Neurofunctional correlates of attention rehabilitation in Parkinson’s disease: an explorative study

Cerasa, Antonio; Gioia, Maria Cecilia; Salsone, Maria; Donzuso, Giulia; Chiriaco, Carmelina; Realmuto, Sabrina; Nicoletti, Alessandra; Bellavia, G; Banco, A; D’Amelio, Marco; Zappia, Mario; Quattrone, Aldo

doi:10.1007/s10072-014-1666-z

Cited by 83 publications

(82 citation statements)

References 15 publications

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“…One low‐quality, exploratory study evaluated cognitive rehabilitation for improving cognitive impairment in PD patients receiving computer‐based cognitive training; some significant effects were reported. Because of the exploratory character of the study and the small sample size, the efficacy conclusion is “ insufficient evidence .” Because of the limited data available for MCI in PD, the practice implication is “ investigational .” Because of the lack of safety data, there is “ insufficient evidence ” to conclude on the safety of cognitive rehabilitation for cognitive impairment in PD.…”

Section: Results and Conclusionmentioning

confidence: 99%

Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review

et al. 2019

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Objective To update evidence‐based medicine recommendations for treating nonmotor symptoms in Parkinson's disease (PD). Background The International Parkinson and Movement Disorder Society Evidence‐Based Medicine Committee's recommendations for treatments of PD were first published in 2002, updated in 2011, and now updated again through December 31, 2016. Methods Level I studies testing pharmacological, surgical, or nonpharmacological interventions for the treatment of nonmotor symptoms in PD were reviewed. Criteria for inclusion and quality scoring were as previously reported. The disorders covered were a range of neuropsychiatric symptoms, autonomic dysfunction, disorders of sleep and wakefulness, pain, fatigue, impaired olfaction, and ophthalmologic dysfunction. Clinical efficacy, implications for clinical practice, and safety conclusions are reported. Results A total of 37 new studies qualified for review. There were no randomized controlled trials that met inclusion criteria for the treatment of anxiety disorders, rapid eye movement sleep behavior disorder, excessive sweating, impaired olfaction, or ophthalmologic dysfunction. We identified clinically useful or possibly useful interventions for the treatment of depression, apathy, impulse control and related disorders, dementia, psychosis, insomnia, daytime sleepiness, drooling, orthostatic hypotension, gastrointestinal dysfunction, urinary dysfunction, erectile dysfunction, fatigue, and pain. There were no clinically useful interventions identified to treat non‐dementia‐level cognitive impairment. Conclusions The evidence base for treating a range of nonmotor symptoms in PD has grown substantially in recent years. However, treatment options overall remain limited given the high prevalence and adverse impact of these disorders, so the development and testing of new treatments for nonmotor symptoms in PD remains a top priority. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Section: Results and Conclusionmentioning

confidence: 99%

Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review

et al. 2019

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“…Identification of processing speed deficits is particularly important since this construct has the potential to be modified with cognitive training [40–46]. Edwards et al [41] demonstrated that PD subjects could improve cognitive processing speed over a three-month period through a self-administered task using speed of processing training (SOPT) software (InSight).…”

Section: Discussionmentioning

confidence: 99%

Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson’s disease

Pal

O’Keefe

Robertson-Dick

et al. 2016

J NeuroEngineering Rehabil

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BackgroundOur primary objective was to determine the relationship between global cognitive function and specific domains of gait and balance in a cohort of Parkinson’s disease (PD) subjects. In a secondary analysis, we determined whether specific cognitive domains correlated with gait and balance performance.MethodsFourteen PD subjects (mean age 61.1 ± 7.8 years) were recruited from the Rush University Medical Center Movement Disorders clinic. Subjects underwent clinical assessment using the motor subsection of the Unified Parkinson’s Disease Rating Scale (UPDRS) followed by quantitative gait and balance assessments using the APDM Mobility Lab™ system (Mobility Lab, APDM Inc., Portland, OR). Subjects completed global cognitive testing using the Mattis Dementia Rating Scale (MDRS) as well as domain specific cognitive measures. Spearman’s rho was used to assess correlations between cognitive measures and gait and balance function, with False Discovery Rate (FDR) correction for multiple comparisons.ResultsGlobal cognitive function had the strongest correlation with stride velocity (r = 0.816, p = 0.001), turn duration (r = −0.806, p = 0.001), number of steps to turn (r = −0.830, p = 0.001), and mean velocity of postural sway in the medio-lateral direction (r = −0.726, p = 0.005). A significant correlation was found between processing speed and two turning measures (turn duration, r = −0.884, p = 0.001; number of steps to turn, r = −0.954, p < 0.001), but no other associations were found between specific cognitive domains and gait domains.ConclusionsThis pilot study provides preliminary data regarding the association between global cognitive function and pace-related measures of gait, turning, and postural sway. Furthermore, reduced processing speed was found to be associated with difficulty in performing turns.

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“…Cognitive rehabilitation programmes in PD have demonstrated their efficacy in improving a wide range of cognitive domains . Previous PD studies have also shown functional brain changes after cognitive rehabilitation in the short term . Recently, in a previous study from our group, patients with PD, after attending a 3‐month cognitive rehabilitation programme, demonstrated improvements in cognition and functional disability , which were accompanied by increased brain functional connectivity (FC) and activation .…”

Section: Introductionmentioning

confidence: 99%

Long‐term effects of cognitive rehabilitation on brain, functional outcome and cognition in Parkinson's disease

Díez‐Cirarda

Ojeda

Peña

et al. 2017

Euro J of Neurology

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Background and purposeCognitive rehabilitation has demonstrated efficacy in producing short‐term cognitive and brain changes in patients with Parkinson's disease (PD). To date, no study has assessed the long‐term effects of cognitive rehabilitation using neuroimaging techniques in PD. The aim was to assess the longitudinal effects of a 3‐month cognitive rehabilitation programme evaluating the cognitive, behavioural and neuroimaging changes after 18 months.MethodsFifteen patients with PD underwent a cognitive, behavioural and neuroimaging assessment at pre‐treatment (T0), post‐treatment (T1) and after 18 months (T2). This study examined the long‐term effects (from T0 to T2) and the maintenance of the changes (from T1 to T2). T1‐weighted, diffusion‐weighted, functional magnetic resonance imaging during both a resting‐state and a memory paradigm were acquired. Voxel‐based morphometry and tract‐based spatial statistics were used for grey and white matter analyses. A region‐of‐interest‐to‐region‐of‐interest approach was used for resting‐state functional connectivity (FC) and a model‐based approach was used for brain activation during the memory paradigm.ResultsPatients with PD showed increased cognitive performance, decreased functional disability, increased brain FC and activation at T2 compared with T0 (P < 0.05, FDR). Moreover, patients showed maintenance of the improvements in cognition and functionality, and maintenance of the increased brain FC and activation at T2 compared with T1. However, significant grey matter reduction and alterations of white matter integrity were found at T2 (P < 0.05, FWE).ConclusionsFindings suggest that the improved cognitive performance and increased brain FC and activation after cognitive rehabilitation were significantly maintained after 18 months in patients with PD, despite the structural brain changes, consistent with a progression of neurodegenerative processes.

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Neurofunctional correlates of attention rehabilitation in Parkinson’s disease: an explorative study

Cited by 83 publications

References 15 publications

Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review

Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review

Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson’s disease

Long‐term effects of cognitive rehabilitation on brain, functional outcome and cognition in Parkinson's disease

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