Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review

Abstract

Neuroglialchoristoma is a rare cerebral heterotopia typically involving extracranial midline structures of the head and neck, including the nose, nasopharynx and oral cavity. It rarely involves non-midline structures, such as the middle ear, mastoid and orbit. We report the case of a 63-year-old woman with right-sided hearing loss and aural fullness who was diagnosed with neuroglialchoristoma of the middle ear and mastoid. To our knowledge, this is the first report on neuroglialchoristomawith massive tympanosclerosis. The presence of combination supported the inhalation theory of neuroglialchoristoma, given that tympanosclerosis is typically caused by Eustachian tube dysfunction.

Congenital neuroglial choristoma of the foot

“…Alternatively, an error of early embryonic development may result in displaced neuroectodermal cells which undergo differentiation and ectopic proliferation [3]. Previously described cases typically have been in the midline head and neck, though cases have been reported in the thoracolumbar soft tissues and lungs [4], [5], [6], [7]. To our knowledge, there have been no prior published cases of a neuroglial choristoma in an extremity.…”

Glia-Choristom – Ein seltener Befund im Mittelohr

“…B. in der Nase oder Epipharynx [3]. Im Mittelohr sind Glia-Choristome eine Seltenheit, bisher wurden nur 33 Fälle beschrieben [4].…”

Ear and Temporal Bone Pathology: Neural, Sclerosing and Myofibroblastic Lesions

“…A similar lesion to encephalocele, in which a connection to the normal brain tissue is not demonstrated, is designated "neuroglial heterotopia" or "neuroglial choristoma", catchall terms for benign mature ectopic brain tissue with no connection to the brain or spinal cord [21]. The exact pathogenesis of neuroglial heterotopia is unclear; some postulate that it represented a prior encephalocele, in which the connection has been resorbed [20].…”