2020
DOI: 10.3390/cells9112521
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Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension

Abstract: The autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and updated evidence of potential therapies targeting both systems in this condition, particularly in Groups 1 and 2. State of the art knowledge in preclinical and clinical use of pharmacologic drugs (beta-blockers, beta-three adrenoceptor agonists, or renin-angiotensin… Show more

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Cited by 7 publications
(6 citation statements)
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“…52 The autonomic nervous system is also involved in the pathogenesis of PAH, suggesting that this neurohormonal system can be regulated to treat PAH. 53 Besides CD248, there are other potential therapeutic targets for PAH such as miRNAs and spermidine. MiRNAs are non-coding singlestranded RNAs of approximately 22 nucleotides in length.…”
Section: Targeted Therapies For Pulmonary Arterial Hypertension (Pah)mentioning
confidence: 99%
“…52 The autonomic nervous system is also involved in the pathogenesis of PAH, suggesting that this neurohormonal system can be regulated to treat PAH. 53 Besides CD248, there are other potential therapeutic targets for PAH such as miRNAs and spermidine. MiRNAs are non-coding singlestranded RNAs of approximately 22 nucleotides in length.…”
Section: Targeted Therapies For Pulmonary Arterial Hypertension (Pah)mentioning
confidence: 99%
“…PA denervation (PADN) targets directly the sympathetic stimulus over the pulmonary vasculature and has emerged as a promising therapeutical option for PH. During the past decade, multiple studies have been published both in the experimental field and clinical arena with controversial results (for an extensive review see a dedicated paper 124 ). Overall, a beneficial effect with PADN has been observed in experimental models of acute PH 125,126 and chronic PH induced by monocrotaline [127][128][129] , and also in patients with PAH.…”
Section: Pulmonary Arterial Denervationmentioning
confidence: 99%
“…Therefore, many pharmacological and non-pharmacological interventions on the neurohormonal system have been investigated in preclinical and few clinical studies [8]. Nevertheless, translation from preclinical to clinical studies is difficult and is often lacking.…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, translation from preclinical to clinical studies is difficult and is often lacking. Two recent reviews extensively described molecular pathways underlying the detrimental effects of neurohormonal activation [9] and pharmacological or invasive strategies targeting the neurohormonal system in PAH [8]. We wish to extend on this topic, and thereby provide future directions for research into the neurohormonal system in PAH.…”
Section: Introductionmentioning
confidence: 99%