Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature

Esagoff, Aaron I.; Stevens, Daniel A.; Kosyakova, Natalia; Woodard, Kaylee F.; Jung, Diane; Richey, Lisa N.; Luna, Licia P.; Bray, Michael J.C.; Bryant, Barry R.; Rodriguez, Carla; Krieg, Akshay; Trapp, Nicholas T.; Jones, Melissa B.; Roper, Carrie; Goldwaser, Eric L.; Berich-Anastasio, Emily; Pletnikova, Alexandra; Lobner, Katie; Lauterbach, Margo D.; Sair, Haris I.; Peters, Matthew E.

doi:10.1089/neu.2021.0453

Cited by 6 publications

(6 citation statements)

References 73 publications

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“…A.I. Esagoff et al [22] did not conduct a targeted neuropsychological study of cognitive functioning and its impact on the effectiveness of treatment, unlike the present study. N.L.…”

Section: Resultsmentioning

confidence: 74%

“…S.M. Lippa et al [4], studying PTSD symptoms associated with cognitive function after TBI, found that the [21] demonstrated neuroimaging indicators of the combined effect of TBI and PTSD on the white matter of the brain in the form of a larger number of spatially heterogeneous areas of abnormally low fractional anisotropy, or "potholes", which was found in veterans with a history of mild TBI and was not associated with age, time after injury, PTSD, mood disorders or alcohol use with harmful effects [20][21][22]. However, A.R.…”

Section: Resultsmentioning

confidence: 99%

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Influence of cognitive functioning on the effectiveness of treatment of veterans with post-traumatic stress disorder and mild traumatic brain injury

Smashna

2023

ijmmr

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A history of traumatic brain injury in veterans is associated with higher use of mental health services, regardless of psychiatric diagnoses, which makes it important to develop a comprehensive approach to treatment and evaluate its effectiveness. The study aimed to investigate the impact of cognitive functioning among 329 veterans with comorbid post-traumatic stress disorder and mild traumatic brain injury on the effectiveness of combination therapy. The following tests were used to assess cognitive functioning: the Ray-Osterritz test, the Symbolic Communication Test, the Stroop test, and the Verbal Fluency Test. Functioning was assessed using the World Health Organization Questionnaire for the Assessment of Disability. The effectiveness of the combination therapy was also assessed using the Four-Dimensional Symptom Inventory. The influence of cognitive functioning on the effectiveness of 8-week complex therapy for veterans with this comorbidity was confirmed. The results of the Trail Making Test had statistically significant negative correlations with the cognitive sphere scale (ρ = -0.237; p = 0.0117) and the integral index of the World Health Organization questionnaire for the assessment of disability (ρ= -0.192; p = 0.0424), as well as positive correlations with the scales of self-care (ρ = 0.2038; p = 0.0311) and daily activity (ρ = 0.2048; p = 0.0303). It was found that patients with post-traumatic stress disorder, mild traumatic brain injury and their comorbidity responded differently to therapy, which was determined by the clinical features of their cognitive processes, namely associative performance, control rigidity/flexibility, attention, working memory and executive function. The dynamics of cognitive functioning differed in each group. It was also found that cognitive symptoms were targeted by therapy, as evidenced by their reduction after the intervention. The data obtained will allow for a more efficient and comprehensive organization of specialised psychiatric care for veterans, and cognitive functioning is predictive of the effectiveness and duration of treatment

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“…A.I. Esagoff et al [22] did not conduct a targeted neuropsychological study of cognitive functioning and its impact on the effectiveness of treatment, unlike the present study. N.L.…”

Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Influence of cognitive functioning on the effectiveness of treatment of veterans with post-traumatic stress disorder and mild traumatic brain injury

Smashna

2023

ijmmr

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“…Since this initial study, more than 100 rsfMRI studies have been published in TBI patients with a particular surge in contributions in the most recent years. The scope, methodology, and utility of rsfMRI in TBI has been reviewed in previous review papers (e.g., Caeyenberghs et al, 2017 , Hayes et al, 2016 , Morelli et al, 2021 , O’Neill et al, 2017 , Esagoff et al, 2023 ). For example, Hayes and colleagues (2016) summarized findings from both structural, diffusion, and rsfMRI studies to examine how brain networks are disrupted by axonal injury.…”

Section: Introductionmentioning

confidence: 99%

ENIGMA’s simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury

Caeyenberghs,

Imms,

Irimia

et al. 2024

NeuroImage: Clinical

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“…A large body of evidence now confirms a tendency of PTSD occurrence after TBI [ 15 , 16 , 17 ]. In fact, some studies suggest that post-TBI PTSD is as common a psychiatric complication as post-TBI depression [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Post-Traumatic Stress Disorder Due to Brain Injury and Glutamate Intake: A Systematic Review

Gruenbaum,

Zlotnik,

Oleshko

et al. 2024

Nutrients

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There is a growing body of evidence that suggests a connection between traumatic brain injury (TBI) and subsequent post-traumatic stress disorder (PTSD). While the exact mechanism is unknown, we hypothesize that chronic glutamate neurotoxicity may play a role. The consumption of dietary glutamate is a modifiable factor influencing glutamate levels in the blood and, therefore, in the brain. In this systematic review, we explored the relationship between dietary glutamate and the development of post-TBI PTSD. Of the 1748 articles identified, 44 met the inclusion criteria for analysis in this review. We observed that individuals from countries with diets traditionally high in glutamate had greater odds of developing PTSD after TBI (odds ratio = 15.2, 95% confidence interval 11.69 to 19.76, p < 0.01). These findings may support the hypothesis that chronically elevated blood glutamate concentrations caused by high dietary intake invoke neurodegeneration processes that could ultimately result in PTSD. Further studies will clarify whether lowering glutamate via diet would be an effective strategy in preventing or treating post-TBI PTSD.

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Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature

Cited by 6 publications

References 73 publications

Influence of cognitive functioning on the effectiveness of treatment of veterans with post-traumatic stress disorder and mild traumatic brain injury

Influence of cognitive functioning on the effectiveness of treatment of veterans with post-traumatic stress disorder and mild traumatic brain injury

ENIGMA’s simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury

The Relationship between Post-Traumatic Stress Disorder Due to Brain Injury and Glutamate Intake: A Systematic Review

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