Neurohormones in Vasovagal Syncope: Are They Important?

Williford, Noah N.; Chapleau, Mark W.; Olshansky, Brian

doi:10.1161/jaha.119.013129

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…The association between psychological distress and VVS may indicate a common pathophysiological pathway, there are multiple neurotransmitters have been shown to be associated with VVS, but serotonin was among the most studied ones [ 20 ]. Some serotonin receptors in the central nervous system (CNS) have shown to be associated with blood pressure control, which indicates a clear role of serotonin in blood pressure changes observed in patients with syncope during tilt-table testing [ 21 ].…”

Section: Reviewmentioning

confidence: 99%

Anxiety and Depression as Risk Factors for Vasovagal Syncope and Potential Treatment Targets: A Systematic Review

Abuzainah¹,

Gutlapalli²,

Chaudhuri³

et al. 2022

Cureus

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Vasovagal syncope (VVS) is a transient, sudden loss of consciousness followed by complete resolution, usually due to a paradoxical autonomic reaction that results in hypotension and/or bradycardia. In this study, we assessed the correlation between VVS and a patient's psychiatric status, as well as if this association could be a target in the treatment of those patients. We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched the available literature using the following databases: PubMed, Google Scholar, and ScienceDirect, with last access on July 21, 2022. The search resulted in 1691 articles, and inclusion and exclusion criteria were applied to nine remaining articles, all of which were accepted after using the quality assessment tools, four observational and four randomized controlled trials (RCTs). Four of the included studies assessed the correlation among vasovagal syncope, psychosocial impairment, and quality of life. We found a consistent correlation among VVS, psychosocial impairment, and quality of life (QoL), meaning that VVS patients usually have some degree of psychosocial impairment, especially in the form of anxiety and depression, and a poorer QoL in comparison to their healthy counterparts. The use of psychotherapy and antidepressants was proven to be effective in VVS in RCTs, but further evidence is needed.

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Section: Reviewmentioning

confidence: 99%

Anxiety and Depression as Risk Factors for Vasovagal Syncope and Potential Treatment Targets: A Systematic Review

Abuzainah¹,

Gutlapalli²,

Chaudhuri³

et al. 2022

Cureus

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“…A compelling evidence that plasma levels of epinephrine and vasopressin increase early during HUTT and predict later decreases in blood pressure and syncope is found. Baseline and orthostatic levels of adrenomedullin, endothelin-1, and atrial natriuretic peptide, or their stable metabolites, have also been linked with susceptibility to VVS ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children

Chang,

Peng,

Liu

et al. 2023

Front. Pediatr.

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BackgroundOrthostatic intolerance (OI) is usually mediated by the autonomic nerve and most often happens in the upright position. However, it can also occur in other positions and can be relieved by lying down while likely to have another attack after relief. In the current study, we aim to evaluate the predictive effect of catecholamines and electrolytes on the recurrence of OI in children.Materials and methodsChildren who were diagnosed with vasovagal syncope (VVS), postural tachycardia syndrome (POTS), and VVS combined with POTS were enrolled in this retrospective study and were followed up after 1-year physical treatment. Catecholamines in urine collected within 24 h, renin, angiotensin II, aldosterone in plasma, and electrolytes in both blood and urine collected in the morning were tested. A multivariate analysis and a receiver operating characteristic curve were used to validate the prediction effect.ResultsIn the VVS cohort, the 24 h urine adrenaline (AD) and norepinephrine (NE) levels of the non-recurrence group were lower than the 24 h urine AD and NE levels of the recurrence group, with a significant difference of P < 0.05. A different content can also be witnessed in the POTS cohort that the urine of the non-recurrence group contained lower sodium and chlorine. As for the VVS + POTS cohort, the non-recurrence group has lower AD and NE levels and higher potassium and phosphorus levels in urine, the difference of which proved prominent as well.ConclusionThe study provides further evidence that AD, NE, and electrolytes in urine are promising factors that are closely related to the recurrence of OI in children. The integrated evaluation system merging AD and NE may have better predictive ability.

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The Role of Adenosine and Its Degradation Enzymes – Adenosinedeaminase and Adenosinekinase in Pathogenesis of Vasovagal Syncope

Lazurova

Mitro²,

Popovnakova³

2022

European Journal of Internal Medicine

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Neurohormones in Vasovagal Syncope: Are They Important?

Abstract: See Article Torabi et al

Cited by 4 publications

References 20 publications

Anxiety and Depression as Risk Factors for Vasovagal Syncope and Potential Treatment Targets: A Systematic Review

Anxiety and Depression as Risk Factors for Vasovagal Syncope and Potential Treatment Targets: A Systematic Review

Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children

The Role of Adenosine and Its Degradation Enzymes – Adenosinedeaminase and Adenosinekinase in Pathogenesis of Vasovagal Syncope

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