Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy

Dvck., Peter James; Stevens., John Clarke; O’Brien, Peter C.; Oviatt, Karen F.; Lais, Affred C.; Coventry, Mark B.; Beabout, John W.

doi:10.1212/wnl.33.3.357

Cited by 30 publications

(2 citation statements)

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“…Therefore, the normal functioning of PNS in bone is essential for maintaining skeletal homeostasis and fracture healing [113]. It is reported that patients with insufficient peripheral innervation have delayed fracture healing or nonunion, and suffer from the recurrence of fractures [114–117]. For example, damage to proprioceptive receptors during bone fracture often results in the failure to unite [118].…”

Section: Engineering Innervated Bone Implant Materialsmentioning

confidence: 99%

Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration

et al. 2018

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Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, and play important roles during bone development and fracture healing by supplying oxygen, nutrients, and cells. However, despite the successful development of bone mimetic materials that can replace damaged bone from a structural point of view, most of the available bone biomaterials often do not induce sufficient formation of blood vessels and nerves. In part, this is due to the difficulty of integrating and regulating multiple tissue types within artificial materials, which causes a gap between native skeletal tissue. Therefore, understanding the anatomy and underlying interaction mechanisms of blood vessels and nerve fibers in skeletal tissue is important to develop biomaterials that can recapitulate its complex microenvironment. In this perspective, we highlight the structure and osteogenic functions of the vascular and nervous system in bone, in a coupled manner. In addition, we discuss important design criteria for engineering vascularized, innervated, and neurovascularized bone implant materials, as well as recent advances in the development of such biomaterials. We expect that bone implant materials with neurovascularized networks can more accurately mimic native skeletal tissue and improve the regeneration of bone tissue.

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Section: Engineering Innervated Bone Implant Materialsmentioning

confidence: 99%

Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration

et al. 2018

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“…Experimental sectioning of posterior spinal roots in cats (16,17) and studies of patients with leprosy (18), inherited sensory neuropathies (19), and diabetes (20–22) have shown that sensation loss is a major risk covariate for limb fractures, plantar ulcers, and neurogenic arthropathy (Charcot joints). In diabetes, these complications cause severe morbidity and high health care costs.…”

Section: Primary and Surrogate Measures To Assess Decreased Sensationmentioning

confidence: 99%

Assessing Decreased Sensation and Increased Sensory Phenomena in Diabetic Polyneuropathies

2013

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Loss of sensation and increased sensory phenomena are major expressions of varieties of diabetic polyneuropathies needing improved assessments for clinical and research purposes. We provide a neurobiological explanation for the apparent paradox between decreased sensation and increased sensory phenomena. Strongly endorsed is the use of the 10-g monofilaments for screening of feet to detect sensation loss, with the goal of improving diabetic management and prevention of foot ulcers and neurogenic arthropathy. We describe improved methods to assess for the kind, severity, and distribution of both large- and small-fiber sensory loss and which approaches and techniques may be useful for conducting therapeutic trials. The abnormality of attributes of nerve conduction may be used to validate the dysfunction of large sensory fibers. The abnormality of epidermal nerve fibers/1 mm may be used as a surrogate measure of small-fiber sensory loss but appear not to correlate closely with severity of pain. Increased sensory phenomena are recognized by the characteristic words patients use to describe them and by the severity and persistence of these symptoms. Tests of tactile and thermal hyperalgesia are additional markers of neural hyperactivity that are useful for diagnosis and disease management.

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Genetic heterogeneity in hereditary sensory and autonomic neuropathies: The need for improved ascertainment

Dyck

Schaid

2000

Muscle Nerve

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Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy

Cited by 30 publications

References 0 publications

Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration

Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration

Assessing Decreased Sensation and Increased Sensory Phenomena in Diabetic Polyneuropathies

Genetic heterogeneity in hereditary sensory and autonomic neuropathies: The need for improved ascertainment

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