Neurogenesis in a Marsupial: The Brush-Tailed Possum &lt;i&gt;(Trichosurus vulpecula)&lt;/i&gt;

Sanderson, K. J.; Aitkin, LM

doi:10.1159/000115878

Cited by 19 publications

(9 citation statements)

References 35 publications

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“…A detailed description of the methods we employed is provided in the companion paper [Sanderson and Aitkin, 1990] which reports on neurogenesis in visual and auditory regions from the same group of experimental animals. Some preliminary data on ncurogenesis in motor pathways have been presented previously [Sanderson, 1989].…”

Section: Methodsmentioning

confidence: 99%

“…The thalamic somatosensory relay nuclei (VL and VP) are being generated at the same time as are the thalamic auditory and visual relay nuclei, during the first 2 postnatal weeks [Sanderson and Aitkin, 1990]. In mice and rats these thalamic regions also develop contemporaneously [Angevine, 1970;Bayer, 1979a, b, 1989a-c].…”

Section: Timing Of Neurogenesis In the Sensorimotor Systemmentioning

confidence: 99%

“…Neurogenesis of visual and auditory centers in possums also shows these two patterns, with neurons in cortical regions being generated in the extended phase [Sanderson and Aitkin, 1990]. Retinal ganglion cells are also generated during this period [Harman et al, 1989].…”

Section: Timing Of Neurogenesis In the Sensorimotor Systemmentioning

confidence: 99%

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Neurogenesis in a Marsupial: The Brush-Tailed Possum <i>(Trichosurus vulpecula)</i>

Sanderson

Weller

1990

Brain Behav Evol

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The times of origin of neurons in sensorimotor pathways of the marsupial brush-tailed possum were determined with ³H-thymidine autoradiography. A series of 20 possums were injected with ³H-thymidine from postnatal days 5–95 and were normally allowed to survive until the brain cytoarchitecture was mature. Brain stem and spinal sensorimotor regions were not labelled in our study and presumably form before birth in order to enable the newborn young to make the journey from the birth canal to the pouch on its own. Neurogenesis in thalamic sensorimotor nuclei probably begins about the time of birth and continues into the 2nd week of postnatal life. Formation of neurons in the sensorimotor cortex and the basal ganglia occurs during the first 2 months of postnatal life and in the cerebellum during the first 3 months. This protracted postnatal development of telencephalic and cerebellar sensorimotor regions offers great advantages for developmental studies.

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Section: Methodsmentioning

confidence: 99%

Section: Timing Of Neurogenesis In the Sensorimotor Systemmentioning

confidence: 99%

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Neurogenesis in a Marsupial: The Brush-Tailed Possum <i>(Trichosurus vulpecula)</i>

Sanderson

Weller

1990

Brain Behav Evol

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“…Relatively little is known regarding adult neurogenesis in noneutherian mammalian groups. However, postnatal hippocampal neurogenesis has been demonstrated to occur well after the cessation of histogenesis in other brain regions in the brushtailed opossum (Trichosurus vulpecula, [66]). This unusual postnatal hippocampal ontogeny is reminiscent of species in which adult hippocampal neuron production has been well established, suggesting that adult hippocampal neurogenesis is characteristic of opossums and, perhaps, closely related marsupials.…”

Section: Adult Neurogenesis In the Mammalian Hippocampal Formationmentioning

confidence: 99%

Comparative Views of Adult Neurogenesis

2000

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Traditional views maintain that the generation of neurons within the mammalian brain is restricted to a discrete developmental period. This perspective has undergone significant revision during the later half of this century, culminating recently with the demonstration of neurogenesis in the brains of adult primates, including humans. Although it is becoming increasingly clear that adult neurogenesis represents an important mode of structural modification for the adult brain, its functional significance has not been determined. The production and survival of new neurons in the adult mammalian brain is regulated by both experiential and neuroendocrine factors, suggesting that adult-generated neurons may serve as a substrate by which these cues influence normal brain function. This article reviews significant advances that have led to the discovery of neurogenesis in adult mammals and examines comparative data suggesting that adult neurogenesis may play a role in certain forms of learning. Neural activity associated with behavioral experience is known to result in changes in brain structure and connectivity, for example, by modifying synapse number, axonal sprouting, dendrite length and branching, or synaptic strength. In the case of adult neurogenesis, experience may shape neural networks by directing the production and connectivity of whole cell populations. NEUROSCIENTIST 6(5): [315][316][317][318][319][320][321][322][323][324][325] 2000

