Neurogenic Mucous Colitis

Bockus, Henry L.; Bank, Joseph; Wilkinson, Shelley A.

doi:10.1097/00000441-192812000-00006

Cited by 79 publications

(26 citation statements)

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“…IBS is characterized by abdominal pain or discomfort combined with alterations in bowel function. As early as 1928, it was hypothesized that dysfunction of the autonomic nervous system contributed to the symptoms seen in IBS (Bockus et al, 1928). The sympathetic and parasympathetic branches of the autonomic nervous system mediate central nervous system communication with the gut, largely through modulation of the third autonomic nervous system branch, the enteric nervous system.…”

Section: Modulation Of the Autonomic Nervous System And Patients' Resmentioning

confidence: 99%

“…It has been suggested that the autonomic nervous system can modulate visceral sensitivity and that the central nervous system can influence the motility and secretory activity of the GI tract by way of autonomic pathways via the enteric nervous system (Iovino et al, 1995;Vandler et al, 1998). It has also been suggested that subtle abnormalities in the autonomic nervous system are an underlying factor in the symptoms reported by patients with functional GI disorders (Bockus et al, 1928;Bharucha et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Pathophysiology underlying irritable bowel syndrome -From the viewpoint of dysfunction of autonomic nervous system activity-

Manabe

Tanaka

Hata

et al. 2009

J. Smooth Muscle Res.

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Although irritable bowel syndrome (IBS) is the most common gastrointestinal disease and is found in up to 50% of patients referred to gastroenterologists, its pathogenesis remains unexplained. Lately most attention has been focused on visceral hypersensitivity related to dysfunction of the autonomic nervous system. Although there have been many reports regarding the autonomic nervous system in IBS patients, the results have not always been consistent. In many studies, increased sympathetic nervous system activity and decreased parasympathetic nervous system activity have been the most frequently noted differences when IBS patients are compared with healthy controls. There are also some differences among IBS symptom subgroups and some differences between men and women. Data from previous studies have been inconsistent, with complicating factors resulting in difficulties in classification and the possibility of multiple physiological pathways for a similar symptom picture. Further studies based on the Rome III criteria are required to evaluate whether or not autonomic functions significantly differ from each other. However, although there are many methods of measurement for evaluation of the autonomic nervous system, there are few of these methods that are not only accurate but also cost-effective, non-invasive, and easy to perform. Recently, we developed a new method with the abovementioned advantages for measuring fingertip blood flow in evaluating the autonomic nervous system by continuous-wave Doppler sonography. Using this method, we found that abnormal fingertip blood flow responses suggested the presence of excess sympathetic activity.

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Section: Modulation Of the Autonomic Nervous System And Patients' Resmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pathophysiology underlying irritable bowel syndrome -From the viewpoint of dysfunction of autonomic nervous system activity-

Manabe

Tanaka

Hata

et al. 2009

J. Smooth Muscle Res.

View full text Add to dashboard Cite

show abstract

“…Besterman et al (1981) measured gastrointestinal hormones during fasting and postprandial phase in IBS patients, and they concluded that the levels of pancreatic polypeptide and neurotensin showed slight but significant difference between IBS patients and controls. On the other hand, relationship between psychological stress and onset or exacerbation of symptoms of IBS has been reported by many authors (Bockus et al 1928;Chaudhary and Truelove 1962). Drossman et al (1982) mentioned that IBS patients had a tendency to complain frequently that the stress changed their bowel patterns and produced abdominal pain.…”

mentioning

confidence: 89%

Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.

Fukudo

Suzuki

1987

Tohoku J. Exp. Med.

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“…1 In 1928, Bockus and his colleagues described the syndrome as "neurogenic mucous colitis." 2 Bockus determined that this disease can only be diagnosed by exclusion which was the belief until the 1970's.…”

Section: Brief Historymentioning

confidence: 99%