Neuroglobin is up‐regulated in the cerebellum of pups exposed to maternal epileptic seizures

Lima, Daiana Correia; Cossa, Ana Carolina; Perosa, Sandra Regina; Oliveira, Elaine Menezes de; Silva, José António Pereira da; Fernandes, Maria José da Silva; Silva, Iara Ribeiro da; Higa, Elisa Mieko Suemitsu; Naffah-Mazzacoratti, Maria da Graça; Cavalheiro, Ésper A.; Amado, Débora

doi:10.1016/j.ijdevneu.2011.07.002

Cited by 11 publications

(6 citation statements)

References 80 publications

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“…Elevating the neuronal Ngb prior to H 2 O 2 insult enhances neuronal viability by decreasing oxidative stress and increasing intracellular adenosine triphosphate (ATP) concentration (Antao et al, 2010). Ngb expression can be up-regulated in the cerebellum of rat pups exposed to maternal epileptic seizures, implying that Ngb may also be protective against seizures (Lima et al, 2011).…”

Section: Mechanisms Of Ngb Functionmentioning

confidence: 99%

Brain globins in physiology and pathology

Xie

Yang

2016

Med Gas Res

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Globins are globular proteins for either transport or storage of oxygen which are critical for cellular metabolism. Four globins have been identified in rodent and human brains. Among them, neuroglobin, cytoglobin and hemoglobin chains are constitutively expressed in normal brain, while myoglobin is only expressed in some neurological disorders. Studies on the molecular structure, expression and functional features of these brain globins indicated that they may play crucial roles in maintenance of neural cell survival and activity, including neurons and astrocytes. Their regulation in neurological disorders may help thoroughly understand initiation and progression of ischemia, Alzheimer's disease and glioma, etc. Elucidation of the brain globin functions might remarkably improve medical strategies that sustain neurological homeostasis and treat neurological diseases. Here the expression pattern and functions of brain globins and their involvement in neurological disorders are reviewed.

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Section: Mechanisms Of Ngb Functionmentioning

confidence: 99%

Brain globins in physiology and pathology

Xie

Yang

2016

Med Gas Res

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“…It is also possible to compare vehicle- and AED-treated groups under better controlled environmental conditions if laboratory animals are used. Recent studies of this kind are elucidating many effects of uncontrolled seizures during pregnancy in female laboratory rats; to date, there is both evidence for and against adverse effects of seizures during pregnancy on development of the offspring [42–45]. …”

Section: In Utero Exposure Of the Fetus To Aedsmentioning

confidence: 99%

Impact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research

Bath

Scharfman

2013

Epilepsy & Behavior

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Epilepsy affects approximately 1% of children under the age of 15, making it a very common neurological disorder in the pediatric population (Russ et al., 2012 [1]). In addition, ∼0.4–0.8% of all pregnant women have some form of epilepsy (Hauser et al., 1996a,b; Borthen et al., 2009; Krishnamurthy, 2012 [2–5]). Despite the potential deleterious effects of antiepileptic drugs (AEDs) on the developing brain, their use is still required for seizure control in pregnant women (Krishnamurthy, 2012 [5]), and they represent the standard approach for treating children with epilepsy (Chu-Shore and Thiele, 2010; Quach et al., 2010; Verrotti et al., 2011 [6–8]). Even when AEDs are effective, there are potential side effects, including cognitive and affective changes or altered sleep and appetite. The consequences of AED exposure in development have been studied extensively (Canger et al., 1999; Modi et al., 2011a,b; Oguni, 2011 [9–12]). Despite intensive study, there is still debate about the long-term consequences of early life AED exposure. Here, we consider the evidence to date that AED exposure, either prenatally or in early postnatal life, has significant adverse effects on the developing brain and incorporate studies of laboratory animals as well as those of patients. We also note the areas of research where greater clarity seems critical in order to make significant advances. A greater understanding of the impact of AEDs on somatic, cognitive and behavioral development has substantial value because it has the potential to inform clinical practice and guide studies aimed at understanding the genetic and molecular bases of comorbid pathologies associated with common treatment regimens. Understanding these effects has the potential to lead to AEDs with fewer side effects. Such advances would expand treatment options, diminish the risk associated with AED exposure in susceptible populations, and improve the quality of life and health outcomes of children with epilepsy and children born to women who took AEDs during pregnancy.

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“…One example is that Ngb overexpression was protective against beta-amyloid and NMDA toxicity in both cultured neurons and in the Alzheimer’s disease (AD) model of mice [7,28]. Additionally, Ngb expression can be up-regulated in the cerebellum of rat pups exposed to maternal epileptic seizures, implying that Ngb may also be protective against seizures [29]. Our recent study showed that Ngb overexpression protects retinal ganglion cells (RGC) against ocular hypertension and glaucomatous damage [30].…”

Section: Neuroprotective Effects Of Ngb Against Neurodegenerative mentioning

confidence: 99%

“…Ngb is also up-regulated in the cerebellum of mouse pups in response to hypoxic-ischemic insults caused by maternal seizures during intrauterine life [29]. These data imply that Ngb up-regulation could be an endogenous compensatory or protective mechanism in response to the sublethal hypoxic/ischemic insults to brain neurons.…”

Section: Tissue Specific Expression Of Ngb Gene and Its Regulationmentioning

confidence: 99%

Neuroglobin, a Novel Target for Endogenous Neuroprotection against Stroke and Neurodegenerative Disorders

Liu

et al. 2012

IJMS

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Brain neurons and tissues respond to sublethal injury by activating endogenous protective pathways. Recently, following the failure of a large number of clinical trials for protective strategies against stroke that aim to inhibit a specific ischemia response pathway, endogenous neuroprotection has emerged as a more promising and hopeful strategy for development of therapeutics against stroke and neurodegenerative disorders. Neuroglobin (Ngb) is an oxygen-binding globin protein that is highly and specifically expressed in brain neurons. Accumulating evidence have clearly demonstrated that Ngb is an endogenous neuroprotective molecule against hypoxic/ischemic and oxidative stress-related insults in cultured neurons and animals, as well as neurodegenerative disorders such as Alzheimer’s disease, thus any pharmacological strategy that can up-regulate endogenous Ngb expression may lead to novel therapeutics against these brain disorders. In this review, we summarize recent studies about the biological function, regulation of gene expression, and neuroprotective mechanisms of Ngb. Furthermore, strategies for identification of chemical compounds that can up-regulate endogenous Ngb expression for neuroprotection against stroke and neurodegenerative disorders are discussed.

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Neuroglobin is up‐regulated in the cerebellum of pups exposed to maternal epileptic seizures

Cited by 11 publications

References 80 publications

Brain globins in physiology and pathology

Brain globins in physiology and pathology

Impact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research

Neuroglobin, a Novel Target for Endogenous Neuroprotection against Stroke and Neurodegenerative Disorders

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