Neurogenic Inflammation in Nasal Allergy: Histochemical and Pharmacological Studies in Guinea Pigs: A review

Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H1-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat

“…In the present study, intranasal application of TDI induced repeated sneezes and pre-treatment with chlorpheniramine significantly reduced TDI-induced sneezes in TDI-sensitized rats. These findings are in line with our previous findings (2,3) and indicate that the release of histamine in the nasal mucosa of sensitized animals is induced by TDI provocation through neurogenic inflammation (2) and that antihistamine plays an inhibitory role on TDI-induced nasal hypersensitivity symptoms by blocking H1R. However, the suppression of the up-regulation of H1R by chlorpheniramine was found to be partial (Fig.…”

Inflammation-Induced Plasticity of the Afferent Innervation of the Airways

“…In sensitized guinea pigs, challenge of the nasal mucosa with the sensitizing allergen enhanced the synthesis of substance P and CGRP in the cell bodies of trigeminal ganglion neurons and the axonal transportation of these peptides to their terminals in the nasal mucosa (56). Similarly, within 24 hr of allergen inhalation, there is a 3-to 5-fold elevation in the amount of substance P, NK-A and CGRP immunoreactivity in the lungs of guinea pigs (17).…”

Guinea Pig Histamine N-Methyltransferase: cDNA Cloning and mRNA Distribution

“…The rat kidney HMT cDNA was cloned (3), followed by the human counterpart (4,5). Guinea pigs have been used as an in vivo and in vitro model for pharmacological analysis of the histaminergic system, especially for studies on allergic reactions (6,7). The primary structure of its HMT protein and its genetic structure will be useful comparing the histaminergic system in this animal with those of other mammals, including humans.…”