Neuroheptapeptide influence on attention and memory in man

Miller, Lyle H.; Harris, Louis C.; Riezen, H. van; Kastin, Abba J.

doi:10.1016/0091-3057(76)90323-3

Cited by 70 publications

(26 citation statements)

References 20 publications

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“…The heightened visuospatial activity observed in this study is comparable to the enhanced selective attention and stimulus processing with visual learning procedure shown in subjects treated with α-MSH and ACTH. [12][13][14][15][16][17] We also found that delayed memory score was less impaired in subjects with red compared to non-red hair. This finding is also consistent with the previous results 16 showing heightened attention and subsequent facilitation of visual discrimination in subjects receiving α-MSH and ACTH.…”

Section: Discussionsupporting

confidence: 54%

“…14 Human subjects, when treated with these peptides, performed significantly better than control subjects in visual memory, digit-symbol substitution test (i.e., visual-motor learning), and continuous performance task. 15 Sandman et al 16 reported that, although the peptides actually raised perceptual threshold of stimuli, once these stimuli were perceived, visual discrimination was significantly facilitated. Thus, it has been postulated that ACTH/α-MSH exert their predominant effect on attention rather than memory processes (attentional hypothesis).…”

Section: Discussionmentioning

confidence: 99%

“…The subtest score was converted by z-score transformation. An index score for a domain was obtained by transforming the sum of subtest z-scores to a scale with a mean (SD) of 100 (15). The total scale of index scores (i.e., global assessment of cognitive function) was obtained similarly by transforming the sum of index scores that contribute to the total composite to a scale with a mean ± SD, of 100 ± 15 (40-160).…”

Section: Measurementsmentioning

confidence: 99%

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Midazolam causes less sedation in volunteers with red hair

Chua

Tsueda

Doufas

2004

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : We studied sedation, cognition, and mood during midazolam infusion in volunteers with red and non-red (blond or brown) hair, to test the hypothesis that patients with red hair may require more drugs to attain desired levels of sedation.M Me et th ho od ds s: : Twenty red and 19 non-red hair subjects were studied in a randomized, placebo-controlled cross-over design. Subjects were studied during placebo and midazolam at 30 ng·mL -1 target effect site concentration. Sedation was assessed using the observer's assessment of alertness/sedation (OAA/S) scale, the drowsiness visual analogue scale (VAS), and the bispectral index; cognition was assessed using the Repeatable Battery for Assessment of Neuropsychological Status; and mood was assessed using the bipolar form of the Profile of Mood States (POMS).R Re es su ul lt ts s: : Red hair volunteers showed significantly higher OAA/S (P < 0.01) and lower drowsiness VAS (P < 0.05) scores compared to non-red hair subjects during midazolam infusion. Visuospatial score was significantly higher in subjects with red compared to nonred hair during placebo and midazolam trials. Delayed memory score was significantly higher during midazolam infusion in subjects with red compared to non-red hair. There were no group differences in POMS during either trials.C Co on nc cl lu us si io on n: : Midazolam appears to cause significantly less sedation and cognitive impairment in red haired subjects. Objectif : Étudier la sédation, la fonction cognitive et l'humeur pendant une perfusion de midazolam chez des volontaires aux cheveux roux et non roux (blonds ou châtains) pour tester l'hypothèse voulant que chez les patients aux cheveux roux, il faut de plus grandes quantités de médicaments pour obtenir les niveaux de sédation désirés. Méthode Conclusion : Le midazolam semble causer moins de sédation et d'altération de la fonction cognitive chez les sujets aux cheveux roux.NECDOTAL descriptions exist that subjects with red hair may faint easily and are difficult to anesthetize. 1 A mail survey of anesthesiologists A has shown that redhaired patients are perceived to have a propensity for drug hypersensitivity, airway difficulties, hemodynamic instability, dysrrhythmias, combativeness and confusion at anesthesia emergence, nausea/vomiting, and bleeding. Our clinical observations suggest that patients with red hair may also require more drugs to attain desired levels of sedation.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Midazolam causes less sedation in volunteers with red hair

Chua

Tsueda

Doufas

2004

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

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“…However, the peptide-induced enhancement of P4 and P5 waves in the somatosensory EPs and of N100 and P300 waves in the frontal and parietal acoustic EPs was found only in a simple stimulus-response situation. In the two-stimulus test situation which required perhaps even a higher degree of attention and vigilance, ACTH,10 increased the latency and decreased the amplitude of the principal (negative and positive) late components (Miller et al, 1976), and ACTH4. 9 suppressed the P300 wave (Fehm-Wolfsdorf, 1981).…”

Section: Effects Of Acth/msh Peptides On Macroelectrophysiological Mementioning

confidence: 99%

“…Miller et al (1976) presented irrelevant and relevant visual stimuli to their subjects. The subjects were asked to press a button only on appearance of the relevant stimulus.…”

Section: Effects Of Acth/msh Peptides On Macroelectrophysiological Mementioning

confidence: 99%