Neuroimaging and cognitive functions in temporal lobe epilepsy: A review of the literature

Allone, Cettina; Buono, Viviana Lo; Corallo, Francesco; Pisani, Laura Rosa; Pollicino, Patrizia; Bramantı, Placido; Marıno, Silvia

doi:10.1016/j.jns.2017.08.007

Cited by 121 publications

(85 citation statements)

References 58 publications

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“…Those cognitive alterations in TLE patients have been grouped in three distinct types of cognitive profiles: (a) mild deficits (47% of patients; for a review see (Höller & Trinka, ), (b) memory deficits (24%) and (c) memory and executive functions deficits (29%) (cf. the recent review of Allone et al, ). These three profiles provide different results, depending on the type of epilepsy and cognitive evolution (Hermann, Seidenberg, Lee, Chan, & Rutecki, ).…”

Section: How Is Tl‐dependent Cognition Altered In Temporal Lobe Epilementioning

confidence: 96%

“…Cognitive deficits are frequent in TLE patients (Helmstaedter & Kockelmann, ). Related to extensive structural abnormalities beyond the HPC connectome, TLE patients present a panel of various cognitive alterations, from memory impairments to executive functions, language, intellectual quotient, object verbal naming and sensorimotor skills (Hermann, Seidenberg, Schoenfeld, & Davies, ; Oyegbile et al, ; Riley et al, ; Robertson, Evans, Walterfang, Ng, & Velakoulis, ); for review see (Bell, Lin, Seidenberg, & Hermann, ) and (Allone et al, ). Those cognitive alterations in TLE patients have been grouped in three distinct types of cognitive profiles: (a) mild deficits (47% of patients; for a review see (Höller & Trinka, ), (b) memory deficits (24%) and (c) memory and executive functions deficits (29%) (cf.…”

Section: How Is Tl‐dependent Cognition Altered In Temporal Lobe Epilementioning

confidence: 99%

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Update on temporal lobe‐dependent information processing, in health and disease

Chauvière

2019

Eur J of Neuroscience

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The past decade has been characterized by a lot of remodeling in the field of learning and memory. Both of them, often associated with neuronal oscillations, an emergent property of brain networks, are governed by temporal lobe (TL) functional connectivity. An impairment of oscillatory mechanisms indeed often leads to TL‐dependent cognitive deficits. While the classical view assigned the TL a major role in spatial information processing, new theories rather confer to the TL a more general function in cognitive processes beyond space representation. The present review covers, both in humans and in animal models, (a) the updated role of the TL in cognitive processes, addressing current debates in the field and proposing a scenario on how TL structures cooperate in order to bind an integrated representation of afferent information, (b) the oscillatory mechanisms underlying these TL‐dependent cognitive functions (theta, gamma, sharp wave ripples) and (c) how TL‐dependent cognition is altered during temporal lobe epilepsy, proposing a scenario on how reorganized TL networks in TLE leads to rhythmopathies and cognitive deficits. Temporal lobe epilepsy (TLE) is a well‐studied neurological disease. Patients do not only suffer from epileptic seizures but also from cognitive and behavioral deficits between their seizures called comorbidities. TLE animal models are therefore used to understand how and when these comorbidities arise and what their underlying mechanisms are.

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Section: How Is Tl‐dependent Cognition Altered In Temporal Lobe Epilementioning

confidence: 96%

Section: How Is Tl‐dependent Cognition Altered In Temporal Lobe Epilementioning

confidence: 99%

Update on temporal lobe‐dependent information processing, in health and disease

Chauvière

2019

Eur J of Neuroscience

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“…MRI, fluorodeoxyglucose, positron emission tomography (PET), functional MRI, single-photon emission computed tomography (SPECT), subtraction ictal SPECT co-registered to MRI (SIS-COM), and magnetoencephalography can all be used to help with localization and to identify any anatomic anomalies that would account for seizures. 24,25 It is of the utmost importance to separate patients with more than one seizure focus (such as bitemporal independent foci) from those with a unilateral temporal lobe origin. Wada testing can be used to aid in identification of hemispheric memory and language function, although functional MRI is used more frequently now given its noninvasive approach.…”

Section: Preoperative Evaluationmentioning

confidence: 99%

Surgical Treatments of Epilepsy

2020

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Nearly 30% of epilepsy patients are refractory to medical therapy. Surgical management of epilepsy is an increasingly viable option for these patients. Although surgery has historically been used as a palliative option, improvements in technology and outcomes show its potential in certain subsets of patients. This article reviews the two main categories of surgical epilepsy treatment—resective surgery and neuromodulation. Resective surgery includes temporal lobe resections, extratemporal resections, laser interstitial thermal therapy, and disconnection procedures. We discuss the three main types of neuromodulation—vagal nerve stimulation, responsive neurostimulation, and deep brain stimulation for epilepsy. The history and indications are explored for each type of treatment. Given the myriad types of resection and neuromodulation techniques, patient selection is reviewed in detail, with a discussion on which patients are most likely to benefit from different treatment strategies. We also discuss outcomes with examples of the pertinent landmark trials and their results. Finally, complications and surgical technique are reviewed. As new indications emerge and patient selection is refined, surgical management will continue to evolve as an adjuvant therapy for epileptic patients.

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“…Epilepsy is a chronic neurological disorder, and it has a prevalence of 5 to 10 cases per 1000 people. The causes of epilepsy may be genetic or acquired, such as brain tumors or strokes [ 9 ]. Previous studies reported that abnormalities in cognition, behavior/psychiatric status, and psychosocial functioning in relation to patients with epilepsy show cognitive and behavioral disturbances, especially in terms of memory, attention, and mental processing speed.…”

Section: Introductionmentioning

confidence: 99%

Application of the P300 Event-Related Potential in the Diagnosis of Epilepsy Disorder: A Review

et al. 2018

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Epilepsy is one of the most serious chronical neurological disorders, affecting more than 50 million people worldwide. It can be defined as a spectrum disorder, and patients with epilepsy possess abnormalities in cognitive functions. A number of factors can cause cognitive dysfunctions in epileptic syndromes, including etiology, the age of onset, type of seizure and severity, duration, and antiepileptic drugs. Event-related potentials (ERPs) are very useful clinical and research instruments to evaluate cognitive function in patients with neuropsychiatry disorders. Event-related potentials directly reflect cortical neuronal activity and provide a particular level of temporal resolution. Among various ERP components, the P300 is the most important component for assessing cognitive processes such as attention, working memory, and concentration. Numerous studies have reported the abnormalities in amplitude or latency of P300 component of ERP in epileptic patients, and these abnormalities are indicative of cognitive dysfunction. Therefore, the purpose of this review is to consolidate the existing literature in connection with the use of P300 in epileptic patients.

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Neuroimaging and cognitive functions in temporal lobe epilepsy: A review of the literature

Cited by 121 publications

References 58 publications

Update on temporal lobe‐dependent information processing, in health and disease

Update on temporal lobe‐dependent information processing, in health and disease

Surgical Treatments of Epilepsy

Application of the P300 Event-Related Potential in the Diagnosis of Epilepsy Disorder: A Review

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