Neurofibromatosis Type I: From Genetic Mutation to Tumor Formation

Thomas, Stacey L.; Vries, George H. De

doi:10.1007/978-0-387-30375-8_6

Cited by 3 publications

(2 citation statements)

References 160 publications

(189 reference statements)

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“…3 These tumors are associated with neurofibromatosis type 1 (NF1) (1,2), which is a human genetic disorder caused by mutations in the tumor suppressor gene that encodes the GTPase-activating protein neurofibromin. NF1-derived cell lines have elevated levels of receptors, such as the EGF receptor (3) and c-Kit (4), that typically are not expressed by Schwann cells.…”

Section: Neurofibromatosis Type 1-derived Schwann Cells Isolated Frommentioning

confidence: 99%

Platelet-derived Growth Factor-BB Activates Calcium/Calmodulin-dependent and -independent Mechanisms That Mediate Akt Phosphorylation in the Neurofibromin-deficient Human Schwann Cell Line ST88-14

Farrer

DeVries³

2013

Journal of Biological Chemistry

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Background: Malignant peripheral nerve sheath tumor (MPNST) cells overexpress PDGF receptor-␤, which increases intracellular calcium when activated. Results: Calcium/calmodulin (CaM) is involved in sustained phosphorylation of Akt and promotion of cell survival in an MPNST cell line. Conclusion: MPNST cells evade normal cell death through CaM-dependent sustained activation of Akt. Significance: Activation of CaM by abnormally expressed growth factor receptors may contribute to NF1 tumor formation.

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Section: Neurofibromatosis Type 1-derived Schwann Cells Isolated Frommentioning

confidence: 99%

Platelet-derived Growth Factor-BB Activates Calcium/Calmodulin-dependent and -independent Mechanisms That Mediate Akt Phosphorylation in the Neurofibromin-deficient Human Schwann Cell Line ST88-14

Farrer

DeVries³

2013

Journal of Biological Chemistry

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“…Our laboratory developed methods to isolate a fraction enriched in axolemma of peripheral nerves [22,70]. At this point in my career, a genetics graduate student (Karen Klein) joined my lab with a passion to study Schwann cells in the context of disease, particularly neurofibromatosis (a disease in which Schwann cells proliferate abnormally and form tumors) (see [71] for a recent review). As a result, we began a 15 year investigation by my lab into the signal transduction abnormalities which resulted in tumor formation by these aberrant Schwann cells [34,[47][48][49][72][73][74][75][76][77].…”

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confidence: 99%

A Career Perspective on the Discipline of Neurochemistry

DeVries

2008

Neurochem Res

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Glial Cell Lines: An Overview

Vries

Boullerne

2010

Neurochem Res

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The importance and essential functions of glial cells in the nervous system are now beginning to be understood and appreciated. Glial cell lines have been instrumental in the elucidation of many of these properties. In this Overview, the origin and properties of most of the existing cell lines for the major glial types: oligodendroglia, astroglia, microglia and Schwann cells, are documented. Particular emphasis is given to the culture conditions for each cell line and the degree to which the line can differentiate in vitro and in vivo. The major molecular markers for each glial cell lines are indicated. Finally, methods by which the glial cell lines have been developed are noted and the future directions of glial cell line research are discussed.

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Neurofibromatosis Type I: From Genetic Mutation to Tumor Formation

Cited by 3 publications

References 160 publications

Platelet-derived Growth Factor-BB Activates Calcium/Calmodulin-dependent and -independent Mechanisms That Mediate Akt Phosphorylation in the Neurofibromin-deficient Human Schwann Cell Line ST88-14

Platelet-derived Growth Factor-BB Activates Calcium/Calmodulin-dependent and -independent Mechanisms That Mediate Akt Phosphorylation in the Neurofibromin-deficient Human Schwann Cell Line ST88-14

A Career Perspective on the Discipline of Neurochemistry

Glial Cell Lines: An Overview

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