < .05) from pre to post therapy. Effects concerning high arousal stimuli with negative and positive valences were on the border to significance. Moreover, patients achieved significant relief of depressive symptoms ( p < .05). Especially younger participants (<55 yrs.) benefited. Conclusions. P300 observations could reflect a therapeutic effect on brain activity level. EEG NF alleviates depressive symptoms in cancer patients. Significance. Based on these findings, further studies are needed to investigate the effects on event-related potentials by NF therapy.

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Neurofeedback for Chemotherapy Induced Neuropathic Symptoms: A Case Study

Cited by 3 publications

References 13 publications

A Systematic Review of the Effect of Neurofeedback in Cancer Patients

A Systematic Review of the Effect of Neurofeedback in Cancer Patients

Neurofeedback Treatment Affects Affective Symptoms, But Not Perceived Cognitive Impairment in Cancer Patients: Results of an Explorative Randomized Controlled Trial

Neurofeedback Reduces P300 Amplitudes to Intensely Emotive Pictures in Depressed Cancer Patients

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