Neurofibromatosis type 1 and pregnancy complications: a population-based study

Terry, Anna R.; Barker, Fred G.; Leffert, Lisa; Bateman, Brian T.; Souter, Irene; Plotkin, Scott R.

doi:10.1016/j.ajog.2013.03.029

Cited by 54 publications

(52 citation statements)

References 24 publications

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“…17 Due to its broad representation of inpatient data and its nationally representative nature, this database has been the basis of numerous analyses related to outcomes, costs, and complications in a variety of disciplines. [18][19][20][21][22][23][24] The authors accessed the most recent block of years available describing inpatient admissions, from 2002 to 2010. We identified 12,938 patients with a primary diagnosis code of 227.3 ("benign pituitary neoplasm") who had undergone TSS with primary procedure codes 07.14, 07.62, 07.65.…”

Section: Methodsmentioning

confidence: 99%

Transsphenoidal surgery and diabetes mellitus: An analysis of inpatient data and complications

et al. 2015

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Section: Methodsmentioning

confidence: 99%

Transsphenoidal surgery and diabetes mellitus: An analysis of inpatient data and complications

et al. 2015

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“…17,18 Finally, our recent work on pregnancy outcomes suggests that phenomena such as preeclampsia and cerebrovascular disease are more common in NF1. 19 Given the prevalence of vasculopathy and cerebrovascular anomalies with NF1, an elevated risk of stroke has been postulated in previous research. Several case reports describe the link between stroke in NF1 patients with moyamoya syndrome [20][21][22] and other cerebral arteriopathies.…”

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confidence: 99%

Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1

Terry

Jordan

Schwamm

et al. 2016

Stroke

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Background and Purpose-Although neurofibromatosis type 1 (NF1) may be associated with an incompletely understood vasculopathy, relative odds of stroke in this population is not known. Methods-Using the 1998 to 2009 US Nationwide Inpatient Sample, we performed a case-control study matching cases of NF1 to controls without such a diagnosis. We then compared the odds of stroke between the 2 groups. We used multivariable logistic regression to adjust for known or suspected confounders. Results-NF1 was associated with younger mean age at the time of stroke (41 versus 48) and a lower prevalence of stroke risk factors among adult patients. Pediatric patients with NF1, however, were more likely to have hypertension. Patients with NF1 were significantly more likely to be diagnosed with any stroke (odds ratio, 1.2; P<0.0001) than the general population. The odds of intracerebral hemorrhage were greatest among hemorrhagic stroke types analyzed (odds ratio, 1.9; P<0.0001). In the pediatric NF1 population, the odds of intracerebral hemorrhage were more dramatically elevated (odds ratio, 8.1; P<0.0001). The odds of ischemic stroke were also increased with NF1 in the pediatric (odds ratio, 3.4; P<0.0001) but not in the adult population. Conclusions-When compared with the general population, the odds of any type of stroke are significantly increased for patients with NF1, both adult and pediatric. This risk is most notable for hemorrhagic strokes although it is also increased for ischemic strokes in children. Physicians should be aware of the increased risk of stroke in this population, and consider stroke as a potential cause of new neurological symptoms. (Stroke. 2016;47:60-65.

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“…NF1 leads to increased chances of preeclampsia, eclampsia, intrauterine growth retardation, spontaneous abortion, still birth, oligohydramnios and perinatal mortality [7]. Our patient had no antenatal records to prove antenatal complications except for her blood pressure on admission was 146/90 mm of Hg and she had a history of stillbirth in the past.…”

Section: Discussionmentioning

confidence: 78%

Pregnancy with Elephantiasis Neurofibromatosa—A Rare Presentation

Gupta¹,

Gupta²,

Sapre³

et al. 2014

OALib

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Neurofibromatosis (NF1) is an autosomal dominant disorder primarily affecting the development and growth of nerve cell tissues. We report a rare case of pregnancy with giant plexiform neurofibroma involving the genital tract with adverse perinatal outcome. A 26-year-old female presented at term in labour with NF1 and a huge plexiform neurofibroma arising from sacral region, gluteal region, pelvis and involving left labium majus. She delivered by cesarean section and the baby had congenital NF1. The baby expired on day 4 of life. To the best of our knowledge, this large size neurofibroma involving this site in pregnancy has never been reported in English literature. Both pregnancy and NF1 have reciprocal adverse effects on each other. Congenital neurofibromatosis can be fatal. Hence, all pregnancies associated with NF1 should be considered as high risk and monitored carefully.

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Neurofibromatosis type 1 and pregnancy complications: a population-based study

Cited by 54 publications

References 24 publications

Transsphenoidal surgery and diabetes mellitus: An analysis of inpatient data and complications

Transsphenoidal surgery and diabetes mellitus: An analysis of inpatient data and complications

Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1

Pregnancy with Elephantiasis Neurofibromatosa—A Rare Presentation

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