Neurogenesis in zebrafish

Alunni, Alessandro; Coolen, Marion; Foucher, Isabelle; Bally‐Cuif, Laure

doi:10.1016/b978-0-12-814405-3.00026-6

Cited by 5 publications

(4 citation statements)

References 526 publications

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“…Delta/Notch signaling and HES/Her transcription factors control NSC maintenance and regulate NPC progression in neurogenesis ( Kageyama et al, 2007 ). Their activities differ during primary neurogenesis in the early neuroepithelium of anamniotes, during embryonic brain growth in neural proliferation zones, and in adult neural stem cell niches ( Alunni et al, 2020 ; Kriegstein and Alvarez-Buylla, 2009 ). Here, we analyzed Her activities in the zebrafish TPZ.…”

Section: Discussionmentioning

confidence: 99%

A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone

2023

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Neural proliferation zones mediate brain growth and employ Delta/Notch signaling and HES/Her transcription factors to balance neural stem cell (NSC) maintenance with the generation of progenitors and neurons. We investigated Notch-dependency and function of her genes in the thalamic proliferation zone of zebrafish larvae. Nine Notch-dependent genes, her2, her4.1-4.5, her12, her15.1-15.2, and two Notch-independent genes, her6 and her9, are differentially expressed and define distinct NSC and progenitor populations. her6 prominently executes patterning information to maintain NSCs and the zona limitans intrathalamica Shh signaling activity. Surprisingly, simultaneous deletion of nine Notch-dependent her genes does not affect NSCs or progenitor formation, and her4 overexpression only caused reduction of ascl1b progenitors. Combined genetic manipulations of Notch-dependent and -independent her genes suggest that her6 in the thalamic proliferation zone prominently maintains NSCs and inhibits NSC-to-progenitor lineage transitions. The her gene network is characterized by redundant gene functions, with Notch-independent her genes better substituting for loss of Notch-dependent her genes than vice versa. Together, her gene regulatory feedback loops and cross-regulation contribute to the observed robustness of NSC maintenance.

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Section: Discussionmentioning

confidence: 99%

A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone

2023

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“…Delta/Notch signaling and HES/HER transcription factors play important roles, both in NSC maintenance and control of NPC progression in neurogenesis (Kageyama et al, 2007). HES/HER activities differ during primary neurogenesis in the early neuroepithelium of anamniotes, during embryonic brain growth in neural proliferation zones, and in adult neural stem cell niches (Alunni et al, 2020; Kriegstein and Alvarez-Buylla, 2009). Here, we analyzed Her activities in the zebrafish TPZ, which is highly active in neurogenesis at late embryonic and early larval stages.…”

Section: Discussionmentioning

confidence: 99%

A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone

Sigloch

Spitz

Driever

2022

Preprint

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Neural proliferation zones mediate brain growth, and employ Delta/Notch signaling and HES/HER transcription factors to balance neural stem cell (NSC) maintenance and generation of progenitors and neurons. We investigated Notch-dependency and function of her genes in the thalamic proliferation zone of developing zebrafish larvae. Nine Notch-dependent genes, her2, her4.1-5, her12, her15.1-2, and two Notch-independent genes, her6, her9, are differentially expressed, and define distinct NSC and progenitor populations. her6 prominently executes patterning information to maintain NSCs and the zona limitans intrathalamica Shh signaling activity. her6, her9 double mutants reveal that Notch-independent her genes predominantly regulate NSC maintenance and transition into the progenitor pool. Surprisingly, combined deletion of all Notch-dependent her genes does not affect NSCs or progenitor formation. Combined genetic manipulation of up to eleven Notch-dependent and -independent her genes revealed that Notch-dependent her genes may regulate progenitor progression into neurogenesis, but not progenitor generation itself. The her gene network is partially redundant, with Notch-independent her genes better substituting for loss of Notch-dependent genes than vice versa. Together, her gene regulatory feedback loops and crossregulation contribute to the observed robustness of NSC maintenance.

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“…This implies the need to better understand the balance between the factors comprising the damaged stem cell niche, and the intrinsic regenerative programs of distinct aNSPC populations. With many excellent reviews already published on this topic ( Alunni and Bally-Cuif, 2016 ; Alunni et al, 2020 ), here we strive to provide a brief synopsis of the newest developments in this area to contrast with the regulators of aNSPCs observed under physiological conditions.…”

Section: Cell Intrinsic and Injury-induced Signals Regulate Adult Neu...mentioning

confidence: 99%

“…In the spinal cord, upon injury ependymoglia enter the cell cycle to produce motor neurons for functional swimming recovery ( Reimer et al, 2009 ). In both the forebrain and spinal cord, numerous developmental regulatory pathways, such as Wnt, Notch, Shh, and ID1/BMP, are recapitulated following injury ( Cardozo et al, 2017 ; Alunni et al, 2020 ; Zhang et al, 2021 ). Additionally, studies in the adult forebrain ( Kyritsis et al, 2012 ) and larval spinal cord ( Tsarouchas et al, 2018 ) confirm that activation of the immune response post-injury is critical to induce RGCs to regenerate.…”

Section: Cell Intrinsic and Injury-induced Signals Regulate Adult Neu...mentioning

confidence: 99%

Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators

Caron

Trzuskot

Lindsey

2022

Front. Cell Dev. Biol.

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Adult neural stem and progenitor cells (aNSPCs) persist lifelong in teleost models in diverse stem cell niches of the brain and spinal cord. Fish maintain developmental stem cell populations throughout life, including both neuro-epithelial cells (NECs) and radial-glial cells (RGCs). Within stem cell domains of the brain, RGCs persist in a cycling or quiescent state, whereas NECs continuously divide. Heterogeneous populations of RGCs also sit adjacent the central canal of the spinal cord, showing infrequent proliferative activity under homeostasis. With the rise of the zebrafish (Danio rerio) model to study adult neurogenesis and neuroregeneration in the central nervous system (CNS), it has become evident that aNSPC proliferation is regulated by a wealth of stimuli that may be coupled with biological function. Growing evidence suggests that aNSPCs are sensitive to environmental cues, social interactions, nutrient availability, and neurotrauma for example, and that distinct stem and progenitor cell populations alter their cell cycle activity accordingly. Such stimuli appear to act as triggers to either turn on normally dormant aNSPCs or modulate constitutive rates of niche-specific cell cycle behaviour. Defining the various forms of stimuli that influence RGC and NEC proliferation, and identifying the molecular regulators responsible, will strengthen our understanding of the connection between aNSPC activity and their biological significance. In this review, we aim to bring together the current state of knowledge on aNSPCs from studies investigating the zebrafish CNS, while highlighting emerging cell cycle regulators and outstanding questions that will help to advance this fascinating field of stem cell biology.

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Neurogenesis in zebrafish

Cited by 5 publications

References 526 publications

A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone

A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone

A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone

Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators

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