Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor

Resnik-Docampo, Martin; Cunningham, Kathleen M.; Ruvalcaba, S. Mateo; Choi, Charles; Sauer, Vivien; Jones, D. Leanne

doi:10.1016/j.stemcr.2021.04.006

Cited by 9 publications

(4 citation statements)

References 78 publications

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“…NCAM and L1-CAM are homophilic cell adhesion proteins of the immunoglobulin superfamily (IgCAMs) that couple highly specific cell recognition and adhesion with the control of Receptor Tyrosine Kinase (RTK) signaling [ 6 – 9 ]. NCAM- and L1-CAM-type proteins play key roles during normal development and cancer progression [ 9 – 11 ]. Interestingly, their normal function in signaling can be dissociated from their role in cell adhesion [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila

et al. 2022

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How cell to cell interactions control local tissue growth to attain a species-specific organ size is a central question in developmental biology. The Drosophila Neural Cell Adhesion Molecule, Fasciclin 2, is expressed during the development of neural and epithelial organs. Fasciclin 2 is a homophilic-interaction protein that shows moderate levels of expression in the proliferating epithelia and high levels in the differentiating non-proliferative cells of imaginal discs. Genetic interactions and mosaic analyses reveal a cell autonomous requirement of Fasciclin 2 to promote cell proliferation in imaginal discs. This function is mediated by the EGFR, and indirectly involves the JNK and Hippo signaling pathways. We further show that Fasciclin 2 physically interacts with EGFR and that, in turn, EGFR activity promotes the cell autonomous expression of Fasciclin 2 during imaginal disc growth. We propose that this auto-stimulatory loop between EGFR and Fasciclin 2 is at the core of a cell to cell interaction mechanism that controls the amount of intercalary growth in imaginal discs.

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Section: Introductionmentioning

confidence: 99%

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila

et al. 2022

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“…The IgSF is the largest glycoprotein family with more than 700 gene members in the human genome, in which antibodies are the most well-known members that function as immune recognition molecules with high affinity and specificity to foreigners ( 37 ). Although no antibodies have been discovered in invertebrates ( 3 ), several IgSF members have been identified as cell adhesion molecules, such as fasciclin, neuroglian and Down syndrome cell adhesion molecule (Dscam), during the development of the insect nervous system instead of being involved in immune responses ( 38 – 40 ). Since it is known that IgSF existed prior to the evolutionary divergence of vertebrates and invertebrates, evolutionarily speaking, it remains possible that some proteins from IgSF could have an antibody-like role in immune surveillance in invertebrates.…”

Section: Discussionmentioning

confidence: 99%

A Versatile Hemolin With Pattern Recognitional Contributions to the Humoral Immune Responses of the Chinese Oak Silkworm Antheraea pernyi

Zhou

Cai

et al. 2022

Front. Immunol.

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Hemolin is a distinctive immunoglobulin superfamily member involved in invertebrate immune events. Although it is believed that hemolin regulates hemocyte phagocytosis and microbial agglutination in insects, little is known about its contribution to the humoral immune system. In the present study, we focused on hemolin in Antheraea pernyi (Ap-hemolin) by studying its pattern recognition property and humoral immune functions. Tissue distribution analysis demonstrated the mRNA level of Ap-hemolin was extremely immune-inducible in different tissues. The results of western blotting and biolayer interferometry showed recombinant Ap-hemolin bound to various microbes and pathogen-associated molecular patterns. In further immune functional studies, it was detected that knockdown of hemolin regulated the expression level of antimicrobial peptide genes and decreased prophenoloxidase activation in the A. pernyi hemolymph stimulated by microbial invaders. Together, these data suggest that hemolin is a multifunctional pattern recognition receptor that plays critical roles in the humoral immune responses of A. pernyi.

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“…Other morphogenetic defects include diminished and deformed salivary glands, head involution and dorsal closure defects. SJ proteins also regulate the rate of division of intestinal stem cells [22,23], as well as hemocyte lineage differentiation via interactions with the Hippo pathway [24,25]. Another intriguing feature is the confirmation of the role of SJ components in wound healing [26].…”

Section: Introductionmentioning

confidence: 99%

ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism sensing paracellular diffusion barrier alteration inDrosophilaepithelial cells

de Bournonville,

Jaglarz,

Durel

et al. 2023

Preprint

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Barrier functions of proliferative epithelia are constantly challenged by mechanical and chemical constraints. How epithelia respond to and cope with disturbances of the paracellular diffusion barrier to allow tissue integrity maintenance has been poorly characterized. Cellular junctions play an important role in this process and intracellular traffic contribute to their homeostasis. Here, we reveal that, in Drosophila pupal notum, alteration of the bi- or tricellular septate junctions (SJs) triggers a mechanism with two prominent outcomes. On one hand, there is an increase in the levels of E-cadherin, F-Actin and non-muscle myosin II in the plane of adherens junctions. On the other hand, β-integrin/Vinculin-positive cell contacts are reinforced along the lateral and basal membranes. We report that the weakening of SJ integrity, caused by the depletion of bi- or tricellular SJ components, reduces ESCRT-III/Vps32/Shrub-dependent degradation and promotes instead Retromer-dependent recycling of SJ components. The consequence of the reduction in Shrub-dependent degradation extends to other transmembrane protein cargoes. Consequently, this trigger increased levels of β-integrin, Crumbs and the Crumbs effectors β-Heavy Spectrin Karst. We propose a mechanism by which epithelial cells, upon sensing alterations in the paracellular diffusion barrier, target Shrub to adjust the degradation/recycling balance and thereby compensate for barrier defects while maintaining epithelial integrity.

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Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor

Cited by 9 publications

References 78 publications

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila

A Versatile Hemolin With Pattern Recognitional Contributions to the Humoral Immune Responses of the Chinese Oak Silkworm Antheraea pernyi

ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism sensing paracellular diffusion barrier alteration inDrosophilaepithelial cells

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