Neurogenesis: A process ontogenically linked to brain cavities and their content, CSF

Gato, Á.; Alonso, Manuel García; Lamus, F.; Miyan, Jaleel

doi:10.1016/j.semcdb.2019.11.008

Cited by 14 publications

(9 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, meningeal cells organize the pial basement membrane, an extracellular matrix enriched in a variety of growth factors that covers the brain and might be involved in signaling at the basal side (Siegenthaler and Pleasure, 2011). Meanwhile, the apical side of embryonic and adult neural progenitors are in contact with the cerebrospinal fluid and the vascular system, and therefore might be influenced by extrinsic cues released from these non-neural tissues to regulate their self-renewal, differentiation and migratory capacity (Sawamoto et al, 2006;Tavazoie et al, 2008;Lehtinen and Walsh, 2011;Gato et al, 2019;Fame and Lehtinen, 2020). Indeed, isolated mouse apical progenitors cultured in vitro show only limited progression of temporal gene expression (Okamoto et al, 2016), suggesting that temporal progression in mammalian cortical progenitors may also require cell-extrinsic cues.…”

Section: Extrinsic Control Of Neural Progenitorsmentioning

confidence: 99%

Neurogenesis From Embryo to Adult – Lessons From Flies and Mice

Mira

Morante

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

The human brain is composed of billions of cells, including neurons and glia, with an undetermined number of subtypes. During the embryonic and early postnatal stages, the vast majority of these cells are generated from neural progenitors and stem cells located in all regions of the neural tube. A smaller number of neurons will continue to be generated throughout our lives, in localized neurogenic zones, mainly confined at least in rodents to the subependymal zone of the lateral ventricles and the subgranular zone of the hippocampal dentate gyrus. During neurogenesis, a combination of extrinsic cues interacting with temporal and regional intrinsic programs are thought to be critical for increasing neuronal diversity, but their underlying mechanisms need further elucidation. In this review, we discuss the recent findings in Drosophila and mammals on the types of cell division and cell interactions used by neural progenitors and stem cells to sustain neurogenesis, and how they are influenced by glia.

show abstract

Section: Extrinsic Control Of Neural Progenitorsmentioning

confidence: 99%

Neurogenesis From Embryo to Adult – Lessons From Flies and Mice

Mira

Morante

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…CSF-mediated signalling and neurogenesis are intimately linked processes with fundamental role in the development and homeostasis of the CNS. This is highlighted by the fact that neural precursors remain in close contact with CSF throughout life [168]. Neuroepithelium consisting of neuronal progenitors, which segregate to the ventricular zone upon neural tube closure and concomitant ventricular system formation, represent the chief source of cells that will give rise to the entire CNS [169].…”

Section: The Target Brain Regions Of Cp-csf Signallingmentioning

confidence: 99%

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

Kaiser

Bryja

2020

IJMS

View full text Add to dashboard Cite

Cerebrospinal fluid (CSF) is the liquid that fills the brain ventricles. CSF represents not only a mechanical brain protection but also a rich source of signalling factors modulating diverse processes during brain development and adulthood. The choroid plexus (CP) is a major source of CSF and as such it has recently emerged as an important mediator of extracellular signalling within the brain. Growing interest in the CP revealed its capacity to release a broad variety of bioactive molecules that, via CSF, regulate processes across the whole central nervous system (CNS). Moreover, CP has been also recognized as a sensor, responding to altered composition of CSF associated with changes in the patterns of CNS activity. In this review, we summarize the recent advances in our understanding of the CP as a signalling centre that mediates long-range communication in the CNS. By providing a detailed account of the CP secretory repertoire, we describe how the CP contributes to the regulation of the extracellular environment—in the context of both the embryonal as well as the adult CNS. We highlight the role of the CP as an important regulator of CNS function that acts via CSF-mediated signalling. Further studies of CP–CSF signalling hold the potential to provide key insights into the biology of the CNS, with implications for better understanding and treatment of neuropathological conditions.

show abstract

“…In vitro studies of adult human CSF treatment in neural stem cells showed that adult human CSF promoted gliogenesis, but not neurogenesis 55,56 . Despite ontogenetic differences in CSF protein composition in its ability to induce neurogenesis, the neurogenic potential is preserved in the adult mammalian brain and can be activated only by external stimuli including exercise, signalling molecules following injury or eCSF 6,57 . In contrast, in birds, neuronal cell proliferation occurs in the subventricular zone of the lateral ventricle, and migration to widespread regions of telencephalon follows 58 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Plasma and Cerebrospinal Fluid Proteomes Identifies Gene Products Guiding Adult Neurogenesis and Neural Differentiation in Birds

Voukali

Veetil

Němec

et al. 2021

Preprint

View full text Add to dashboard Cite

Cerebrospinal fluid (CSF) proteins regulate neurogenesis, brain homeostasis and participate in signalling during neuroinflammation. Even though birds represent valuable models for constitutive adult neurogenesis, current proteomic studies of the avian CSF are limited to chicken embryos. Here we use liquid chromatography–tandem mass spectrometry (nLC-MS/MS) to explore the proteomic composition of CSF and plasma in adult chickens (Gallus gallus) and evolutionarily derived parrots: budgerigar (Melopsittacus undulatus) and cockatiel (Nymphicus hollandicus). Because cockatiel lacks a complete genome information, we compared the cross-species protein identifications using the reference proteomes of three model avian species: chicken, budgerigar and zebra finch (Taeniopygia guttata) and found the highest identification rates when mapping against the phylogenetically closest species, the budgerigar. In total, we identified 483, 641 and 458 unique proteins consistently represented in the CSF and plasma of all chicken, budgerigar and cockatiel conspecifics, respectively. Comparative pathways analyses of CSF and blood plasma then indicated clusters of proteins involved in neurogenesis, neural development and neural differentiation overrepresented in CSF in each species. This study provides the first insight into the proteomics of adult avian CSF and plasma and brings novel evidence supporting the adult neurogenesis in birds.

show abstract

Neurogenesis: A process ontogenically linked to brain cavities and their content, CSF

Cited by 14 publications

References 79 publications

Neurogenesis From Embryo to Adult – Lessons From Flies and Mice

Neurogenesis From Embryo to Adult – Lessons From Flies and Mice

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

Comparison of Plasma and Cerebrospinal Fluid Proteomes Identifies Gene Products Guiding Adult Neurogenesis and Neural Differentiation in Birds

Contact Info

Product

Resources

About