Neurog1, Neurod1, and Atoh1 are essential for spiral ganglia, cochlear nuclei, and cochlear hair cell development

Elliott, Karen L.; Pavlínková, Gabriela; Chizhikov, Victor V.; Yamoah, Ebenezer N.; Fritzsch, Bernd

doi:10.12703/r/10-47

Cited by 11 publications

(9 citation statements)

References 134 publications

(297 reference statements)

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“…neurod1, egr2b, tfap2a, and phox2a have been shown to be related to CNS development (Tahayato et al, 2003;Uehara et al, 2007;Zhang et al, 2017;Kousa et al, 2019;10.3389/fnins.2022.960149 FIGURE 4 The effect of loss of rnf2 on the specification of neural crest cells. Song et al, 2020;Elliott et al, 2021). The results showed that the expression of tfap2a was slightly reduced in rnf2 −/− embryos compared to controls, especially in the middle and hindbrain regions (Figure 6A).…”

Section: Rnf2 Loss Of Function Affects Central Nervous System Develop...mentioning

confidence: 83%

“…To this end, we performed in situ hybridization against neurod1 , egr2b , tfap2a , and phox2a in 48 hpf control and rnf2 mutant embryos ( Figure 6 ). neurod1 , egr2b , tfap2a , and phox2a have been shown to be related to CNS development ( Tahayato et al, 2003 ; Uehara et al, 2007 ; Zhang et al, 2017 ; Kousa et al, 2019 ; Song et al, 2020 ; Elliott et al, 2021 ). The results showed that the expression of tfap2a was slightly reduced in rnf2 –/– embryos compared to controls, especially in the middle and hindbrain regions ( Figure 6A ).…”

Section: Resultsmentioning

confidence: 99%

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The Polycomb group gene rnf2 is essential for central and enteric neural system development in zebrafish

Feng

Sun

2022

Front. Neurosci.

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The development of central nervous system (CNS) and enteric nervous system (ENS) is under precise and strict control in vertebrates. Whether and how the Polycomb repressive complex 1 (PRC1) is involved in it remain unclear. To investigate the role of PRC1 in the nervous system development, using CRISPR/Cas9 technology, we have generated mutant zebrafish lines for the rnf2 gene which encodes Ring1b, the enzymatic component of the PRC1 complex. We show that rnf2 loss of function leads to abnormal migration and differentiation of neural crest and neural precursor cells. rnf2 mutant embryos exhibit aganglionosis, in which the hindgut is devoid of neurons. In particular, the formation of 5-HT serotonin neurons and myelinating glial cells is defective. Furthermore, ectopic expression of ENS marker genes is observed in forebrain of rnf2 mutant embryos. These findings suggest that the rnf2 gene plays an important role in the migration and differentiation of neural precursor cells, and its absence leads to abnormal development of ENS and CNS in zebrafish.

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Section: Rnf2 Loss Of Function Affects Central Nervous System Develop...mentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

The Polycomb group gene rnf2 is essential for central and enteric neural system development in zebrafish

Feng

Sun

2022

Front. Neurosci.

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“…Neurod1 negatively regulates Atoh1 expression during cerebellum, and gut proliferation and manipulating Neurod1 expression that may help to counteract Medulloblastoma [ 67 , 68 , 69 , 70 ]. Atoh1 shows a much higher level of expression in the auditory nuclei and counteracts with Neurod1 , indicating a differential regulation of expression in auditory nuclei [ 71 ].…”

Section: Early Ear Placodal Development: From Unspecified Cells To Ne...mentioning

confidence: 99%

Early Steps towards Hearing: Placodes and Sensory Development

Zine

Fritzsch

2023

IJMS

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Sensorineural hearing loss is the most prevalent sensory deficit in humans. Most cases of hearing loss are due to the degeneration of key structures of the sensory pathway in the cochlea, such as the sensory hair cells, the primary auditory neurons, and their synaptic connection to the hair cells. Different cell-based strategies to replace damaged inner ear neurosensory tissue aiming at the restoration of regeneration or functional recovery are currently the subject of intensive research. Most of these cell-based treatment approaches require experimental in vitro models that rely on a fine understanding of the earliest morphogenetic steps that underlie the in vivo development of the inner ear since its initial induction from a common otic–epibranchial territory. This knowledge will be applied to various proposed experimental cell replacement strategies to either address the feasibility or identify novel therapeutic options for sensorineural hearing loss. In this review, we describe how ear and epibranchial placode development can be recapitulated by focusing on the cellular transformations that occur as the inner ear is converted from a thickening of the surface ectoderm next to the hindbrain known as the otic placode to an otocyst embedded in the head mesenchyme. Finally, we will highlight otic and epibranchial placode development and morphogenetic events towards progenitors of the inner ear and their neurosensory cell derivatives.

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“…A good example of this is the dA1 (Atoh1 +) domain in rhombomere 1 (upper rhombic lip). This domain generates: in addition to the parabrachial/Kölliker-Fuse complex, all excitatory deep cerebellar neurons, all cerebellar granule cell progenitors, as well as all cerebellar and cochlear unipolar brush cells ( Englund et al, 2006 ; Fink et al, 2006 ; Ray and Dymecki, 2009 ; Hernandez-Miranda et al, 2017a ; van der Heijden and Zoghbi, 2018 , 2020 ; Elliott et al, 2021 ; Lowenstein et al, 2021 , 2022 ; Fritzsch et al, 2022 ). How these progenitors generate such a vast array of neuron types is currently being investigated and appears to depend on the temporal expression of transcription factors that act as selector genes.…”

Section: Cell Lineages Contributing To Respiratory and Non-respirator...mentioning

confidence: 99%

Transcription factors regulating the specification of brainstem respiratory neurons

Xia

Cui

Alonso

et al. 2022

Front. Mol. Neurosci.

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Breathing (or respiration) is an unconscious and complex motor behavior which neuronal drive emerges from the brainstem. In simplistic terms, respiratory motor activity comprises two phases, inspiration (uptake of oxygen, O2) and expiration (release of carbon dioxide, CO2). Breathing is not rigid, but instead highly adaptable to external and internal physiological demands of the organism. The neurons that generate, monitor, and adjust breathing patterns locate to two major brainstem structures, the pons and medulla oblongata. Extensive research over the last three decades has begun to identify the developmental origins of most brainstem neurons that control different aspects of breathing. This research has also elucidated the transcriptional control that secures the specification of brainstem respiratory neurons. In this review, we aim to summarize our current knowledge on the transcriptional regulation that operates during the specification of respiratory neurons, and we will highlight the cell lineages that contribute to the central respiratory circuit. Lastly, we will discuss on genetic disturbances altering transcription factor regulation and their impact in hypoventilation disorders in humans.

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Neurog1, Neurod1, and Atoh1 are essential for spiral ganglia, cochlear nuclei, and cochlear hair cell development

Cited by 11 publications

References 134 publications

The Polycomb group gene rnf2 is essential for central and enteric neural system development in zebrafish

The Polycomb group gene rnf2 is essential for central and enteric neural system development in zebrafish

Early Steps towards Hearing: Placodes and Sensory Development

Transcription factors regulating the specification of brainstem respiratory neurons

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