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“…It receives afferent connections from virtually all brainstem auditory nuclei (for review, see Aitkin, 1986) and, in domestic cats, is also a mandatory relay for afferents from the principal brainstem auditory nuclei (Aitkin and Phillips, 1984;Goldberg and Moore, 1967). Because neurons of the IC integrate information processed in parallel by the various brainstem auditory pathways, knowledge of the structure and function of the IC is basic to our understanding of the neural processing of sound.The postnatal development of the IC has been studied in a number of eutherian species, particularly the domestic cat (for reviews, see Moore, 1983; Rubel, 19781, and there have been several studies of cytogenesis of the IC in both eutherian (Altman and Bayer, 1981;Cooper and Rakic, 1981;Taber-Pierce, 1973) and metatherian species (Aitkin et al, 1991;Sanderson and Aitkin, 1990). However, aside from the study by Willard and Martin (1986) of multipolar cells of the cochlear nuclei in pouch-young opossum and the early studies of McCrady et al (1937McCrady et al ( , 1940 of the cochlear microphonic potentials in opossums, the development of the cytoarchitecture, connections, and electrical activity in the auditory systems of embryonic mammals has been given little attention, and these features remain to be correlated with one another.…”

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confidence: 99%

The morphological development of the inferior colliculus in a marsupial, the northern quoll (Dasyurus hallucatus)

Aitkin

Nelson

Farrington

et al. 1994

J of Comparative Neurology

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As a part of a project concerning the development of hearing, some features of the morphological development of the inferior colliculus were studied in a marsupial, the Northern quoll or native cat (Dasyurus hallucatus). Marsupials are of particular interest in developmental studies because much embryonic development occurs outside the uterus, in the pouch. Nissl-stained material was prepared from pouch-young at various ages between 11 and 81 days, and for a number of adults. Four pouch-young were injected with tritiated thymidine and killed later during pouch life. The inferior colliculus is first recognizable in pouch-young aged 23 days, when it is bordered by a cell-sparse ring of tissue. By this time, the labelling patterns following injections of tritiated thymidine made on days 7-9 suggest that migration of cells to the inferior colliculus from the ventricular germinal zone has been largely completed. At 81 days, close to the time when the young move out of the pouch, the adult cytoarchitecture--a central nucleus flanked by dorsal and lateral cortical regions--is clear. Cell areas expand monotonically as a function of age. The period of days 45-50 is associated with a large expansion of cell volume and a concomitant decrease in packing density. It is likely that functional connections are forming during this period, which may herald the onset of hearing in the quoll. Total cell numbers increase to a peak at day 36, fall to a minimum at day 50, and rise again to the adult value. The second increase is likely to be a phase of glial proliferation, in part associated with the onset of myelination. This increase correlates with departure of the young from the pouch.

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Neurogenesis in a Marsupial: The Brush-Tailed Possum <i>(Trichosurus vulpecula)</i>

Cited by 19 publications

References 35 publications

Neurogenesis in a Marsupial: The Brush-Tailed Possum <i>(Trichosurus vulpecula)</i>

Neurogenesis in a Marsupial: The Brush-Tailed Possum <i>(Trichosurus vulpecula)</i>

Comparative Views of Adult Neurogenesis

The morphological development of the inferior colliculus in a marsupial, the northern quoll (Dasyurus hallucatus)

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