Neuroimaging and clinical characteristics of brain metastases from esophageal carcinoma in Chinese patients

Feng, Wei; Zhang, Peng; Xiao, Zheng; Shan, Guihua; Chen, Ming; Mao, Weimin

doi:10.4103/0973-1482.151536

Cited by 10 publications

(13 citation statements)

References 26 publications

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“…In previous years, most BMEC reports came from the United States and Japan, whereas fewer reports have come from China, where more cases of this disease have been found [17] but where the investigation has been focused on the diagnosis and treatment of BMEC [18] . The United States was the first to attach great importance to BMEC; this emphasis was followed by substantial research worldwide on the diagnosis and treatment of BMEC.…”

Section: Characteristics Of Patients With Bmec In Different Countriesmentioning

confidence: 99%

“…However, one issue arose from those studies: the repeated submission of case reports by diligent Japanese doctors resulted in a large number of repeated cases being reported. Ogawa and colleagues [19] [18] , the United States [20] , and Japan [19] is shown in Table 1; 31 Chinese patients were diagnosed and treated at our hospital. We have also included published reports from the MD Anderson Cancer Center in the United States in this review.…”

Section: Characteristics Of Patients With Bmec In Different Countriesmentioning

confidence: 99%

“…BM typically occurs after treatment [4,6,7,18,[20][21][22][23] , although concurrent BM and EC have been rarely reported (less than 10 cases in the literature). In some individual case reports [7,[24][25][26] , especially in misdiagnosed cases [7,25,26] , BM was found before the primary lesion of the esophagus was detected.…”

Section: Misdiagnosis Of Bmec That Occurs Earlier Than the Diagnosis mentioning

confidence: 99%

“…In those cases, BM was often misdiagnosed as meningitis, a pituitary tumor, or glioma. BM predominantly occurs after treatment [4,6,7,18,[20][21][22][23] based on the results of BM occurrence at 5 [27] , 6.7 [17] , 8.4 [28] , or 10 mo [29] after treatment, ranging from 4 to 57 mo. Clinical staging and adjuvant therapy are considered to be associated with BMEC, but the factors influencing the interval from treatment to BMEC occurrence have not been clarified.…”

Section: Misdiagnosis Of Bmec That Occurs Earlier Than the Diagnosis mentioning

confidence: 99%

“…In their study, they included 403 patients with esophageal cancer who received only Clinical characteristic Japan [19] United States [20] China [18] n = 36 n = 27 n = 31 [23] , 518 esophageal adenocarcinoma patients receiving trimodal therapy were retrospectively analyzed. In that study, distant metastasis was found in 188 cases (36.3%), including 20 cases of BM (3.9%).…”

Section: Auxiliary Treatment Of Esophageal Cancer Promotes Bmecmentioning

confidence: 99%

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Incidence and treatment of brain metastasis in patients with esophageal carcinoma

Feng¹,

Zhang²,

Zheng³

et al. 2015

WJG

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Brain metastasis from esophageal carcinoma (BMEC) is very rare, but its incidence has increased in the United States, Japan, China and other counties. Reports on BMEC have largely been focused on examining whether adjuvant therapy for esophageal cancer influences the survival duration of BMEC patients and on the imaging characteristics of BMEC determined using new medical equipment. The difference between different pathological types of esophageal cancer, especially adenocarcinoma and squamous cell carcinoma, is one important factor used to assess the influence of BMEC. Adjuvant therapy, including radiotherapy and chemotherapy, for esophageal cancer with different characteristics in different countries may affect BMEC treatment outcomes. The degree of popularization of advanced medical equipment is a major concern related to the prevalence of BMEC. Furthermore, targeted BMEC treatment is under development in developed countries. In this article, we reviewed the debate surrounding BMEC and analyzed BMEC studies from different perspectives.

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Section: Characteristics Of Patients With Bmec In Different Countriesmentioning

confidence: 99%

Section: Characteristics Of Patients With Bmec In Different Countriesmentioning

confidence: 99%

Section: Misdiagnosis Of Bmec That Occurs Earlier Than the Diagnosis mentioning

confidence: 99%

Section: Misdiagnosis Of Bmec That Occurs Earlier Than the Diagnosis mentioning

confidence: 99%

Section: Auxiliary Treatment Of Esophageal Cancer Promotes Bmecmentioning

confidence: 99%

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Incidence and treatment of brain metastasis in patients with esophageal carcinoma

Feng¹,

Zhang²,

Zheng³

et al. 2015

WJG

Self Cite

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Clinical outcome and molecular characterization of brain metastases from esophageal and gastric cancer: a systematic review

et al. 2017

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The aim of the study was to collect the available data on central nervous system (CNS) metastases from esophageal and gastric cancer. A PubMed, EMBASE, SCOPUS, Web of Science, LILACS, Ovid and Cochrane Library search was performed. Thirty-seven studies including 779 patients were considered. Among the data extracted, treatment of tumor and brain metastases (BMs), time to BMs development, number and subsite, extracerebral metastases rate, median overall survival (OS) and prognostic factors were included. For esophageal cancer, the median OS from diagnosis of BMs was 4.2 months. Prognostic factors for OS included: performance status, multimodal therapy, adjuvant chemotherapy, single BM, brain only disease and surgery. For gastric cancer, median OS was 2.4 months. Prognostic factors for OS included: recursive partitioning analysis class 2, stereotactic radiosurgery (SRT) and use of intrathecal therapy. HER2-positive gastric cancer was shown to be associated with a higher risk and shorter time to CNS relapse. Patients harboring BMs from gastric and esophageal tumors, except cases with single lesions that are treated aggressively, have a poor prognosis. SRT (plus or minus surgery and whole brain radiotherapy) seems to give better results in terms of longer OS after brain relapse.

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Brain metastases: neuroimaging

Pope

2018

Handbook of Clinical Neurology

154

130

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Magnetic resonance imaging (MRI) is the cornerstone for evaluating patients with brain masses such as primary and metastatic tumors. Important challenges in effectively detecting and diagnosing brain metastases and in accurately characterizing their subsequent response to treatment remain. These difficulties include discriminating metastases from potential mimics such as primary brain tumors and infection, detecting small metastases, and differentiating treatment response from tumor recurrence and progression. Optimal patient management could be benefited by improved and well-validated prognostic and predictive imaging markers, as well as early response markers to identify successful treatment prior to changes in tumor size. To address these fundamental needs, newer MRI techniques including diffusion and perfusion imaging, MR spectroscopy, and positron emission tomography (PET) tracers beyond traditionally used 18-fluorodeoxyglucose are the subject of extensive ongoing investigations, with several promising avenues of added value already identified. These newer techniques provide a wealth of physiologic and metabolic information that may supplement standard MR evaluation, by providing the ability to monitor and characterize cellularity, angiogenesis, perfusion, pH, hypoxia, metabolite concentrations, and other critical features of malignancy. This chapter reviews standard and advanced imaging of brain metastases provided by computed tomography, MRI, and amino acid PET, focusing on potential biomarkers that can serve as problem-solving tools in the clinical management of patients with brain metastases.

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Neuroimaging and clinical characteristics of brain metastases from esophageal carcinoma in Chinese patients

Cited by 10 publications

References 26 publications

Incidence and treatment of brain metastasis in patients with esophageal carcinoma

Incidence and treatment of brain metastasis in patients with esophageal carcinoma

Clinical outcome and molecular characterization of brain metastases from esophageal and gastric cancer: a systematic review

Brain metastases: neuroimaging

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