1970
DOI: 10.3109/00365597009136224
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Neurogenic Bladder Diagnosed Pharmacologically on the Basis of Denervation Supersensitivity

Abstract: A test described by Lapides et al. 1962 for diagnosis of neurogenic bladder, based on denervation supersenisitivity of detrusor to cholinergic stimulation, is critically reviewed. The "localized stretch response of bladder muscle" to instillation of fluid described by these authors seems to be an artifact. In a modified method developed by the author the denervation test consists of a continual reading of the intravesical pressure response to subcutaneous administration of 0.25 mg carbachol (equivalent to 2.5… Show more

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Cited by 78 publications
(21 citation statements)
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“…Bladder smooth muscle hypersensitivity to carbacholine after parasympathetic decentralization is well described (Lapides, Friend, Ajemian, and Reus, 1962;Glahn, 1970). A similar hypersensitivity of the urethra to the a-adrenoceptor stimulating drug ethylphenylephrine was described by Koyanagi and Tsuji (1978).…”
Section: Present Studymentioning
confidence: 67%
See 1 more Smart Citation
“…Bladder smooth muscle hypersensitivity to carbacholine after parasympathetic decentralization is well described (Lapides, Friend, Ajemian, and Reus, 1962;Glahn, 1970). A similar hypersensitivity of the urethra to the a-adrenoceptor stimulating drug ethylphenylephrine was described by Koyanagi and Tsuji (1978).…”
Section: Present Studymentioning
confidence: 67%
“…Detrusor smooth muscle supersensitivity to parasympathomimetics following parasympathetic denervation, or more correctly, decentralization, is well known (Lapides, Friend, Ajemian, and Reus, 1962) and widely used as a test for lesion of the parasympathetic detrusor innervation (Glahn, 1970;111).…”
Section: Chapter V Urethral Denervation Supersensitivitymentioning
confidence: 99%
“…This test turns positive 1-2 weeks after interruption of ner vous pathways. The specificity is high, nearly 100%, if muscular integrity is intact [4], It seems unlikely that local pain played a role in the development of retention, since retention occurred when the eruption had nearly healed.…”
Section: Discussionmentioning
confidence: 99%
“…1). Denervation supersen sitivity test according to Glahn [4] was positive with an increase in intravesical pressure of 31 cm H20 after administration of 0.25 mg carbachol subcutaneously (fig-2).…”
Section: Case Reportmentioning
confidence: 98%
“…Patients suffering from peripheral denervation of the bladder often have an increased sensitivity to parasympathomimetics. Treat ment with such drugs should therefore initially be given in relatively low doses [61]. Theoretically, a-adrenoceptor-blocking agents may improve the parasympathetic activity on the bladder via an effect on the autonomic ganglia [8], but the potential detrusor-stimulating effect of these drugs is still not clarified.…”
Section: Drugs Stimulating Detrusor Contractilitymentioning
confidence: 99%