Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention

Sloan, Emily A.; Sampognaro, Paul J.; Junn, Jacqueline C.; Chin, Cynthia T.; Jacques, Line; Ramachandran, Prashanth; DeRisi, Joseph L.; Wilson, Michael R.; Kriegstein, Arnold R.; Bollen, Andrew W.; Solomon, David A.; Margeta, Marta; Engstrom, John W.

doi:10.1007/s00401-019-02089-7

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Unregulated stem cell clinics around the world pose an ongoing threat to unsuspecting patients and the field alike. Lapses in quality control can replace hopes in stem cell therapies with dismay when tumors113 or hypertrophic inflammatory tumor-like lesions are identified 114…”

Section: The Ethical Bar Of Safety For Translation Of Neuroregenerative Therapiesmentioning

confidence: 99%

Regenerative medicine for neurological diseases—will regenerative neurosurgery deliver?

Burns¹,

Quiñones‐Hinojosa

2021

BMJ

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Regenerative medicine aspires to transform the future practice of medicine by providing curative, rather than palliative, treatments. Healing the central nervous system (CNS) remains among regenerative medicine’s most highly prized but formidable challenges. “Regenerative neurosurgery” provides access to the CNS or its surrounding structures to preserve or restore neurological function. Pioneering efforts over the past three decades have introduced cells, neurotrophins, and genes with putative regenerative capacity into the CNS to combat neurodegenerative, ischemic, and traumatic diseases. In this review we critically evaluate the rationale, paradigms, and translational progress of regenerative neurosurgery, harnessing access to the CNS to protect, rejuvenate, or replace cell types otherwise irreversibly compromised by neurological disease. We discuss the evidence surrounding fetal, somatic, and pluripotent stem cell derived implants to replace endogenous neuronal and glial cell types and provide trophic support. Neurotrophin based strategies via infusions and gene therapy highlight the motivation to preserve neuronal circuits, the complex fidelity of which cannot be readily recreated. We specifically highlight ongoing translational efforts in Parkinson’s disease, amyotrophic lateral sclerosis, stroke, and spinal cord injury, using these to illustrate the principles, challenges, and opportunities of regenerative neurosurgery. Risks of associated procedures and novel neurosurgical trials are discussed, together with the ethical challenges they pose. After decades of efforts to develop and refine necessary tools and methodologies, regenerative neurosurgery is well positioned to advance treatments for refractory neurological diseases. Strategic multidisciplinary efforts will be critical to harness complementary technologies and maximize mechanistic feedback, accelerating iterative progress toward cures for neurological diseases.

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Section: The Ethical Bar Of Safety For Translation Of Neuroregenerative Therapiesmentioning

confidence: 99%

Regenerative medicine for neurological diseases—will regenerative neurosurgery deliver?

Burns¹,

Quiñones‐Hinojosa

2021

BMJ

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Inflammatory pseudotumour presenting as a cervical extradural mass in a 1‐year‐old Bernese Mountain dog

Castro Carnes,

Gutierrez‐Quintana,

Marchesi

et al. 2024

Vet Record Case Reports

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A 1‐year‐old, male, neutered Bernese Mountain dog presented with a 2‐week history of acute‐onset progressive signs of right C6–T2 myelopathy and neck pain. Magnetic resonance imaging of the cervical vertebral column revealed a right‐sided extradural mass at the level of the C6 vertebra causing severe spinal cord compression. A right C5–C7 modified dorsal laminectomy was performed to remove the mass, resulting in its complete excision, except for residual tissue attachments to the ligamentum flavum. Successful spinal cord decompression was achieved, as confirmed by postoperative magnetic resonance imaging. Histopathology and immunochemistry showed a proliferative lesion dominated by a mixture of spindle and histiocytic cells, with associated infiltrates of T‐lymphocytes, B‐lymphocytes and plasma cells suggestive of an inflammatory pseudotumour. Subsequently, the dog underwent a 2‐month course of prednisolone treatment and showed complete recovery. At the 2‐year follow‐up, the dog was neurologically normal.

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Top Ten Discoveries of the Year: Neuromuscular Disease

Margeta

2020

Free Neuropathology

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Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention

Cited by 3 publications

References 16 publications

Regenerative medicine for neurological diseases—will regenerative neurosurgery deliver?

Regenerative medicine for neurological diseases—will regenerative neurosurgery deliver?

Inflammatory pseudotumour presenting as a cervical extradural mass in a 1‐year‐old Bernese Mountain dog

Top Ten Discoveries of the Year: Neuromuscular Disease

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