Neurofibromatosis Type 1 in Four Children Cases

Abstract

Neurofibromatosis Type 1 (NF-1 or Von Recklinghausen disease) is an autosomal dominant genetic disease, characterized by an extreme variability of its clinical expression which is also found in the same family. Our work focuses on the exploitation of four cases of patients with NF-1 who were enrolled in the paediatric neurology consultation at Rabat Children's Hospital. They are two infants and two children. Otherwise the diagnosis was made in front of the existence of café au lait and lentiginous spots in two boys, also the existence of café au lait spots and abnormalities in brain imaging in two girls. Thus an evolution was marked by a favorable outcome for three patients and neurological sequelae in one patient.

Neurofibromatosis Type 1 or Von Recklinghausen Disease: About Three Cases to the National Hospital of Niamey and Literature Review

“…Lisch nodules, were found in our 3 patients aged 14 and 30 years respectively, which is consistent with some studies that state that Lisch nodules are rare before six years, they are present in more than 90% of cases after 16 years [7] [15] [23]. Other manifestations such as optic tract glioma [24], lentigines, neurological, endocrine… were not detected.…”