Neurofibromatosis of the Bladder in Children: Case Report and Literature Review

Abstract

A case of plexiform neurofibroma of the lower urinary tract is presented as well as a review of all previously reported cases in childhood. We suggest aggressive management in patients with diffuse disease.

Central Neurofibromatosis

“…Rodriguez and Berthrong [10] reviewed the literature in 1966 and they found 48 cases of NF-2 only with acoustic neuromas and multiple meningiomas, and other single case reports followed. On the other hand, visceral involvement is not [13] 1964 M/l positive peripheral deficit Clark et al [ 14] 1977 M/36 positive peripheral normal Holt [7] 1977 F/144 positive central -Rink and Mitchell [9] 1983 M/36 positive peripheral deficit F/60 negative peripheral deficit Present case 1990 F/96 negative central deficit frequent, either [7][8][9][11][12][13][14], Recently, Rink and Mitch ell [9] reviewed the literature, found 18 cases of urogeni tal neurofibromatosis in pediatric patients and added 2 of their own. Only 7 of the 20 patients were reported with genital involvement.…”

Bladder neurofibroma: a rare cause of pelvic mass

“…The incidence of systemic disease is 1 in every 3000 births; however, urogenital involvement is rare, and only about 70 cases with urinary manifestation have been described, in most cases featuring involvement of the bladder 2 . It is known that there is a 12 to 29% risk of malignant transformation and so follow-up with such patients is important, as is resection of the lesion whenever there is a suspicion of malignant transformation 3 . We present a rare case of a nerve sheath tumor of the bladder in a young patient presenting without any urinary symptoms.…”

Penile neurofibromas

“…*162200), only Fethiere et al [1974] have reported a patient with a penile schwannoma and other tumors suggestive of NF2 (NF2, MIM No.*101000). Among the different parts of the genitourinary tract, the bladder is most frequently involved [Clark et al, 1977;Elliott et al, 1981;Rink and Mitchell, 1983]. Although plexiform bladder neurofibromas (NFs) frequently encroach on other parts of the genitourinary tract and on adjacent tissues and organs, penile plexiform NFs are rare.…”