Neurogenesis in the adult hippocampus: history, regulation, and prospective roles

Fares, Jawad; Diab, Zeina Bou; Nabha, Sanaa; Fares, Youssef

doi:10.1080/00207454.2018.1545771

Cited by 110 publications

(70 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…167 These progenitors initiate neurogenesis, which is the process by which neurons are produced from neural stem cells. 168 These nerve fibers in the tumor microenvironment regulate cancer initiation and dissemination, providing insights into how doublecortin-expressing neurons can be targeted for therapy.…”

Section: Epithelial-mesenchymal Transition: What Is New?mentioning

confidence: 99%

Molecular principles of metastasis: a hallmark of cancer revisited

Fares

Khachfe

et al. 2020

Sig Transduct Target Ther

Self Cite

1,538

935

View full text Add to dashboard Cite

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination process. The invading tumor cell, on its way to the target site, interacts with other proteins and cells. Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and plasticity. Communication with the tumor microenvironment allows invading cancer cells to overcome stromal challenges, settle, and colonize. These characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its microenvironment. Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. In this review, the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.

show abstract

Section: Epithelial-mesenchymal Transition: What Is New?mentioning

confidence: 99%

Molecular principles of metastasis: a hallmark of cancer revisited

Fares

Khachfe

et al. 2020

Sig Transduct Target Ther

Self Cite

1,538

935

View full text Add to dashboard Cite

show abstract

“…In mouse, at the end of the embryonic period some of the RGCs transform into astrocytes (Gaiano et al, 2000;Ventura and Goldman, 2007). The majority of these cells are non-neurogenic, since only RGC-astrocyte-like cells found in discrete regions of the telencephalon, mainly the SVZ of the lateral ventricles and the subgranular zone (SGZ) of the DG of the hippocampus, conserved their neurogenic properties during adulthood (Dennis et al, 2016;Fares et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals

et al. 2020

View full text Add to dashboard Cite

In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in the adult zebrafish and mouse telencephalon share many similarities at the cellular and molecular level. However, upon injury during tissue repair, the situation is entirely different. In zebrafish, inflammation caused by traumatic brain injury or by induced neurodegeneration initiates specific and distinct neurogenic programs that, in combination with signaling pathways implicated in constitutive neurogenesis, quickly, and efficiently overcome the loss of neurons. In the mouse brain, injuryinduced inflammation promotes gliosis leading to glial scar formation and inhibition of regeneration. A better understanding of the regenerative mechanisms occurring in the zebrafish brain could help to develop new therapies to combat the debilitating consequences of brain injury, stroke, and neurodegeneration. The aim of this review is to compare the properties of neural progenitors and the signaling pathways, which control adult neurogenesis and regeneration in the zebrafish and mammalian telencephalon.

show abstract

“…Both signaling pathways are not only important for early normal brain development but also for neurogenesis in the adult brain 47 . mTOR has been suggested to regulate neuronal differentiation and dendritic maturation 48 .…”

Section: Introductionmentioning

confidence: 99%

The stress–Wnt-signaling axis: a hypothesis for attention-deficit hyperactivity disorder and therapy approaches

et al. 2020

View full text Add to dashboard Cite

Attention-deficit hyperactivity disorder (ADHD) is one of the most common psychiatric neurodevelopmental disorders in children and adolescents. Although ADHD has been studied for nearly a century, the cause and pathophysiology of ADHD is yet largely unknown. However, findings from previous studies have resulted in the formation of a new hypothesis: Apart from the well-known multifactorial etiology of ADHD, recent evidence suggests that the interaction between genetic and environmental factors and especially Wnt- and mTOR-signaling pathways might have an important role in the pathophysiology of ADHD. The Wnt-signaling pathway is known to orchestrate cellular proliferation, polarity, and differentiation, and the mTOR pathway is involved in several significant processes of neurodevelopment and synaptic plasticity. As a result, dysregulations of these pathways in a time-dependent manner could lead to neurodevelopmental delays, resulting in ADHD phenotype. This review presents further evidence supporting our hypothesis by combining results from studies on ADHD and Wnt- or mTOR-signaling and the influence of genetics, methylphenidate treatment, Omega-3 supplementation, and stress.

show abstract

Neurogenesis in the adult hippocampus: history, regulation, and prospective roles

Cited by 110 publications

References 165 publications

Molecular principles of metastasis: a hallmark of cancer revisited

Molecular principles of metastasis: a hallmark of cancer revisited

Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals

The stress–Wnt-signaling axis: a hypothesis for attention-deficit hyperactivity disorder and therapy approaches

Contact Info

Product

Resources

About