Neurofibroma paciniano: relato de um caso raro de localização intra-oral

Abstract

O neurofibroma paciniano é uma lesão rara encontrada predominantemente em mãos, incluindo digitais, em nádegas e pés. As lesões podem ser solitárias ou múltiplas como componente da doença de Von Recklinghausen. Na cavidade oral, o neurofibroma paciniano é um achado incomum, existindo apenas um caso relatado na literatura mundial. O objetivo deste trabalho é apresentar um caso de neurofibroma paciniano localizado em mucosa gengival, bem como descrever as suas características clínicas e histopatológicas, contribuindo, assim, para um melhor conhecimento desta entidade. PPaci nian Neurofibroma is a rare lesion that has been reported predominantly on the hand, including the digits, on buttocks and feet. The lesions can be solitaries or multiples as part of the Von Recklinghausen's disease. The intraoral site is unusual and just one case has been related in the world's literature. The purpose of this report is to present one case of pacinian neurofibroma and to describe its clinical and histopathological features contributing for the best knowledge about this entity. Rev Bras Otorrinolaringol. V.69, n.6, 851-4, nov./dez. 2003 Palavras-chave: neurofibroma, corpúsculos de Pacini, mucosa oral. Lélia CASE REPORT RELATO DE CASO

Expression of S-100, EMA, CD34 and presence of mast cells in eight oral neurofibromas, and a review of 127 cases of the literature

“…In addition, the cell nuclei and cytoplasm in the present study exhibited frequent variations in the staining intensity, which corroborates the findings of Nascimento et al (7) . Neurofibromas are immunopositive for the S-100 protein in 85% to 100% of the occasions (19,32) , although rare findings of negative S-100 immunostaining can occur (6) , as seen in one case in the present study. In our series, none of the cases exhibited spindle cells whose nuclei or cytoplasm stained positive for EMA.…”

Neurofibroma extra-ósseo solitário do palato duro

“…These clinical characteristics were seen in this case. NFs are immunopositive for the S-100 protein in 85 to 100% of the cases, indicating its neural origin 3,6 . Treatment for solitary NF is surgical excision and recurrence is rare 2,4 .…”

“…However, among neural lesions, this is the one that most frequently affects this region 1,2 . The NF can be intra or extra-osseous, alone or multiple (associated with type I neurofibromatosis) 2,3 . The most common extra-osseous mouth NF locations are tongue, oral mucosa and lips 2 .…”

Tumores nasossinusais raros: série de casos e revisão de literatura

“…The neurofibroma, a neoplasia originated from the Schwann cells, is the most common type, affecting most frequently the skin 23 . About 25% to 45% of neurofibromas happen in the head and neck, and only 4% involve the nasal cavity and paranasal sinuses 24 .…”

“…About 25% to 45% of neurofibromas happen in the head and neck, and only 4% involve the nasal cavity and paranasal sinuses 24 . It manifests as isolate lesion or multiple tumors, as it happens to the Type 1 neurofibromatosis (NF1) or Von Recklinghausen's disease 23 . Almost all patients with NF1 will develop a neurofibroma at some point in their lives 25 .…”