Neurogenesis and Neuroplasticity in Major Depression: Its Therapeutic Implication

Bourin, Michel

doi:10.1007/978-981-33-6044-0_10

Cited by 8 publications

(3 citation statements)

References 77 publications

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“…Furthermore, impaired neurogenesis and neuroplasticity have also been observed in the brain of depressed patients, having been proposed as a major pathophysiological signature of MDD [ 48 ]. For instance, alterations in neurotrophic factors such as brain-derived neurotrophic factor (BDNF) or glial-derived neurotrophic factor (GDNF) are critically involved in these changes, affecting several cellular processes [ 49 , 50 ].…”

Section: Major Depressive Disorder and Diet: What Is The Relationship?mentioning

confidence: 99%

Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder

et al. 2022

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Major Depressive Disorder (MDD) is a growing disabling condition affecting around 280 million people worldwide. This complex entity is the result of the interplay between biological, psychological, and sociocultural factors, and compelling evidence suggests that MDD can be considered a disease that occurs as a consequence of an evolutionary mismatch and unhealthy lifestyle habits. In this context, diet is one of the core pillars of health, influencing multiple biological processes in the brain and the entire body. It seems that there is a bidirectional relationship between MDD and malnutrition, and depressed individuals often lack certain critical nutrients along with an aberrant dietary pattern. Thus, dietary interventions are one of the most promising tools to explore in the field of MDD, as there are a specific group of nutrients (i.e., omega 3, vitamins, polyphenols, and caffeine), foods (fish, nuts, seeds fruits, vegetables, coffee/tea, and fermented products) or dietary supplements (such as S-adenosylmethionine, acetyl carnitine, creatine, amino acids, etc.), which are being currently studied. Likewise, the entire nutritional context and the dietary pattern seem to be another potential area of study, and some strategies such as the Mediterranean diet have demonstrated some relevant benefits in patients with MDD; although, further efforts are still needed. In the present work, we will explore the state-of-the-art diet in the prevention and clinical support of MDD, focusing on the biological properties of its main nutrients, foods, and dietary patterns and their possible implications for these patients.

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Section: Major Depressive Disorder and Diet: What Is The Relationship?mentioning

confidence: 99%

Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder

et al. 2022

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“…An abnormal response to stress may lead to substantial changes in the different structures of the central nervous system, particularly in cortical brain areas (dorsal and medial prefrontal cortex, the dorsal and ventral anterior cingulate cortex, the orbital frontal cortex and the insula), subcortical limbic brain regions (hippocampus, amygdala and the dorsomedial thalamus), brainstem and basal ganglia, affecting their structure and functionalities and even their connectivity [ 52 ]. These regions show an impaired neurogenesis and neuroplasticity [ 53 ]. In accordance with this fact a disrupted activity of different neurotrophins such as brain-derived neurotrophic factor (BDNF), is frequently related to MDD and other psychiatric disorders, being responsible for orchestrating many critical neuronal processes (i.e., by promoting neural development, survival, neuroplasticity, and neurogenesis) [ 54 ].…”

Section: Mirnas Involved In the Pathogenesis Of Mddmentioning

confidence: 99%

MicroRNAs as Critical Biomarkers of Major Depressive Disorder: A Comprehensive Perspective

et al. 2021

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Major Depressive Disorder (MDD) represents a major global health concern, a body-mind malady of rising prevalence worldwide nowadays. The complex network of mechanisms involved in MDD pathophysiology is subjected to epigenetic changes modulated by microRNAs (miRNAs). Serum free or vesicles loaded miRNAs have starred numerous publications, denoting a key role in cell-cell communication, systematically and in brain structure and neuronal morphogenesis, activity and plasticity. Upregulated or downregulated expression of these signaling molecules may imply the impairment of genes implicated in pathways of MDD etiopathogenesis (neuroinflammation, brain-derived neurotrophic factor (BDNF), neurotransmitters, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, circadian rhythms...). In addition, these miRNAs could serve as potential biomarkers with diagnostic, prognostic and predictive value, allowing to classify severity of the disease or to make decisions in clinical management. They have been considered as promising therapy targets as well and may interfere with available antidepressant treatments. As epigenetic malleable regulators, we also conclude emphasizing lifestyle interventions with physical activity, mindfulness and diet, opening the door to new clinical management considerations.

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“…Therefore, patients with depression require support from their relatives and therapists, and very often pharmacological intervention [ 6 ]. In recent decades, a great deal of knowledge has been accumulated about the neurological mechanisms involved in depression, including the influence of inflammatory factors, the role of monoamines, and the influence of vascular disorders and genetics on the physiopathology of depression, regardless of environmental factors, eventually evolving to malfunction and/or damage to specific neural networks [ 7 , 8 , 9 , 10 , 11 ]. The datasets of gene regulation in depression is created and a combined portrait was created for men and women only [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

BDNF Impact on Biological Markers of Depression—Role of Physical Exercise and Training

Murawska-Ciałowicz

Ciałowicz

Assis

et al. 2021

IJERPH

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Depression is the most common and devastating psychiatric disorder in the world. Its symptoms, especially during the pandemic, are observed in all age groups. Exercise training (ET) is well known as a non-pharmacological strategy to alleviate clinical depression. The brain-derived neurotrophic factor (BDNF) is one of the biological factors whose expression and secretion are intensified in response to ET. BDNF is also secreted by contracted skeletal muscle that likely exerts para-, auto- and endocrine effects, supporting the crosstalk between skeletal muscle and other distant organs/tissues, such as the nervous system. This finding suggests that they communicate and work together to induce improvements on mood, cognition, and learning processes as BDNF is the main player in the neurogenesis, growth, and survival of neurons. Therefore, BDNF has been recognized as a therapeutic factor in clinical depression, especially in response to ET. The underlying mechanisms through which ET impacts depression are varied. The aim of this review was to provide information of the biological markers of depression such as monoamines, tryptophan, endocannabinoids, markers of inflammatory processes (oxidative stress and cytokines) stress and sex hormones and their relationship to BDNF. In addition, we reviewed the effects of ET on BNDF expression and how it impacts depression as well as the potential mechanisms mediating this process, providing a better understanding of underlying ET-related mechanisms in depression.

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Neurogenesis and Neuroplasticity in Major Depression: Its Therapeutic Implication

Cited by 8 publications

References 77 publications

Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder

Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder

MicroRNAs as Critical Biomarkers of Major Depressive Disorder: A Comprehensive Perspective

BDNF Impact on Biological Markers of Depression—Role of Physical Exercise and Training

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